Search Results - "Gutierrez‐Valencia, Alicia"
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Stepped-Dose Versus Full-Dose Efavirenz for HIV Infection and Neuropsychiatric Adverse Events: A Randomized Trial
Published in Annals of internal medicine (04-08-2009)“…More than 50% of patients who start efavirenz treatment develop limiting neuropsychiatric adverse events (NPAEs). To assess whether stepwise dosing of…”
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Darunavir/cobicistat showing similar effectiveness as darunavir/ritonavir monotherapy despite lower trough concentrations
Published in Journal of the International AIDS Society (01-02-2018)“…Introduction When darunavir (DRV) 800 mg is boosted with 150 mg cobicistat (DRVcobi), DRV trough concentration (Ctrough) is about 30% lower as compared to…”
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Intracellular and plasma pharmacokinetics of 400 mg of etravirine once daily versus 200 mg of etravirine twice daily in HIV-infected patients
Published in Journal of antimicrobial chemotherapy (01-03-2012)“…Objectives To compare intracellular and plasma etravirine concentrations when etravirine was given at 200 mg/12 h versus 400 mg/24 h and to evaluate whether…”
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Response to: Reply to: Anti-CD4 autoantibodies in immunological nonresponder people living with HIV: cause of CD4+ T cell depletion?
Published in AIDS (London) (01-03-2023)Get full text
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Association between Vancomycin Pharmacokinetic Parameters and Clinical and Microbiological Efficacy in a Cohort of Neonatal Patients
Published in Antimicrobial agents and chemotherapy (15-11-2022)“…Vancomycin pharmacokinetic/pharmacodynamic (PK/PD) targets have not been validated in the neonatal population as no specifically designed studies are…”
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Eradication of Hepatitis C Virus (HCV) Reduces Immune Activation, Microbial Translocation, and the HIV DNA Level in HIV/HCV-Coinfected Patients
Published in The Journal of infectious diseases (13-07-2018)“…There are contradictory data about the influence that hepatitis C virus (HCV) has on immune activation and inflammation in patients coinfected with human…”
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Immunological and inflammatory changes after simplifying to dual therapy in virologically suppressed HIV-infected patients through week 96 in a randomized trial
Published in Clinical microbiology and infection (01-08-2022)“…To evaluate whether simplification of antiretroviral treatment to dual therapy (DT) negatively impacts immune recovery (IR), immune activation and inflammation…”
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Anti-CD4 autoantibodies in immunological nonresponder people with HIV: cause of CD4 + T-cell depletion?
Published in AIDS (London) (15-07-2022)“…We aimed to evaluate the anti-CD4 IgG role in the poor immune recovery of immunological nonresponder people with HIV (INR). INR display low CD4 + T-cell…”
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Stability of temocillin in outpatient parenteral antimicrobial therapy: is it a real option?
Published in Journal of antimicrobial chemotherapy (03-10-2023)“…Abstract Background Temocillin is an interesting alternative to carbapenems for susceptible Enterobacteriaceae. Although its use in outpatient parenteral…”
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Is Once-Daily High-Dose Ceftriaxone plus Ampicillin an Alternative for Enterococcus faecalis Infective Endocarditis in Outpatient Parenteral Antibiotic Therapy Programs?
Published in Antimicrobial agents and chemotherapy (16-12-2020)“…Ceftriaxone administered as once-daily high-dose short infusion combined with ampicillin has been proposed for the treatment of infective endocarditis in…”
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Response to a reinforced hepatitis B vaccination scheme in HIV-infected patients under real-life conditions
Published in Vaccine (06-05-2019)“…•HIV infected patients are at high risk of hepatitis B virus infection.•Response to standard hepatitis B virus vaccine is suboptimal low in…”
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Is immune recovery different depending on the use of integrase strand transfer inhibitor-, non-nucleoside reverse transcriptase- or boosted protease inhibitor-based regimens in antiretroviral-naive HIV-infected patients?
Published in Journal of antimicrobial chemotherapy (01-01-2020)“…Abstract Objectives To analyse whether integrase inhibitor (InSTI)-based regimens achieve better immunological recovery than NNRTI- or boosted PI (bPI)-based…”
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HIV-1-specific T-cell responses and exhaustion profiles in people with HIV after switching to dual therapy vs. maintaining triple therapy based on integrase inhibitors
Published in Biomedicine & pharmacotherapy (01-12-2023)“…Dual therapy (DT) has shown comparable results to triple therapy (TT) in efficacy and other immunological aspects. However, there are still some concerns about…”
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SARS-CoV-2 infection in a pediatrics STAT1 GOF patient under Ruxolitinib therapy-a matter of balance?
Published in Journal of clinical immunology (01-10-2021)Get full text
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Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes
Published in Frontiers in immunology (14-09-2022)“…Coronavirus-19 (COVID-19) disease is driven by an unchecked immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus which…”
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Long-term effects on immunological, inflammatory markers, and HIV-1 reservoir after switching to a two-drug versus maintaining a three-drug regimen based on integrase inhibitors
Published in Frontiers in immunology (11-07-2024)“…To compare the long-term effects on immune parameters, inflammation, and HIV-1 reservoir after switching to a two-drug (2DR) versus maintaining an integrase…”
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Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients
Published in PloS one (14-07-2022)“…Background The SARS-CoV-2 pandemic has overwhelmed hospital services due to the rapid transmission of the virus and its severity in a high percentage of cases…”
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Rapid virological response at week 4 predicts response to pegylated interferon plus ribavirin among HIV/HCV-coinfected patients
Published in Antiviral therapy (01-01-2007)“…The clinical applicability of early viral kinetics at week 4 in predicting sustained virological response (SVR) of pegylated interferon (peg-IFN) plus…”
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Absolute CD4+ T cell count overstate immune recovery assessed by CD4+/CD8+ ratio in HIV-infected patients on treatment
Published in PloS one (22-10-2018)“…To analyse the correlation and concordance between aCD4, CD4%, CD4/CD8, their intra-patient variability, and to compare the immune recovery (IR) rates based on…”
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Long-term effectiveness, safety, and tolerability of doravirine in antiretroviral-experienced people with HIV in real life
Published in Microbiology spectrum (06-08-2024)“…Real-life data on doravirine (DOR) in different drug combinations are limited. We evaluated the effectiveness of DOR plus two nucleos(t)ide reverse…”
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