Search Results - "Gutierrez, Kilian Jesús"

Leishmania infantum EndoG is an endo/exo-nuclease essential for parasite survival by Rico, Eva, Oliva, Cristina, Gutierrez, Kilian Jesús, Alzate, Juan Fernando, Genes, Carlos Mario, Moreno, David, Casanova, Elena, Gigante, Alba, Pérez-Pérez, María-Jesús, Camarasa, María-José, Clos, Joachim, Gago, Federico, Jiménez-Ruiz, Antonio

“…EndoG, a member of the DNA/RNA non-specific ββα-metal family of nucleases, has been demonstrated to be present in many organisms, including Trypanosomatids…”
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Novel hybrid selenosulfonamides as potent antileishmanial agents by Baquedano, Ylenia, Moreno, Esther, Espuelas, Socorro, Nguewa, Paul, Font, María, Gutierrez, Kilian Jesús, Jiménez-Ruiz, Antonio, Palop, Juan Antonio, Sanmartín, Carmen

“…Diselenide and sulfonamide derivatives have recently attracted considerable interest as leishmanicidal agents in drug discovery. In this study, a novel series…”
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The Vast Complexity of the Epigenetic Landscape during Neurodevelopment: An Open Frame to Understanding Brain Function by Cariaga-Martínez, Ariel Ernesto, Gutiérrez, Kilian Jesús, Alelú-Paz, Raúl

“…Development is a well-defined stage-to-stage process that allows the coordination and maintenance of the structure and function of cells and their progenitors,…”
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Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase by Revuelto, Alejandro, Ruiz-Santaquiteria, Marta, de Lucio, Héctor, Gamo, Ana, Carriles, Alejandra A, Gutiérrez, Kilian Jesús, Sánchez-Murcia, Pedro A, Hermoso, Juan A, Gago, Federico, Camarasa, María-José, Jiménez-Ruiz, Antonio, Velázquez, Sonsoles

“…Disruption of protein–protein interactions of essential oligomeric enzymes by small molecules represents a significant challenge. We recently reported some…”
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First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity by Ruiz-Santaquiteria, Marta, Sánchez-Murcia, Pedro A., Toro, Miguel A., de Lucio, Héctor, Gutiérrez, Kilian Jesús, de Castro, Sonia, Carneiro, Filipa A.C., Gago, Federico, Jiménez-Ruiz, Antonio, Camarasa, María-José, Velázquez, Sonsoles

“…A series of 9-mer and 13-mer amide-bridged cyclic peptides derived from the linear prototype Ac-PKIIQSVGIS-Nle-K-Nle-NH2 (Toro et al. ChemBioChem2013) has been…”
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Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability by Ruiz-Santaquiteria, Marta, de Castro, Sonia, Toro, Miguel A., de Lucio, Héctor, Gutiérrez, Kilian Jesús, Sánchez-Murcia, Pedro A., Jiménez, María Ángeles, Gago, Federico, Jiménez-Ruiz, Antonio, Camarasa, María-José, Velázquez, Sonsoles

“…Trypanothione reductase (TryR) is a well-established target in the search for novel antitrypanosomal and antileishmanial agents. We have previously identified…”
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Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides by de Lucio, Héctor, Gamo, Ana María, Ruiz-Santaquiteria, Marta, de Castro, Sonia, Sánchez-Murcia, Pedro A., Toro, Miguel A., Gutiérrez, Kilian Jesús, Gago, Federico, Jiménez-Ruiz, Antonio, Camarasa, María-José, Velázquez, Sonsoles

“…The objective of the current study was to enhance the proteolytic stability of peptide-based inhibitors that target critical protein-protein interactions at…”
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Leishmania infantum EndoG Is an Endo/Exo-Nuclease Essential for Parasite Survival: e89526 by Rico, Eva, Oliva, Cristina, Gutierrez, Kilian Jesus, Alzate, Juan Fernando, Genes, Carlos Mario, Moreno, David, Casanova, Elena, Gigante, Alba, Perez-Perez, Maria-Jesus, Camarasa, Maria-Jose

“…EndoG, a member of the DNA/RNA non-specific beta beta alpha -metal family of nucleases, has been demonstrated to be present in many organisms, including…”
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