Search Results - "Gutierrez, Ramiro L."

Safety and immunogenicity of intramuscularly administered CS6 subunit vaccine with a modified heat-labile enterotoxin from enterotoxigenic Escherichia coli by Lee, Tida, Gutiérrez, Ramiro L., Maciel, Milton, Poole, Steven, Testa, Kayla J., Trop, Stefanie, Duplessis, Christopher, Lane, Alison, Riddle, Mark S., Hamer, Melinda, Alcala, Ashley, Prouty, Michael, Maier, Nicole, Erdem, Rahsan, Louis Bourgeois, A., Porter, Chad K.

“…Enterotoxigenic Escherichia coli (ETEC) is a common cause of infectious diarrhoea and a leading cause of morbidity and mortality in children living in…”
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Enterotoxigenic E. coli virulence gene regulation in human infections by Crofts, Alexander A., Giovanetti, Simone M., Rubin, Erica J., Poly, Frédéric M., Gutiérrez, Ramiro L., Talaat, Kawsar R., Porter, Chad K., Riddle, Mark S., DeNearing, Barbara, Brubaker, Jessica, Maciel, Milton, Alcala, Ashley N., Chakraborty, Subhra, Prouty, Michael G., Savarino, Stephen J., Davies, Bryan W., Trent, M. Stephen

“…Enterotoxigenic Escherichia coli (ETEC) is a global diarrheal pathogen that utilizes adhesins and secreted enterotoxins to cause disease in mammalian hosts…”
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Increased Risk of Functional Gastrointestinal Sequelae After Clostridium difficile Infection Among Active Duty United States Military Personnel (1998–2010) by Gutiérrez, Ramiro L, Riddle, Mark S, Porter, Chad K

“…Background & Aims Some acute enteric infections are associated with the development of functional gastrointestinal disorders, most commonly irritable bowel…”
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Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score by Porter, Chad K, Lynen, Amanda, Riddle, Mark S, Talaat, Kawsar, Sack, David, Gutiérrez, Ramiro L, McKenzie, Robin, DeNearing, Barbara, Feijoo, Brittany, Kaminski, Robert W, Taylor, David N, Kirkpatrick, Beth D, Bourgeois, A Louis

“…Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and…”
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A grading system for local skin reactions developed for clinical trials of an intradermal and transcutaneous ETEC vaccine by Gutiérrez, Ramiro L., Porter, Chad K., Jarell, Abel, Alcala, Ashley, Riddle, Mark S., Turiansky, George W.

“…•A cutaneous vaccine grading scale was useful to classify the appearance of cutaneous adverse events associated with the early testing of skin administered…”
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Gut microbiome and antibiotic resistance effects during travelers' diarrhea treatment and prevention by Blake, Kevin S, Schwartz, Drew J, Paruthiyil, Srinand, Wang, Bin, Ning, Jie, Isidean, Sandra D, Burns, Daniel S, Whiteson, Harris, Lalani, Tahaniyat, Fraser, Jamie A, Connor, Patrick, Troth, Tom, Porter, Chad K, Tribble, David R, Riddle, Mark S, Gutiérrez, Ramiro L, Simons, Mark P, Dantas, Gautam

“…The travelers' gut microbiome is potentially assaulted by acute and chronic perturbations (e.g., diarrhea, antibiotic use, and different environments). Prior…”
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Epidemiology and associated microbiota changes in deployed military personnel at high risk of traveler's diarrhea by Walters, William A, Reyes, Faviola, Soto, Giselle M, Reynolds, Nathanael D, Fraser, Jamie A, Aviles, Ricardo, Tribble, David R, Irvin, Adam P, Kelley-Loughnane, Nancy, Gutierrez, Ramiro L, Riddle, Mark S, Ley, Ruth E, Goodson, Michael S, Simons, Mark P

“…Travelers' diarrhea (TD) is the most prevalent illness encountered by deployed military personnel and has a major impact on military operations, from reduced…”
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Refinement of the CS6-expressing enterotoxigenic Escherichia coli strain B7A human challenge model: A randomized trial by Talaat, Kawsar R, Porter, Chad K, Jaep, Kayla M, Duplessis, Christopher A, Gutierrez, Ramiro L, Maciel, Jr, Milton, Adjoodani, Brittany, Feijoo, Brittany, Chakraborty, Subhra, Brubaker, Jessica, Trop, Stefanie A, Riddle, Mark S, Joseph, Sabrina S, Bourgeois, A Louis, Prouty, Michael G

“…Human challenge models for enterotoxigenic Escherichia coli (ETEC) facilitate vaccine down-selection. The B7A (O148:H28 CS6+LT+ST+) strain is important for…”
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A First in Human Clinical Trial Assessing the Safety and Immunogenicity of Two Intradermally Delivered Enterotoxigenic Escherichia coli CFA/I Fimbrial Tip Adhesin Antigens with and without Heat-Labile Enterotoxin with Mutation LT(R192G) by Gutiérrez, Ramiro L., Riddle, Mark S., Porter, Chad K., Maciel, Milton, Poole, Steven T., Laird, Renee M., Lane, Michelle, Turiansky, George W., Jarell, Abel, Savarino, Stephen J.

