Search Results - "Gustafsson, Björn I."

Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa by Brenna, Øystein, Furnes, Marianne W., Munkvold, Bjørn, Kidd, Mark, Sandvik, Arne K., Gustafsson, Björn I.

“…Guanylin ( GUCA2A / Guca2a /GN) and uroguanylin ( GUCA2B / Guca2b /UGN) are expressed in the gastrointestinal tract and have been implicated in ion and fluid…”
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Neuroendocrine tumors of the diffuse neuroendocrine system by Gustafsson, Björn I, Kidd, Mark, Modlin, Irvin M

“…PURPOSE OF REVIEWNeuroendocrine tumors (previously referred to as carcinoids) are ill-understood, enigmatic malignancies that, although slow-growing compared…”
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Long-term serotonin administration induces heart valve disease in rats by GUSTAFSSON, Björn I, TØMMERAS, Karin, NORDRUM, Ivar, LOENNECHEN, Jan P, BRUNSVIK, Anders, SOLLIGARD, Erik, FOSSMARK, Reidar, BAKKE, Ingunn, SYVERSEN, Unni, WALDUM, Helge

“…The purpose of this study was to investigate whether rats dosed with serotonin develop changes similar to those seen in human carcinoid heart disease. Ten…”
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Systemic Leptin Administration in Supraphysiological Doses Maintains Bone Mineral Density and Mechanical Strength Despite Significant Weight Loss by Stunes, Astrid K, Westbroek, Irene, Gordeladze, Jan O, Gustafsson, Björn I, Reseland, Janne E, Syversen, Unni

“…The effects of leptin on bone are controversial. Although in vitro studies have shown that leptin stimulates osteoblast differentiation and mineralization and…”
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The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats by Stunes, Astrid K, Westbroek, Irene, Gustafsson, Björn I, Fossmark, Reidar, Waarsing, Jan H, Eriksen, Erik F, Petzold, Christiane, Reseland, Janne E, Syversen, Unni

“…Activation of peroxisome proliferator-activated receptor (PPAR)gamma is associated with bone loss and increased fracture risk, while PPARalpha activation seems…”
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Principal Component Analysis, Hierarchical Clustering, and Decision Tree Assessment of Plasma mRNA and Hormone Levels as an Early Detection Strategy for Small Intestinal Neuroendocrine (Carcinoid) Tumors by Modlin, Irvin M., Gustafsson, Björn I., Drozdov, Ignat, Nadler, Boaz, Pfragner, Roswitha, Kidd, Mark

“…Incidence of neuroendocrine tumors (NETs) is increasing (approximately 6%/year), but clinical presentation is nonspecific, resulting in delays in diagnosis…”
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Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone by Syversen, Unni, Stunes, Astrid K, Gustafsson, Björn I, Obrant, Karl J, Nordsletten, Lars, Berge, Rolf, Thommesen, Liv, Reseland, Janne E

“…Abstract Background All the peroxisome proliferator activated receptors (PPARs) are found to be expressed in bone cells. The PPARγ agonist rosiglitazone has…”
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The Epidemiology of Gastroenteropancreatic Neuroendocrine Tumors by Lawrence, Ben, MBChB, MSc, Gustafsson, Bjorn I., MD, PhD, Chan, Anthony, MD, Svejda, Bernhard, MD, Kidd, Mark, PhD, Modlin, Irvin M., MD, PhD, DSc, FRCS(Eng & Ed)

“…In this article, updated analyses of the National Cancer Institute Surveillance, Epidemiology and End Results (SEER) registry (1973–2007) are presented and…”
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Long-term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats by Gustafsson, Björn I., Westbroek, Irene, Waarsing, Jan H., Waldum, Helge, Solligård, Erik, Brunsvik, Anders, Dimmen, Sigbjørn, van Leeuwen, Johannes P.T.M., Weinans, Harrie, Syversen, Unni

“…New evidence suggests a control of bone mass by the central nervous system. We have previously shown that functional serotonin receptors are present in bone…”
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Chromogranin A—Biological Function and Clinical Utility in Neuro Endocrine Tumor Disease by Modlin, Irvin M., Gustafsson, Bjorn I., Moss, Steven F., Pavel, Marianne, Tsolakis, Apostolos V., Kidd, Mark

