Search Results - "Gutierrez, Giselle Dominguez"

Gene Signature of Proliferating Human Pancreatic α Cells by Dominguez Gutierrez, Giselle, Xin, Yurong, Okamoto, Haruka, Kim, Jinrang, Lee, Ann-Hwee, Ni, Min, Adler, Christina, Yancopoulos, George D, Murphy, Andrew J, Gromada, Jesper

“…Pancreatic α cells proliferate at a low rate, and little is known about the control of this process. Here we report the characterization of human α cells by…”
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Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development by Churchill, Angela J, Gutiérrez, Giselle Dominguez, Singer, Ruth A, Lorberbaum, David S, Fischer, Kevin A, Sussel, Lori

“…Many pancreatic transcription factors that are essential for islet cell differentiation have been well characterized; however, because they are often expressed…”
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Pancreatic β cell identity requires continual repression of non-β cell programs by Gutiérrez, Giselle Domínguez, Bender, Aaron S, Cirulli, Vincenzo, Mastracci, Teresa L, Kelly, Stephen M, Tsirigos, Aristotelis, Kaestner, Klaus H, Sussel, Lori

“…Loss of β cell identity, the presence of polyhormonal cells, and reprogramming are emerging as important features of β cell dysfunction in patients with type 1…”
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Heterogeneity of human pancreatic β-cells by Dominguez-Gutierrez, Giselle, Xin, Yurong, Gromada, Jesper

“…Human pancreatic β-cells are heterogeneous. This has been known for a long time and is based on various functional and morphological readouts. β-Cell…”
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Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic α-Cells After Glucagon Receptor Inhibition by Kim, Jinrang, Dominguez Gutierrez, Giselle, Xin, Yurong, Cavino, Katie, Sung, Biin, Sipos, Bence, Kloeppel, Guenter, Gromada, Jesper, Okamoto, Haruka

“…Plasma amino acids and their transporters constitute an important part of the feedback loop between the liver and pancreatic α-cell function, and glucagon…”
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Gene Signature of the Human Pancreatic ε Cell by Dominguez Gutierrez, Giselle, Kim, Jinrang, Lee, Ann-Hwee, Tong, Jenny, Niu, JingJing, Gray, Sarah M, Wei, Yi, Ding, Yueming, Ni, Min, Adler, Christina, Murphy, Andrew J, Gromada, Jesper, Xin, Yurong

“…The ghrelin-producing ε cell represents the fifth endocrine cell type in human pancreatic islets. The abundance of ε cells in adult pancreas is extremely low,…”
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Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response by Xin, Yurong, Dominguez Gutierrez, Giselle, Okamoto, Haruka, Kim, Jinrang, Lee, Ann-Hwee, Adler, Christina, Ni, Min, Yancopoulos, George D, Murphy, Andrew J, Gromada, Jesper

“…Proinsulin is a misfolding-prone protein, making its biosynthesis in the endoplasmic reticulum (ER) a stressful event. Pancreatic β-cells overcome ER stress by…”
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Heterogeneity of the Pancreatic Beta Cell by Gutierrez, Giselle Dominguez, Gromada, Jesper, Sussel, Lori

“…The pancreatic beta cell functions as a key regulator of blood glucose levels by integrating a variety of signals in response to changing metabolic demands…”
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An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease by Munkacsi, Andrew B., Chen, Fannie W., Brinkman, Matthew A., Higaki, Katsumi, Gutiérrez, Giselle Domínguez, Chaudhari, Jagruti, Layer, Jacob V., Tong, Amy, Bard, Martin, Boone, Charles, Ioannou, Yiannis A., Sturley, Stephen L.

“…Niemann-Pick type C (NP-C) disease is a fatal lysosomal lipid storage disorder for which no effective therapy exists. A genome-wide, conditional synthetic…”
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Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity by Kleiner, Sandra, Gomez, Daniel, Megra, Bezawit, Na, Erqian, Bhavsar, Ramandeep, Cavino, Katie, Xin, Yurong, Rojas, Jose, Dominguez-Gutierrez, Giselle, Zambrowicz, Brian, Carrat, Gaelle, Chabosseau, Pauline, Hu, Ming, Murphy, Andrew J., Yancopoulos, George D., Rutter, Guy A., Gromada, Jesper

“…SLC30A8 encodes a zinc transporter that is primarily expressed in the pancreatic islets of Langerhans. In β-cells it transports zinc into insulin-containing…”
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Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic [alpha]-Cells After Glucagon Receptor Inhibition by Kim, Jinrang, Gutierrez, Giselle Dominguez, Xin, Yurong, Cavino, Katie, Sung, Biin, Sipos, Bence, Kloeppel, Guenter, Gromada, Jesper, Okamoto, Haruka

“…Plasma amino acids and their transporters constitute an important part of the feedback loop between the liver and pancreatic [alpha]-cell function, and…”
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Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency by Altarejos, Judith Y, Pangilinan, Jeffrey, Podgrabinska, Simona, Akinci, Baris, Foss-Freitas, Maria, Neidert, Adam H, Ray, Yonaton, Zheng, Wenjun, Kim, Steven, Kamat, Vishal, Huang, Meilin, Min, Soo, Mastaitis, Jason, Dominguez-Gutierrez, Giselle, Kim, Jee-Hae, Stevis, Panayiotis, Huang, Tammy, Zambrowicz, Brian, Olson, William C, Godin, Stephen, Bradley, Elizabeth, Gewitz, Andrew D, Baker, Mark, Hench, Rita, Davenport, Matthew S, Chenevert, Thomas L, DiPaola, Frank, Yancopoulos, George D, Murphy, Andrew J, Herman, Gary A, Musser, Bret J, Dansky, Hayes, Harp, Joyce, Gromada, Jesper, Sleeman, Mark W, Oral, Elif A, Olenchock, Benjamin A

“…Deficiency in the adipose-derived hormone leptin or leptin receptor signaling causes class 3 obesity in individuals with genetic loss-of-function mutations in…”
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Maintenance of Beta Cell Identity and Function by Dominguez Gutierrez, Giselle

“…The acquisition of beta cell identity and function is a multistage process that involves the sequential regulation of specific factors and signals. The…”
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Pancreatic [Beta] cell identity requires continual repression of non-[Beta] cell programs by Gutiérrez, Giselle Domínguez, Bender, Aaron S, Cirulli, Vincenzo, Mastracci, Teresa L, Kelly, Stephen M, Tsirigos, Aristotelis, Kaestner, Klaus H, Sussel, Lori

“…Loss of β cell identity, the presence of polyhormonal cells, and reprogramming are emerging as important features of β cell dysfunction in patients with type 1…”
Get full text