Search Results - "Gutierrez, Pablo"

An integrated modelling approach for targeted degradation: insights on optimization, data requirements and PKPD predictions from semi- or fully-mechanistic models and exact steady state solutions by Guzzetti, Sofia, Morentin Gutierrez, Pablo

“…The value of an integrated mathematical modelling approach for protein degraders which combines the benefits of traditional turnover models and fully…”
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Functional feeding groups of aquatic insect families in Latin America: a critical analysis and review of existing literature by Ramírez, Alonso, Gutiérrez-Fonseca, Pablo E

“…Aquatic macroinvertebrates are involved in numerous processes within aquatic ecosystems. They often have important effects on ecosystem processes such as…”
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Gender bias in clinical trials of biological agents for migraine: A systematic review by Alonso-Moreno, Marta, Rodríguez-de Francisco, Lupe, Ciudad-Gutiérrez, Pablo

“…Migraine is considered one of the most disabling diseases. Currently, there are few studies on clinical migraine treatment based on sex-related differences,…”
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SUMO control of nervous system development by García-Gutiérrez, Pablo, García-Domínguez, Mario

“…In the last decades, the post-translational modification system by covalent attachment of the SUMO polypeptide to proteins has emerged as an essential…”
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Gini and undercoverage at the upper tail: a simple approximation by Gutiérrez Cubillos, Pablo

“…This paper investigates the impact of top-distribution undercoverage on the Gini coefficient. First, we show that failing to correct for underreporting and…”
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An SIR-type epidemiological model that integrates social distancing as a dynamic law based on point prevalence and socio-behavioral factors by Cabrera, Maritza, Córdova-Lepe, Fernando, Gutiérrez-Jara, Juan Pablo, Vogt-Geisse, Katia

“…Modeling human behavior within mathematical models of infectious diseases is a key component to understand and control disease spread. We present a…”
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Wage inequality and economic growth. A reassessment of the effects of Francoist developmentalism on income distribution in Spain by Gutiérrez González, Pablo

“…The relationship between economic development and inequality has been closely examined by researchers. From the seminal work of Kuznets to the more recent work…”
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Gender bias in clinical trials of biological agents for severe asthma: A systematic review by Ciudad-Gutiérrez, Pablo, Fernández-Rubio, Beatriz, Guisado-Gil, Ana Belén

“…Asthma is one of the most common chronic diseases characterized by sex disparities. Gender bias is a well-documented issue detected in the design of published…”
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Inhibitory responses to retinohypothalamic tract stimulation in the circadian clock of the diurnal rodent Rhabdomys pumilio by Schoonderwoerd, Robin A., Torres Gutiérrez, Pablo, Blommers, Ruben, Beurden, Anouk W., Coenen, Tineke C. J. J., Klett, Nathan J., Michel, Stephan H., Meijer, Johanna H.

“…In both diurnal and nocturnal mammals, the timing of activity is regulated by the central circadian clock of the suprachiasmatic nucleus (SCN). The SCN is…”
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Cooperative binding of transcription factors promotes bimodal gene expression response by Gutierrez, Pablo S, Monteoliva, Diana, Diambra, Luis

“…In the present work we extend and analyze the scope of our recently proposed stochastic model for transcriptional regulation, which considers an arbitrarily…”
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Single cell model for re‐entrainment to a shifted light cycle by Beurden, Anouk W., Schoonderwoerd, Robin A., Tersteeg, Mayke M. H., Torres Gutiérrez, Pablo, Michel, Stephan, Blommers, Ruben, Rohling, Jos H. T., Meijer, Johanna H.

“…Our daily 24‐h rhythm is synchronized to the external light–dark cycle resulting from the Earth's daily rotation. In the mammalian brain, the suprachiasmatic…”
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Nonlinear risks: a unified framework by Gutiérrez Cubillos, Pablo, Pastén, Roberto

“…We study the conditions under which increasing risk raises the optimal control variable when the budget constraint is nonlinear. In contrast to the case when…”
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Migrants in transit through Mexico to the US: Experiences with violence and related factors, 2009-2015 by Leyva-Flores, René, Infante, Cesar, Gutierrez, Juan Pablo, Quintino-Perez, Frida, Gómez-Saldivar, MariaJose, Torres-Robles, Cristian

“…The objectives of the study are to 1) estimate the burden of physical, sexual, and psychological violence among migrants in transit through Mexico to the US;…”
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Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology by Goldberg, Frederick W., Kettle, Jason G., Lamont, Gillian M., Buttar, David, Ting, Attilla K. T., McGuire, Thomas M., Cook, Calum R., Beattie, David, Morentin Gutierrez, Pablo, Kavanagh, Stefan L., Komen, Jasper C., Kawatkar, Aarti, Clark, Roger, Hopcroft, Lorna, Hughes, Gareth, Critchlow, Susan E.

“…Due to increased reliance on glycolysis, which produces lactate, monocarboxylate transporters (MCTs) are often upregulated in cancer. MCT4 is associated with…”
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The classic metal‐sensing transcription factor MTF1 promotes myogenesis in response to copper by Tavera‐Montañez, Cristina, Hainer, Sarah J., Cangussu, Daniella, Gordon, Shellaina J. V., Xiao, Yao, Reyes‐Gutierrez, Pablo, Imbalzano, Anthony N., Navea, Juan G., Fazzio, Thomas G., Padilla‐Benavides, Teresita

“…Metal‐regulatory transcription factor 1 (MTF1) is a conserved metal‐binding transcription factor in eukaryotes that binds to conserved DNA sequence motifs,…”
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Distribution channels and growth strategies in Spanish insurance: from networks of agents to branch offices (1870-1940) by Pons Pons, Jerònia, Gutiérrez González, Pablo

“…This article analyses the factors that determined the choice of distribution channel within the Spanish insurance industry and its relation with growth…”
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Resilient or declining? An institutional analysis of employer associations and their implications for companies in the European Union by Sánchez-Mosquera, Marcial, Gutiérrez González, Pablo

“…Institutional transformations in recent decades have limited the weight and power of collective actors. Notwithstanding this, literature on employer…”
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Influence of river channel typology on aquatic macroinvertebrate assemblages in tropical streams by Quesada-Alvarado, Francisco, Gutiérrez-Fonseca, Pablo E., Solano-Ulate, Darha, Bermudez-Monge, Jenny, Jiménez-Fretes, Alejandra, Echevería-Sáenz, Silvia

“…River typology is determined by a set of hydrological and geomorphological characteristics, which can determine the structure of aquatic macroinvertebrate…”
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Combined or Sequential Treatment with Immune Checkpoint Inhibitors and Car-T Cell Therapies for the Management of Haematological Malignancies: A Systematic Review by Pérez-Moreno, María Antonia, Ciudad-Gutiérrez, Pablo, Jaramillo-Ruiz, Didiana, Reguera-Ortega, Juan Luis, Abdel-kader Martín, Laila, Flores-Moreno, Sandra

“…The aim of this paper was to review the available evidence on the efficacy and safety of combined or sequential use of PD-1/PD-L1 immune checkpoint inhibitors…”
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Rape, transactional sex and related factors among migrants in transit through Mexico to the USA by Infante, Cesar, Leyva-Flores, René, Gutierrez, Juan Pablo, Quintino-Perez, Frida, Torres-Robles, Cristian Armando, Gomez-Zaldívar, Mariajosé

“…Migrants in transit through Mexico to the USA are at risk of violence, including sexual violence, during the immigration process. This study sought to identify…”
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