Sex-Related Differences in Life Expectancy Compared to General Population after Surgery for Ascending Aortic Aneurysm

Sex-Related Differences in Life Expectancy Compared to General Population after Surgery for Ascending Aortic Aneurysm

: Understanding sex-based differences in cardiovascular outcomes is paramount to improving clinical outcomes. Surgery is an aggressive but effective therapy for ascending aortic aneurysm. We sought to determine if being a woman is a risk factor for long-term mortality after this surgery. We compared...

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Published in:Journal of clinical medicine Vol. 13; no. 15; p. 4554
Main Authors: Almendárez, Marcel, Formica, Francesco, Gutierrez Sáenz de Santamaría, Jorge, Avanzas, Pablo, Escalera, Alain, Alvarez-Velasco, Rut, Pascual, Isaac, Silva, Jacobo, Díaz, Rocío, Alperi, Alberto, Hernández-Vaquero, Daniel
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 04-08-2024
Subjects:
Age
Aortic aneurysms
Cardiovascular disease
Chronic obstructive pulmonary disease
Coronary vessels
Demographic aspects
Diagnosis
Females
Gender differences
Life expectancy
Males
Mortality
Postoperative period
Prognosis
Surgery
Women
Spain
relative survival
ascending aortic aneurysm
aortic aneurysm surgery
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Summary:: Understanding sex-based differences in cardiovascular outcomes is paramount to improving clinical outcomes. Surgery is an aggressive but effective therapy for ascending aortic aneurysm. We sought to determine if being a woman is a risk factor for long-term mortality after this surgery. We compared their life expectancy with a general population of the same age, sex, year, and region. : We compared men and women undergoing AAA surgery at our institution from 2000 to 2019. After balancing the population with propensity score (PS) matching, we compared long-term mortality control with a Cox regression. We determined the RS using the Ederer II method and compared it to a healthy reference population of the same age, sex, and region. : From 2000 to 2019, 232 women and 506 men underwent ascending aortic aneurysm surgery. After a mean follow-up of 51.5 ± 34.5 months, sex was not an independent risk factor for long-term mortality in the multivariable analysis [HR: 0.68 (95% CI 0.43-1.07, = 0.23)]. Matching by baseline characteristics, 196 pairs were analyzed with no differences regarding mortality in the Cox regression [HR: 1.11 (95% CI 0.65-1.9, = 0.23)]. Men and women who survived the postoperative period presented a relative survival of 100.3% (95% CI 97.4-101%) and 100.3% (95% CI 98.9-101.1%), respectively, similar to the reference population without the disease. : For patients undergoing AAA surgery, sex was not an independent predictor of mortality. Men and women who survived the postoperative period presented a similar life expectancy to that of the reference population (people free from the disease of the same age, sex, year, and region).
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13154554