Search Results - "Gutierrez, Arnold J."

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines by Wagner, Richard W., Matteucci, Mark D., Lewis, Jason G., Gutierrez, Arnold J., Moulds, Courtney, Froehler, Brian C.

“…Phosphorothioate oligodeoxynucleotides containing the C-5 propyne analogs of uridine and cytidine bind RNA with high affinity and are potent antisense…”
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Preparation of Perhydroisoquinolines via the Intramolecular Diels−Alder Reaction of N-3,5-Hexadienoyl Ethyl Acrylimidates:  A Formal Synthesis of (±)-Reserpine by Sparks, Steven M, Gutierrez, Arnold J, Shea, Kenneth J

“…The intramolecular Diels−Alder reaction of N-3,5-hexadienoyl ethyl acrylimidates provides an efficient method for the synthesis of cis-fused…”
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5-Heteroaryl-2'-deoxyuridine Analogs. Synthesis and Incorporation into High-Affinity Oligonucleotides by Gutierrez, Arnold J, Terhorst, Terry J, Matteucci, Mark D, Froehler, Brian C

“…A series of C-5 heteroaryl-2'-deoxyuridines were synthesized from 5-iodo-2'-deoxyuridine. Palladium catalyzed coupling with heteroarylstannanes proved to be a…”
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Antisense Gene Inhibition by C-5-Substituted Deoxyuridine-Containing Oligodeoxynucleotides by Gutierrez, Arnold J, Matteucci, Mark D, Grant, Deborah, Matsumura, Sandra, Wagner, Richard W, Froehler, Brian C

“…Antisense oligodeoxynucleotides (ODNs) are capable of inhibiting gene expression via a RNase H mechanism in which the complementary RNA is degraded by RNase H…”
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The intramolecular Diels-Alder cycloaddition of N-dienoyl acrylimidates. An efficient approach for the synthesis of hexahydroisoquinolones and hexahydroisoindolones by Gutierrez, Arnold J, Shea, Kenneth J, Svoboda, John J

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RNA Duplex formation by oligodeoxynucleotides containing C-5 alkyne and C-5 thiazole substituted deoxyuridine analogs by Gutierrez, Arnold J., Froehler, Brian C.

“…The binding affinity of methyl substituted C-5 propyne and C-5 thiazole ODNs for RNA was assessed by thermal denaturation analysis (Tm). The results indicate…”
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