Search Results - "Guthrie, Patrick"

Decreased long‐chain fatty acid oxidation impairs postischemic recovery of the insulin‐resistant rat heart by Harmancey, Romain, Vasquez, Hernan G., Guthrie, Patrick H., Taegtmeyer, Heinrich

“…Diabetic patients with acute myocardial infarction are more likely to die than nondiabetic patients. In the present study we examined the effect of insulin…”
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Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy by Davogustto, Giovanni E., Salazar, Rebecca L., Vasquez, Hernan G., Karlstaedt, Anja, Dillon, William P., Guthrie, Patrick H., Martin, Joseph R., Vitrac, Heidi, De La Guardia, Gina, Vela, Deborah, Ribas-Latre, Aleix, Baumgartner, Corrine, Eckel-Mahan, Kristin, Taegtmeyer, Heinrich

“…The nutrient sensing mechanistic target of rapamycin complex 1 (mTORC1) and its primary inhibitor, tuberin (TSC2), are cues for the development of cardiac…”
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Insulin resistance improves metabolic and contractile efficiency in stressed rat heart by Harmancey, Romain, Lam, Truong N., Lubrano, Genna M., Guthrie, Patrick H., Vela, Deborah, Taegtmeyer, Heinrich

“…ABSTRACT Insulin resistance is a prominent feature in heart failure, while hyperglycemia impairs cardiac contraction. We propose that decreased…”
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Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart by SHARMA, Saumya, GUTHRIE, Patrick H, CHAN, Suzanne S, HAQ, Syed, TAEGTMEYER, Heinrich

“…Insulin regulates both glucose uptake and postnatal cardiac growth. The anabolic effects of insulin are mediated by the mammalian target of rapamycin (mTOR),…”
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Expression of neuropeptides and cytokines in a rabbit model of diabetic neuroischemic wound healing by Pradhan Nabzdyk, Leena, PhD, Kuchibhotla, Sarada, BS, Guthrie, Patrick, BS, Chun, Maggie, BA, Auster, Michael E., BA, Nabzdyk, Christoph, MD, Deso, Steven, MD, Andersen, Nicholas, MD, Gnardellis, Charalambos, PhD, LoGerfo, Frank W., MD, Veves, Aristidis, MD, DSc

“…Objective The present study is designed to understand the contribution of peripheral vascular disease and peripheral neuropathy to the wound-healing impairment…”
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Gene Expression of Pro-Inflammatory Cytokines and Neuropeptides in Diabetic Wound Healing by Pradhan, Leena, Ph.D, Cai, Xuemei, M.D, Wu, Szuhuei, B.S, Andersen, Nicholas D., M.D, Martin, Michelle, M.D, Malek, Junaid, M.D, Guthrie, Patrick, B.S, Veves, Aristidis, M.D., D.Sc, LoGerfo, Frank W., M.D

“…The interaction between neuropeptides and cytokines and its role in cutaneous wound healing is becoming evident. The goal of the present study is to…”
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Glucose Regulation of Load‐Induced mTOR Signaling and ER Stress in Mammalian Heart by Sen, Shiraj, Kundu, Bijoy K., Wu, Henry Cheng‐Ju, Hashmi, S. Shahrukh, Guthrie, Patrick, Locke, Landon W., Roy, R. Jack, Matherne, G. Paul, Berr, Stuart S., Terwelp, Matthew, Scott, Brian, Carranza, Sylvia, Frazier, O. Howard, Glover, David K., Dillmann, Wolfgang H., Gambello, Michael J., Entman, Mark L., Taegtmeyer, Heinrich

“…Background Changes in energy substrate metabolism are first responders to hemodynamic stress in the heart. We have previously shown that hexose‐6‐phosphate…”
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Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart by YOUNG, Martin E, GUTHRIE, Patrick H, RAZEGHI, Peter, LEIGHTON, Brendan, ABBASI, Shahrzad, PATIL, Sarita, YOUKER, Keith A, TAEGTMEYER, Heinrich

“…Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart Martin E. Young 1 , Patrick H. Guthrie 1 , Peter Razeghi 1 ,…”
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Effect of hyperglycemia and neuropeptides on interleukin-8 expression and angiogenesis in dermal microvascular endothelial cells by Jain, Monica, BS, LoGerfo, Frank W., MD, Guthrie, Patrick, BS, Pradhan, Leena, PhD

“…Background Impaired wound healing is a major complication associated with diabetes, involving a dysregulation and impairments in the inflammatory and…”
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Intrinsic Diurnal Variations in Cardiac Metabolism and Contractile Function by Young, Martin E, Razeghi, Peter, Cedars, Ari M, Guthrie, Patrick H, Taegtmeyer, Heinrich

