Search Results - "Gustchina, A"

ATP-Dependent Lon Proteases in the Cellular Protein Quality Control System by Kudzhaev, A. M., Andrianova, A. G., Gustchina, A. E., Smirnov, I. V., Rotanova, T. V.

“…The Protein Quality Control (PQC) system plays a leading role in maintaining the safety of the cellular proteome in all natural kingdoms. This review…”
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Involvement of the N Domain Residues E34, K35, and R38 in the Functionally Active Structure of Escherichia coli Lon Protease by Andrianova, A G, Kudzhaev, A M, Abrikosova, V A, Gustchina, A E, Smirnov, I V, Rotanova, T V

“…ATP-dependent Lon protease of ( Lon), which belongs to the superfamily of AAA proteins, is a key component of the cellular proteome quality control system. It…”
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Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes by Wlodawer, Alexander, Li, Mi, Dauter, Zbigniew, Gustchina, Alla, Uchida, Kenichi, Oyama, Hiroshi, Dunn, Ben M, Oda, Kohei

“…The crystal structure of a pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. 101 (PSCP) has been solved by single-wavelength anomalous diffraction…”
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Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon γ by Zdanov, Alexander, Schalk-Hihi, Céline, Gustchina, Alla, Tsang, Monica, Weatherbee, James, Wlodawer, Alexander

“…Background: Interleukin (IL)-10 is a cytokine that inhibits production of other regulatory factors, including interferon γ (IFN γ) and IL-2. A dimer of IL-10…”
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Inhibitor Complexes of the Pseudomonas Serine-Carboxyl Proteinase by Wlodawer, Alexander, Li, Mi, Gustchina, Alla, Dauter, Zbigniew, Uchida, Kenichi, Oyama, Hiroshi, Goldfarb, Nathan E, Dunn, Ben M, Oda, Kohei

“…Crystal structures of the serine-carboxyl proteinase from Pseudomonas sp. 101 (PSCP), complexed with a number of inhibitors, have been solved and refined at…”
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The X-Ray Crystal Structure of Two Complexes of the Cockroach Allergen Bla g 2 with Fragments of Monoclonal Antibodies Defines Two Non-overlapping Epitopes by Pomés, A, Li, M, Glesner, J, Wünschmann, S, King, E.M, Chapman, M.D, Wlodawer, A, Gustchina, A

“…Analysis of the crystal structure of Bla g 2-Fab/Fab'-mAb complexes enables the identification of antigenic determinants on the allergen and subsequent…”
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Crystallographic and Biochemical Investigations of Kumamolisin-As, a Serine-Carboxyl Peptidase with Collagenase Activity by Wlodawer, Alexander, Li, Mi, Gustchina, Alla, Tsuruoka, Naoki, Ashida, Masako, Minakata, Hiroyuki, Oyama, Hiroshi, Oda, Kohei, Nishino, Tokuzo, Nakayama, Toru

“…Kumamolisin-As (previously called ScpA) is the first known example of a collagenase from the sedolisin family (MEROPS S53). This enzyme is active at low pH and…”
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Does the Structural Symmetry of Cockroach Allergen Bla g 2 Determine Symmetry of Antigenic Determinants for IgE antibody Binding? by Stohr, L, Wünschmann, S, Chapman, M.D, Li, M, Wlodawer, A, Gustchina, A, Pomés, A

“…Rationale Bla g 2 is a potent German cockroach allergen, homologous to aspartic proteases and has a bilobal three-dimensional structure, originated from gene…”
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Cockroach Allergen Bla g 2 Dimerizes in a Crystal Complex with an Antibody Fragment by Pomés, A, Li, M, Wünschmann, S, Chapman, M.D, Wlodawer, A, Gustchina, A

“…Determination of the molecular structure of a Bla g 2-Fab' complex enables a rational approach to study the effect of dimerization on allergenicity and…”
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Mapping of Antigenic Determinants on Bla g 2 surface by Wünschmann, S, Li, M, Gustchina, A, Wlodawer, A, Chapman, M, Pomés, A

