Search Results - "Gutman, Orit"

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression by Lu, Yi, Wu, Tiantian, Gutman, Orit, Lu, Huasong, Zhou, Qiang, Henis, Yoav I., Luo, Kunxin

“…TAZ promotes growth, development and tumorigenesis by regulating the expression of target genes. However, the manner in which TAZ orchestrates the…”
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Formation of self-organizing functionally distinct Rho of plants domains involves a reduced mobile population by Sternberg, Hasana, Buriakovsky, Ella, Bloch, Daria, Gutman, Orit, Henis, Yoav I, Yalovsky, Shaul

“…Rho family proteins are central to the regulation of cell polarity in eukaryotes. Rho of Plants-Guanyl nucleotide Exchange Factor (ROPGEF) can form…”
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Src-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites by Gottlieb-Abraham, Efrat, Shvartsman, Dmitry E, Donaldson, John C, Ehrlich, Marcelo, Gutman, Orit, Martin, G Steven, Henis, Yoav I

“…Src interactions with the plasma membrane are an important determinant of its activity. In turn, Src activity modulates its association with the membrane…”
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Rac-mediated Stimulation of Phospholipase Cγ2 Amplifies B Cell Receptor-induced Calcium Signaling by Walliser, Claudia, Tron, Kyrylo, Clauss, Karen, Gutman, Orit, Kobitski, Andrei Yu, Retlich, Michael, Schade, Anja, Röcker, Carlheinz, Henis, Yoav I., Nienhaus, G. Ulrich, Gierschik, Peter

“…The Rho GTPase Rac is crucially involved in controlling multiple B cell functions, including those regulated by the B cell receptor (BCR) through increased…”
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Rac2 Regulation of Phospholipase C-β2 Activity and Mode of Membrane Interactions in Intact Cells by Illenberger, Daria, Walliser, Claudia, Strobel, Joachim, Gutman, Orit, Niv, Hagit, Gaidzik, Verena, Kloog, Yoel, Gierschik, Peter, Henis, Yoav I.

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Complex Formation Among TGF-β Receptors in Live Cell Membranes Measured by Patch-FRAP by Szilágyi, Szabina Szófia, Gutman, Orit, Henis, Yoav I

“…Signaling by receptors from the transforming growth factor-β (TGF-β) superfamily plays critical roles in multiple physiological and pathological processes…”
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Oligomeric interactions of TGF-β and BMP receptors by Ehrlich, Marcelo, Gutman, Orit, Knaus, Petra, Henis, Yoav I.

“…Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) cytokines participate in a multiplicity of ways in the regulation of numerous…”
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Abstract IA27: Regulation of Hippo and TAZ signaling in breast cancer by Lu, Yi, Wu, Tiantian, Zhu, Qingwei, Gutman, Orit, Henis, Yoav, Luo, Kunxin

“…Abstract TAZ and YAP are transcriptional coactivators that can contribute to cancer by promoting proliferation, tumorigenesis, and cancer stem cell expansion…”
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Noncatalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells by Wist, Martin, Meier, Laura, Gutman, Orit, Haas, Jennifer, Endres, Sascha, Zhou, Yuan, Rösler, Reinhild, Wiese, Sebastian, Stilgenbauer, Stephan, Hobeika, Elias, Henis, Yoav I., Gierschik, Peter, Walliser, Claudia

“…Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or…”
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The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions by Gottlieb-Abraham, Efrat, Gutman, Orit, Pai, Govind M, Rubio, Ignacio, Henis, Yoav I

“…The interactions of Src family kinases (SFKs) with the plasma membrane are crucial for their activity. They depend on their fatty-acylated N-termini,…”
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Membrane Interactions of a Constitutively Active GFP-Ki-Ras 4B and Their Role in Signaling by Niv, Hagit, Gutman, Orit, Henis, Yoav I., Kloog, Yoel

“…Membrane anchorage of Ras proteins in the inner leaflet of the plasma membrane is an important factor in their signaling and oncogenic potential. Despite these…”
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Differential Effects of Prenylation and S-Acylation on Type I and II ROPS Membrane Interaction and Function by Sorek, Nadav, Gutman, Orit, Bar, Einat, Abu-Abied, Mohamad, Feng, Xuehui, Running, Mark P., Lewinsohn, Efraim, Ori, Naomi, Sadot, Einat, Henis, Yoav I., Yalovsky, Shaul

“…Prenylation primarily by geranylgeranylation is required for membrane attachment and function of type I Rho of Plants (ROPs) and Gy proteins, while type II…”
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An S-Acylation Switch of Conserved G Domain Cysteines Is Required for Polarity Signaling by ROP GTPases by Sorek, Nadav, Segev, Oshik, Gutman, Orit, Bar, Einat, Richter, Sandra, Poraty, Limor, Hirsch, Joel A., Henis, Yoav I., Lewinsohn, Efraim, Jürgens, Gerd, Yalovsky, Shaul

“…Rho GTPases are master regulators of cell polarity [ 1]. For their function, Rhos must associate with discrete plasma membrane domains [ 2]. Rho of Plants…”
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Activated K-Ras and H-Ras Display Different Interactions with Saturable Nonraft Sites at the Surface of Live Cells by Niv, Hagit, Gutman, Orit, Kloog, Yoel, Henis, Yoav I.

“…Ras-membrane interactions play important roles in signaling and oncogenesis. H-Ras and K-Ras have nonidentical membrane anchoring moieties that can direct them…”
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Cyclodextrins but not Compactin Inhibit the Lateral Diffusion of Membrane Proteins Independent of Cholesterol by Shvartsman, Dmitry E., Gutman, Orit, Tietz, Aliza, Henis, Yoav I.

“…Cholesterol and glycosphingolipid‐enriched membrane domains, termed lipid rafts, were proposed to play important roles in trafficking and signaling events…”
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Dynamic or Stable Interactions of Influenza Hemagglutinin Mutants with Coated Pits by Fire, Ella, Gutman, Orit, Roth, Michael G., Henis, Yoav I.

“…Measurements of the lateral mobility of native and mutated membrane proteins, combined with treatments that alter clathrin lattice structure, are capable of…”
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An S-Acylation Switch of Conserved G Domain Cysteines Is Required for Polarity Signaling by ROP GTPases by Sorek, Nadav, Segev, Oshik, Gutman, Orit, Bar, Einat, Richter, Sandra, Poraty, Limor, Hirsch, Joel A., Henis, Yoav I., Lewinsohn, Efraim, Jürgens, Gerd, Yalovsky, Shaul

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Noncatalytic Bruton's tyrosine kinase activates PLCγ 2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells by Wist, Martin, Meier, Laura, Gutman, Orit, Haas, Jennifer, Endres, Sascha, Zhou, Yuan, Rösler, Reinhild, Wiese, Sebastian, Stilgenbauer, Stephan, Hobeika, Elias, Henis, Yoav I, Gierschik, Peter, Walliser, Claudia

“…Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or…”
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Noncatalytic Bruton's tyrosine kinase activates PLCγ 2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells by Wist, Martin, Meier, Laura, Gutman, Orit, Haas, Jennifer, Endres, Sascha, Zhou, Yuan, Rösler, Reinhild, Wiese, Sebastian, Stilgenbauer, Stephan, Hobeika, Elias, Henis, Yoav I, Gierschik, Peter, Walliser, Claudia

“…Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or…”
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Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets by Shvartsman, Dmitry E, Donaldson, John C, Diaz, Begoña, Gutman, Orit, Martin, G. Steven, Henis, Yoav I

“…Src functions depend on its association with the plasma membrane and with specific membrane-associated assemblies. Many aspects of these interactions are…”
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