Search Results - "Gutierrez‐Aranda, Ivan"

Human Induced Pluripotent Stem Cells Develop Teratoma More Efficiently and Faster Than Human Embryonic Stem Cells Regardless the Site of Injection by Gutierrez‐Aranda, Ivan, Ramos‐Mejia, Veronica, Bueno, Clara, Munoz‐Lopez, Martin, Real, Pedro. J., Mácia, Angela, Sanchez, Laura, Ligero, Gertrudis, Garcia‐Parez, Jose L., Menendez, Pablo

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The Nodal inhibitor Lefty is negatively modulated by the microRNA miR‐302 in human embryonic stem cells by Barroso-delJesus, Alicia, Lucena-Aguilar, Gema, Sanchez, Laura, Ligero, Gertrudis, Gutierrez-Aranda, Ivan, Menendez, Pablo

“…ABSTRACT MicroRNAs (miRNAs) have been shown to be important in early development and maintenance of human embryonic stem cells (hESCs). The miRNA miR‐302–367…”
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Enrichment of Human ESC‐Derived Multipotent Mesenchymal Stem Cells with Immunosuppressive and Anti‐Inflammatory Properties Capable to Protect Against Experimental Inflammatory Bowel Disease by Sánchez, Laura, Gutierrez‐Aranda, Iván, Ligero, Gertrudis, Rubio, Ruth, Muñoz‐López, Martín, García‐Pérez, José L., Ramos, Verónica, Real, Pedro. J., Bueno, Clara, Rodríguez, René, Delgado, Mario, Menendez, Pablo

“…Human ESCs provide access to the earliest stages of human development and may serve as an unlimited source of functional cells for future cell therapies. The…”
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FUS‐CHOP Fusion Protein Expression Coupled to p53 Deficiency Induces Liposarcoma in Mouse but Not in Human Adipose‐Derived Mesenchymal Stem/Stromal Cells by Rodriguez, Rene, Rubio, Ruth, Gutierrez‐Aranda, Ivan, Melen, Gustavo J., Elosua, Carolina, García‐Castro, Javier, Menendez, Pablo

“…Human sarcomas have been modeled in mice by expression of specific fusion genes in mesenchymal stem cells (MSCs). However, sarcoma models based on human MSCs…”
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Nodal/Activin Signaling Predicts Human Pluripotent Stem Cell Lines Prone to Differentiate Toward the Hematopoietic Lineage by Ramos-Mejia, Veronica, Melen, Gustavo J, Sanchez, Laura, Gutierrez-Aranda, Ivan, Ligero, Gertrudis, Cortes, Jose L, Real, Pedro J, Bueno, Clara, Menendez, Pablo

“…Lineage-specific differentiation potential varies among different human pluripotent stem cell (hPSC) lines, becoming therefore highly desirable to…”
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Maintenance of human embryonic stem cells in media conditioned by human mesenchymal stem cells obviates the requirement of exogenous basic fibroblast growth factor supplementation by Sánchez, Laura, Gutierrez-Aranda, Iván, Ligero, Gertrudis, Martín, Miguel, Ayllón, Verónica, Real, Pedro J, Ramos-Mejía, Verónica, Bueno, Clara, Menendez, Pablo

“…Despite the improvements in the human embryonic stem cell (hESC) culture systems, very similar conditions to those used to maintain hESCs on mouse feeders are…”
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Deficiency in p53 but not Retinoblastoma Induces the Transformation of Mesenchymal Stem Cells In vitro and Initiates Leiomyosarcoma In vivo by RUBIO, Ruth, GARCIA-CASTRO, Javier, GUTIERREZ-ARANDA, Iván, PARAMIO, Jesús, SANTOS, Mirentxu, CATALINA, Purificación, LEONE, Paola E, MENENDEZ, Pablo, RODRIGUEZ, René

“…Sarcomas have been modeled in mice by the expression of specific fusion genes in mesenchymal stem cells (MSC), supporting the concept that MSCs might be the…”
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A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification by Bueno, Clara, Montes, Rosa, Melen, Gustavo J, Ramos-Mejia, Verónica, Real, Pedro J, Ayllón, Verónica, Sanchez, Laura, Ligero, Gertrudis, Gutierrez-Aranda, Iván, Fernández, Agustín F, Fraga, Mario F, Moreno-Gimeno, Inmaculada, Burks, Deborah, del Carmen Plaza-Calonge, María, Rodríguez-Manzaneque, Juan C, Menendez, Pablo

“…The MLL-AF4 fusion gene is a hallmark genomic aberration in high-risk acute iymphoblastic leukemia in infants. Although it is well established that MLL-AF4…”
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SCL/TAL1 Regulates Hematopoietic Specification From Human Embryonic Stem Cells by Real, Pedro J, Ligero, Gertrudis, Ayllon, Veronica, Ramos-Mejia, Veronica, Bueno, Clara, Gutierrez-Aranda, Ivan, Navarro-Montero, Oscar, Lako, Majlinda, Menendez, Pablo

“…Determining the molecular regulators/pathways responsible for the specification of human embryonic stem cells (hESCs) into hematopoietic precursors has…”
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Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia by Montes, Rosa, Ayllón, Verónica, Gutierrez-Aranda, Ivan, Prat, Isidro, Hernández-Lamas, M. Carmen, Ponce, Laura, Bresolin, Silvia, te Kronnie, Geertruy, Greaves, Mel, Bueno, Clara, Menendez, Pablo

“…Infant acute lymphoblastic leukemia harboring the fusion mixed-lineage leukemia (MLL)-AF4 is associated with a dismal prognosis and very brief latency. Our…”
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Intra-bone marrow transplantation of human CD34+ cells into NOD/LtSz- scid IL-2rγnull mice permits multilineage engraftment without previous irradiation by Bueno, Clara, Montes, Rosa, de la Cueva, Teresa, Gutierrez-Aránda, Iván, Menendez, Pablo

“…Abstract Background aims Non-irradiated immunodeficient recipients provide the best physiologic setting for revealing hematopoietic stem cell (HSC) functions…”
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Intra-bone marrow transplantation of human CD34(+) cells into NOD/LtSz-scid IL-2rgamma(null) mice permits multilineage engraftment without previous irradiation by Bueno, Clara, Montes, Rosa, de la Cueva, Teresa, Gutierrez-Aránda, Iván, Menendez, Pablo

“…Non-irradiated immunodeficient recipients provide the best physiologic setting for revealing hematopoietic stem cell (HSC) functions after xenotransplantion…”
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