Search Results - "Gustin, P."

PIK3CA and AKT1 Mutations Have Distinct Effects on Sensitivity to Targeted Pathway Inhibitors in an Isogenic Luminal Breast Cancer Model System by BEAVER, Julia A, GUSTIN, John P, YI, Kyung H, RAJPUROHIT, Anandita, THOMAS, Matthew, GILBERT, Samuel F, MARC ROSEN, D, PARK, Ben Ho, LAURING, Josh

“…Activating mutations in the phosphoinositide-3-kinase (PI3K)/AKT/mTOR pathway are present in the majority of breast cancers and therefore are a major focus of…”
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Systematic Review of Efficacy of Nutraceuticals to Alleviate Clinical Signs of Osteoarthritis by Vandeweerd, J.‐M., Coisnon, C., Clegg, P., Cambier, C., Pierson, A., Hontoir, F., Saegerman, C., Gustin, P., Buczinski, S.

“…Background Various treatments of osteoarthritis (OA) have been described, including use of nutraceuticals. Objectives To review systematically the literature…”
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Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells by Konishi, Hiroyuki, Mohseni, Morassa, Tamaki, Akina, Garay, Joseph P, Croessmann, Sarah, Karnan, Sivasundaram, Ota, Akinobu, Wong, Hong Yuen, Konishi, Yuko, Karakas, Bedri, Tahir, Khola, Abukhdeir, Abde M, Gustin, John P, Cidado, Justin, Wang, Grace M, Cosgrove, David, Cochran, Rory, Jelovac, Danijela, Higgins, Michaela J, Arena, Sabrina, Hawkins, Lauren, Lauring, Josh, Gross, Amy L, Heaphy, Christopher M, Hosokawa, Yositaka, Gabrielson, Edward, Meeker, Alan K, Visvanathan, Kala, Argani, Pedram, Bachman, Kurtis E, Park, Ben Ho

“…Biallelic inactivation of cancer susceptibility gene BRCA1 leads to breast and ovarian carcinogenesis. Paradoxically, BRCA1 deficiency in mice results in early…”
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The multiple myeloma–associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity by Lauring, Josh, Abukhdeir, Abde M., Konishi, Hiroyuki, Garay, Joseph P., Gustin, John P., Wang, Qiuju, Arceci, Robert J., Matsui, William, Park, Ben Ho

“…Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal translocations. Patients with t(4;14)(p16;q32) are the…”
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Hydrophobically-Modified Chitosan Gauze: A Novel Topical Hemostat by Chaturvedi, Apurva, Dowling, Matthew B., Ph.D, Gustin, John P., Ph.D, Scalea, Thomas M., M.D, Raghavan, Srinivasa R., Ph.D, Pasley, Jason D., D.O, Narayan, Mayur, M.D, M.P.H, M.B.A

“…Abstract Background Currently, the standard of care for treating severe hemorrhage in a military setting is Combat GauzeTM (CG). Previous work has shown that…”
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French Sleepiness Scale for Adolescents-8 items: A discriminant and diagnostic validation by Gustin, M-P, Putois, B, Guyon, A, Lecendreux, M, Challamel, M-J, Plancoulaine, S, Bioulac-Rogier, S, Schroder, C, Royant-Parola, S, Huguelet, S, Franco, P

“…The objective of the present study was to validate the Short Version of French Sleepiness Scale for Adolescents (FSSA) with eight items (FSSA8). A total of 384…”
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Knockin of mutant PIK3CA activates multiple oncogenic pathways by Gustin, John P, Karakas, Bedri, Weiss, Michele B, Abukhdeir, Abde M, Lauring, Josh, Garay, Joseph P, Cosgrove, David, Tamaki, Akina, Konishi, Hiroyuki, Konishi, Yuko, Mohseni, Morassa, Wang, Grace, Rosen, D. Marc, Denmeade, Samuel R, Higgins, Michaela J, Vitolo, Michele I, Bachman, Kurtis E, Park, Ben Ho

“…The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to "knock in" PIK3CA mutations into human…”
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Vesicle−Biopolymer Gels:  Networks of Surfactant Vesicles Connected by Associating Biopolymers by Lee, Jae-Ho, Gustin, John P, Chen, Tianhong, Payne, Gregory F, Raghavan, Srinivasa R

“…The effect of adding an associating biopolymer to surfactant vesicles and micelles is studied using rheology and small-angle neutron scattering (SANS). The…”
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Samaras and seedlings of Acer pseudoplatanus are potential sources of hypoglycin A intoxication in atypical myopathy without necessarily inducing clinical signs by Baise, E., Habyarimana, J. A., Amory, H., Boemer, F., Douny, C., Gustin, P., Marcillaud-Pitel, C., Patarin, F., Weber, M., Votion, D.-M.