“…Background Neuroendocrine tumors (NETs) are a form of cancer that differ from other neoplasia in that they synthesize, store, and secrete peptides, e.g.,…”
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Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD by Brenna, Øystein, Furnes, Marianne W, Drozdov, Ignat, van Beelen Granlund, Atle, Flatberg, Arnar, Sandvik, Arne K, Zwiggelaar, Rosalie T M, Mårvik, Ronald, Nordrum, Ivar S, Kidd, Mark, Gustafsson, Björn I

“…Rectal instillation of trinitrobenzene sulphonic acid (TNBS) in ethanol is an established model for inflammatory bowel disease (IBD). We aimed to 1) set up a…”
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Bronchopulmonary neuroendocrine tumors by Gustafsson, Bjorn I., Kidd, Mark, Chan, Anthony, Malfertheiner, Max V., Modlin, Irvin M.

“…Bronchopulmonary neuroendocrine tumors (BP‐NETs) comprise ≈20% of all lung cancers and represent a spectrum of tumors arising from neuroendocrine cells of the…”
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Serotonin and fluoxetine receptors are expressed in enamel organs and LS8 cells and modulate gene expression in LS8 cells by Riksen, Elisabeth A., Stunes, Astrid K., Kalvik, Anne, Gustafsson, Björn I., Snead, Malcolm L., Syversen, Unni, Lyngstadaas, Ståle P., Reseland, Janne E.

“…Riksen EA, Stunes AK, Kalvik A, Gustafsson BI, Snead ML, Syversen U, Lyngstadaas SP, Reseland JE. Serotonin and fluoxetine receptors are expressed in enamel…”
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Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis by Granlund, Atle van Beelen, Flatberg, Arnar, Østvik, Ann E, Drozdov, Ignat, Gustafsson, Bjørn I, Kidd, Mark, Beisvag, Vidar, Torp, Sverre H, Waldum, Helge L, Martinsen, Tom Christian, Damås, Jan Kristian, Espevik, Terje, Sandvik, Arne K

“…In inflammatory bowel disease (IBD), genetic susceptibility together with environmental factors disturbs gut homeostasis producing chronic inflammation. The…”
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Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants by Kidd, Mark, Modlin, Irvin M, Gustafsson, Bjorn I, Drozdov, Ignat, Hauso, Oyvind, Pfragner, Roswitha

“…Mechanisms by which gut luminal content regulates secretion and motility are ill understood. We evaluated whether neuroendocrine enterochromaffin (EC) cells…”
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The Clinical Relevance of Chromogranin A as a Biomarker for Gastroenteropancreatic Neuroendocrine Tumors by Lawrence, Ben, MBChB, MSc, Gustafsson, Bjorn I., MD, PhD, Kidd, Mark, PhD, Pavel, Marianne, MD, Svejda, Bernhard, MD, Modlin, Irvin M., MD, PhD, DSc, FRCS(Eng & Ed)

“…Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of…”
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The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease by Brenna, Øystein, Bruland, Torunn, Furnes, Marianne W., Granlund, Atle van Beelen, Drozdov, Ignat, Emgård, Johanna, Brønstad, Gunnar, Kidd, Mark, Sandvik, Arne K., Gustafsson, Björn I.

“…Objective. Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in gastrointestinal fluid and electrolyte balance, preservation of…”
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REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation by van Beelen Granlund, Atle, Østvik, Ann Elisabet, Brenna, Øystein, Torp, Sverre H., Gustafsson, Bjørn I., Sandvik, Arne Kristian

“…The regenerating islet-derived (REG) gene family encodes a group of proteins highly expressed in several human pathologies, many of which are associated with…”
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Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease by Ostvik, Ann E, Granlund, Atle vB, Gustafsson, Bjørn I, Torp, Sverre H, Espevik, Terje, Mollnes, Tom E, Damås, Jan K, Sandvik, Arne K

“…Recent studies link Toll-like receptor 3 (TLR3) to the pathogenesis of inflammatory bowel disease (IBD). Screening TLR3-agonist response in an intestinal…”
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Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift by Waldum, Helge L., Öberg, Kjell, Sørdal, Øystein F., Sandvik, Arne K., Gustafsson, Bjørn I., Mjønes, Patricia, Fossmark, Reidar

“…Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their…”
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