“…Diurnal variation of cardiac function in vivo has been attributed primarily to changes in factors such as sympathetic activity. No study has investigated…”
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Perivesical unicentric Castleman disease initially suspected to be metastatic prostate cancer by Guthrie, Patrick, Thomas, John, Peker, Deniz, Turkbey, Baris, Rais-Bahrami, Soroush

“…Unicentric Castleman disease (UCD) is a relatively rare lymphoproliferative disease, which commonly presents as a mediastinal mass and less frequently involves…”
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Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury by Bhasin, Manoj, Huang, Zhen, Pradhan-Nabzdyk, Leena, Malek, Junaid Y, LoGerfo, Philip J, Contreras, Mauricio, Guthrie, Patrick, Csizmadia, Eva, Andersen, Nicholas, Kocher, Olivier, Ferran, Christiane, LoGerfo, Frank W

“…Vein graft failure occurs between 1 and 6 months after implantation due to obstructive intimal hyperplasia, related in part to implantation injury. The…”
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Alterations of the Circadian Clock in the Heart by Streptozotocin-induced Diabetes by Young, Martin E., Wilson, Christopher R., Razeghi, Peter, Guthrie, Patrick H., Taegtmeyer, Heinrich

“…The heart, like other organs, possesses an internal circadian clock. These clocks provide the selective advantage of anticipation, enabling the organ to…”
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Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice by Essop, M Faadiel, Camp, Heidi S, Choi, Cheol Soo, Sharma, Saumya, Fryer, Ryan M, Reinhart, Glenn A, Guthrie, Patrick H, Bentebibel, Assia, Gu, Zeiwei, Shulman, Gerald I, Taegtmeyer, Heinrich, Wakil, Salih J, Abu-Elheiga, Lutfi

“…The cardiac-enriched isoform of acetyl-CoA carboxylase (ACC2) is a key regulator of mitochondrial fatty acid (FA) uptake via carnitine palmitoyltransferase 1…”
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Mammalian Target of Rapamycin and Protein Kinase A Signaling Mediate the Cardiac Transcriptional Response to Glutamine by Xia, Yang, Wen, Hong Y, Young, Martin E, Guthrie, Patrick H, Taegtmeyer, Heinrich, Kellems, Rodney E

“…The addition of glutamine as a major nutrient to cultured neonatal rat cardiomyocytes produced an increase in myocyte size and the organization of actin into…”
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Proposed Regulation of Gene Expression by Glucose in Rodent Heart by Young, Martin E., Yan, Jie, Razeghi, Peter, Cooksey, Robert C., Guthrie, Patrick H., Stepkowski, Stanislaw M., McClain, Donald A., Tian, Rong, Taegtmeyer, Heinrich

“…1Martin E. Young, 2Jie Yan, 3Peter Razeghi, 4Robert C. Cooksey, 3Patrick H. Guthrie, 5Stanislaw M. Stepkowski, 4Donald A. McClain, 2Rong Tian and 3Heinrich…”
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Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids by Young, M E, Goodwin, G W, Ying, J, Guthrie, P, Wilson, C R, Laws, F A, Taegtmeyer, H

“…Malonyl-CoA decarboxylase (MCD) catalyzes the degradation of malonyl-CoA, an important modulator of fatty acid oxidation. We hypothesized that increased fatty…”
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Proteome Analysis of Isolated Perfused Organ Effluent as a Novel Model for Protein Biomarker Discovery by Koomen, John M, Wilson, Christopher R, Guthrie, Patrick, Androlewicz, Matthew J, Kobayashi, Ryuji, Taegtmeyer, Heinrich

“…The discovery of novel serological biomarkers is critical for improving disease diagnosis and monitoring treatment response. Proteomic analysis of model…”
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Glutamine cycling in isolated working rat heart by Cohen, David M, Guthrie, Patrick H, Gao, Xiaolian, Sakai, Ryosei, Taegtmeyer, Heinrich

“…To what extent does glutamine turnover keep pace with oxidative metabolism in the rat heart? To address this question, the following groups of substrates were…”
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TUBERIN DELETION REPLICATES EXERCISE-INDUCED CARDIAC HYPERTROPHY by Davogustto, Giovanni, Salazar, Rebecca, Vasquez, Hernan, Guthrie, Patrick, Taegtmeyer, Heinrich

“…[...]cardiomyocyte hypertrophy, improvement in systolic function, and decrease in GPI levels were reversed with rapamycin treatment, confirming these effects…”
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