“…Summary Reasons for performing study Ingestion of sycamore seeds (Acer pseudoplatanus) is the likely source of hypoglycin A in atypical myopathy (AM) but…”
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Hafnium oxide nanoparticles activated by SBRT: a new interventional radiation therapy approach for the treatment of unresectable liver cancers by De Baere, T., Pracht, M., Rolland, Y., Nguyen, F., Bronowicki, J., Vendrely, V., Cunha, A. Sa, Baumann, A., Croisé-Laurent, V., Rio, E., Sourd, S. Le, Gustin, P., Perret, C., Peiffert, D., Deutsch, E., Chajon, E.

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In vitro orthodontic bracket bonding to porcelain by Al-Hity, R, Gustin, M-P, Bridel, N, Morgon, L, Grosgogeat, B

“…This in vitro study investigated the influence of using different combinations of bracket, adhesive, and light-curing source on the tensile bond strength to…”
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Single Copies of Mutant KRAS and Mutant PIK3CA Cooperate in Immortalized Human Epithelial Cells to Induce Tumor Formation by WANG, Grace M, YUEN WONG, Hong, GARAY, Joseph P, MOHSENI, Morassa, HIGGINS, Michaela J, CIDADO, Justin, JELOVAC, Danijela, CROESSMANN, Sarah, COCHRAN, Rory L, KARNAN, Sivasundaram, KONISHI, Yuko, OTA, Akinobu, KONISHI, Hiroyuki, HOSOKAWA, Yoshitaka, ARGANI, Pedram, LAURING, Josh, HO PARK, Ben, BLAIR, Brian G, ABUKHDEIR, Abde M, GUSTIN, John P, MARC ROSEN, D, RAY DENMEADE, Samuel, RASHEED, Zeshaan, MATSUI, William

“…The selective pressures leading to cancers with mutations in both KRAS and PIK3CA are unclear. Here, we show that somatic cell knockin of both KRAS G12V and…”
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Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine by Yi, Kyung H, Axtmayer, Jossette, Gustin, John P, Rajpurohit, Anandita, Lauring, Josh

“…The phosphatidylinositol 3-kinase (PI3-kinase)-Akt-mTOR pathway is mutated at high frequency in human breast cancer, and this pathway is the focus of active…”
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Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras-mediated transformation by KONISHI, Hiroyuki, KARAKAS, Bedri, ABUKHDEIR, Abde M, LAURING, Josh, GUSTIN, John P, GARAY, Joseph P, KONISHI, Yuko, GALLMEIER, Eike, BACHMAN, Kurtis E, BEN HO PARK

“…The oncogenic function of mutant ras in mammalian cells has been extensively investigated using multiple human and animal models. These systems include…”
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A phase I/II trial of hafnium oxide nanoparticles activated by radiotherapy in hepatocellular carcinoma and liver metastasis by Chajon, E., Pracht, M., De Baere, T., Nguyen, F., Bronowicki, J., Vendrely, V., Baumann, A., Croisé-Laurent, V., Rio, E., Rolland, Y., Le Sourd, S., Gustin, P., Perret, C., Mornex, F., Peiffert, D., Merle, P., Deutsch, E.

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Hepatocellular carcinoma and liver metastasis treated by hafnium oxide nanoparticles activated by stereotactic body radiation therapy by Pracht, M., Chajon, E., de Baere, T., Nguyen, F., Bronowicki, J.-P., Vendrely, V., Baumann, A.-S., Croisé-Laurent, V., Rio, E., Rolland, Y., Le Sourd, S., Gustin, P., Perret, C., Mornex, F., Peiffert, D., Merle, P., Deutsch, E.

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SIMMEON-Prep study: SIMulation of Medication Errors in ONcology: prevention of antineoplastic preparation errors by Sarfati, L., Ranchon, F., Vantard, N., Schwiertz, V., Gauthier, N., He, S., Kiouris, E., Gourc-Berthod, C., Guédat, M. G., Alloux, C., Gustin, M.-P., You, B., Trillet-Lenoir, V., Freyer, G., Rioufol, C.

“…Summary What is known and objective Medication errors (ME) in oncology are known to cause serious iatrogenic complications. However, MEs still occur at each…”
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Prevalence of naturally occurring cartilage defects in the ovine knee by Vandeweerd, J.-M, Hontoir, F, Kirschvink, N, Clegg, P, Nisolle, J.-F, Antoine, N, Gustin, P

“…Summary Objective To determine the prevalence, anatomical location and severity of cartilage defects in the stifle (knee) within a population of adult ewes ( N…”
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Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations by Lauring, J, Cosgrove, D P, Fontana, S, Gustin, J P, Konishi, H, Abukhdeir, A M, Garay, J P, Mohseni, M, Wang, G M, Higgins, M J, Gorkin, D, Reis, M, Vogelstein, B, Polyak, K, Cowherd, M, Buckhaults, P J, Park, B H

“…An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon, and ovarian cancers. The low frequency of this mutation…”
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Therapeutic options for oligoprogressive non-small cell lung cancer by Gustin, P, Botticella, A, Tselikas, L, Mercier, O, Le Péchoux, C, Levy, A

“…Lung cancer is the leading cause of cancer-related mortality and more than half of the cases are diagnosed at a metastatic stage. Major progress in terms of…”
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