“…Based on the mAb-allergen interaction from the crystal structure, two additional Bla g 2 mutants with multiple amino acid changes were created to eliminate the…”
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The Crystal Structure of the Complex of Bla g 2 with an Antibody Fragment Reveals Cation-pi and Sugar Interactions by Pomés, A, Li, M, Wünschmann, S, King, E.M, Alexandratos, J, Chapman, M.D, Wlodawer, A, Gustchina, A

“…Conclusions Analysis of the allergen-antibody interactions from the crystal structure of a Bla g 2-Fab' complex enables a rational approach for the design of…”
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Functional study of the cockroach allergen Bla g 2 by Wünschmann, S., Chapman, M.D., Gustchina, A., Wlodawer, A., Li, M., Pomés, A.

“…Inhibition by pepstatin, but not PMSF (a serine protease inhibitor) indicated that the activity was aspartic proteinase…”
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High resolution crystal structure of Bla g 2: A zinc binding cockroach allergen by Pomés, A., Li, M., Wünschmann, S., Chapman, M.D., Wlodawer, A., Gustchina, A.

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Ligand binding: An intrinsic property of cockroach allergen Bla g 2? by Wuenschmann, S., Li, M., Gustchina, A., Chapman, M.D., Pomes, A.

“…Bla g 2 is an inactive aspartic protease similar to pregnancy-associated glycoproteins. We investigated the effects of amino acid substitutions in the…”
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Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate by Wlodawer, Alexander, Li, Mi, Gustchina, Alla, Oyama, Hiroshi, Oda, Kohei, Beyer, Bret B, Clemente, Jose, Dunn, Ben M

“…High-resolution crystallographic analysis of a complex of the serine-carboxyl proteinase sedolisin with pseudo-iodotyrostatin revealed two molecules of this…”
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Structural and functional studies of Bacillus subtilis LonBA, member of a newly identified subfamily of Lon proteases by Gustchina, A., Li, M., Sekula, B., Cherry, S., Lountos, G., Andrianova, A., Kudzhaev, A., Tropea, J., Smirnov, I., Rotanova, T., Wlodawer, A.

“…Abstract only…”
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Toward a universal inhibitor of retroviral proteases: Comparative analysis of the interactions of LP‐130 complexed with proteases from HIV‐1, FIV, and EIAV by Kervinen, Jukka, Lubkowski, Jacek, Zdanov, Alexander, Bhatt, Deepa, Dunn, Ben M., Hui, Kwan Y., Powell, David J., Kay, John, Wlodawer, Alexander, Gustchina, Alla

“…One of the major problems encountered in antiviral therapy against AIDS is the emergence of viral variants that exhibit drug resistance. The sequences of…”
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Hematopoietic cytokines: Similarities and differences in the structures, with implications for receptor binding by Wlodawer, Alexander, Pavlovsky, Alexander, Gustchina, Alla

“…Crystal and NMR structures of helical cytokines–interleukin‐4 (IL‐4), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), and interleukin‐2 (IL‐2)–have…”
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Structure of equine infectious anemia virus proteinase complexed with an inhibitor by Gustchina, Alla, Kervinen, Jukka, Powell, David J., Zdanov, Alexander, Kay, John, Wlodawer, Alexander

“…Equine infectious anemia virus (EIAV), the causative agent of infectious anemia in horses, is a member of the lentiviral family. The virus‐encoded proteinase…”
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Structural insights of plasmepsin X from Plasmodium falciparum uncovering a novel inactivation mechanism of zymogen by Deshmukh, A., Kesari, P., Pahelkar, N., Suryawanshi, A., Rathore, I., Mishra, V., Dupuis, J., Xiao, H., Gustchina, A., Abendroth, J., Labaied, M., Yada, R., Wlodawer, A., Edwards, T., Lorimer, D., Bhaumik, P.

“…Abstract only…”
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