“…Introduction: Enterotoxigenic E. coli (ETEC) is a leading cause of diarrhea in travelers as well as for children living in low- to middle-income countries…”
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An Evidenced-Based Scale of Disease Severity following Human Challenge with Enteroxigenic Escherichia coli by Porter, Chad K, Riddle, Mark S, Alcala, Ashley N, Sack, David A, Harro, Clayton, Chakraborty, Subhra, Gutierrez, Ramiro L, Savarino, Stephen J, Darsley, Michael, McKenzie, Robin, DeNearing, Barbara, Steinsland, Hans, Tribble, David R, Bourgeois, A Louis

“…Experimental human challenge models have played a major role in enhancing our understanding of infectious diseases. Primary outcomes have typically utilized…”
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Efficacy Evaluation of an Intradermally Delivered Enterotoxigenic Escherichia coli CF Antigen I Fimbrial Tip Adhesin Vaccine Coadministered with Heat-Labile Enterotoxin with LT(R192G) against Experimental Challenge with Enterotoxigenic E. coli H10407 in Healthy Adult Volunteers by Gutiérrez, Ramiro L, Porter, Chad K, Harro, Clayton, Talaat, Kawsar, Riddle, Mark S, DeNearing, Barbara, Brubaker, Jessica, Maciel, Jr, Milton, Laird, Renee M, Poole, Steven, Chakraborty, Subra, Maier, Nicole, Sack, David A, Savarino, Stephen J

“…Enterotoxigenic (ETEC) is a principal cause of diarrhea in travelers, deployed military personnel, and children living in low to middle-income countries. ETEC…”
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Review: chronic and persistent diarrhea with a focus in the returning traveler by Duplessis, Christopher A, Gutierrez, Ramiro L, Porter, Chad K

“…Travelers' diarrhea is a common malady afflicting up to 50% of travelers after a 2-week travel period. An appreciable percentage of these cases will become…”
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Epidemiology of Clostridium difficile infection among active duty United States military personnel (1998-2010) by Gutiérrez, Ramiro L, Riddle, Mark S, Porter, Chad K

“…Clostridium difficile associated disease (CDAD) has risen in incidence and the experience in the US military has not been described. We evaluated the U.S…”
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Deployment Infectious Disease Threats: IDCRP Initiatives and Vision Forward by Lalani, Tahaniyat, Fraser, Jamie, Riddle, Mark S, Gutierrez, Ramiro L, Hickey, Patrick W, Tribble, David R

“…Abstract Background Infectious diseases pose a significant threat to health and readiness of military personnel deployed globally during wartime and…”
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Cohort profile of the PRoteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects (PREDICTS) study: Rationale, organization, design, and baseline characteristics by Porter, Chad K., Riddle, Mark S., Gutierrez, Ramiro L., Princen, Fred, Strauss, Rick, Telesco, Shannon E., Torres, Joana, Choung, Rok Seon, Laird, Renee M., Leon, Francisco, Colombel, Jean-Frédéric, Murray, Joseph A.

“…The etiology of Inflammatory Bowel Disease (IBD) remains currently unknown but evidence would suggest that it results from a complex interplay between genetic…”
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Rhabdomyolysis and pandemic (H1N1) 2009 pneumonia in adult by Gutierrez, Ramiro L, Ellis, Michael W, Decker, Catherine F

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Fever, dyspnea, and hepatitis in an Iraq veteran by Gutiérrez, Ramiro L, Hartzell, Joshua D

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Plasma and cerebrospinal fluid concentrations of cefiderocol during successful treatment of carbapenem-resistant Acinetobacter baumannii meningitis by Kufel, Wesley D, Abouelhassan, Yasmeen, Steele, Jeffrey M, Gutierrez, Ramiro L, Perwez, Talha, Bourdages, George, Nicolau, David P

“…Abstract Background To date, no real-world data are available to describe cefiderocol use in carbapenem-resistant Acinetobacter baumannii (CRAB) meningitis…”
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Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study by Riddle, Mark S, Kaminski, Robert W, Di Paolo, Claudio, Porter, Chad K, Gutierrez, Ramiro L, Clarkson, Kristen A, Weerts, Hailey E, Duplessis, Christopher, Castellano, Amy, Alaimo, Cristina, Paolino, Kristopher, Gormley, Robert, Gambillara Fonck, Veronica

“…Several candidate vaccines against Shigella spp. are in development, but the lack of a clear correlate of protection from challenge with the induction of…”
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Clinical endpoints for efficacy studies by Porter, Chad K., Gutierrez, Ramiro L., Kotloff, Karen L.

“…Well-established, validated and clinically meaningful primary and secondary endpoints are critical in advancing vaccines through proof of principal studies,…”
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