Search Results - "Gustafson, Claire E"

Lymphocyte generation and population homeostasis throughout life by Yanes, Rolando E, Gustafson, Claire E, Weyand, Cornelia M, Goronzy, Jörg J

“…Abstract Immune aging is a multi-faceted process that manifests as reduced competence to fight infections and malignant cells, as well as diminished tissue…”
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Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells by Hu, Bin, Jadhav, Rohit R, Gustafson, Claire E, Le Saux, Sabine, Ye, Zhongde, Li, Xuanying, Tian, Lu, Weyand, Cornelia M, Goronzy, Jörg J

“…Healthy immune aging is in part determined by how well the sizes of naïve T cell compartments are being maintained with advancing age. Throughout adult life,…”
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T follicular helper cell development and functionality in immune ageing by Gustafson, Claire E, Weyand, Cornelia M, Goronzy, Jörg J

“…By 2050, there will be over 1.6 billion adults aged 65 years and older, making age-related diseases and conditions a growing public health concern. One of the…”
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Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency by Kim, Chulwoo, Jadhav, Rohit R., Gustafson, Claire E., Smithey, Megan J., Hirsch, Alec J., Uhrlaub, Jennifer L., Hildebrand, William H., Nikolich-Žugich, Janko, Weyand, Cornelia M., Goronzy, Jörg J.

“…Generation of protective immunity to infections and vaccinations declines with age. Studies in healthy individuals have implicated reduced miR-181a expression…”
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Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant by Higdon, Lauren E, Gustafson, Claire E, Ji, Xuhuai, Sahoo, Malaya K, Pinsky, Benjamin A, Margulies, Kenneth B, Maecker, Holden T, Goronzy, Jorg, Maltzman, Jonathan S

“…Immune function is altered with increasing age. Infection with cytomegalovirus (CMV) accelerates age-related immunological changes resulting in expanded…”
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Corrigendum: Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells by Hu, Bin, Jadhav, Rohit R, Gustafson, Claire E, Le Saux, Sabine, Ye, Zhongde, Li, Xuanying, Tian, Lu, Weyand, Cornelia M, Goronzy, Jörg J

“…[This corrects the article DOI: 10.3389/fimmu.2020.585168.]…”
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Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging by Gustafson, Claire E, Qi, Qian, Hutter-Saunders, Jessica, Gupta, Sheena, Jadhav, Rohit, Newell, Evan, Maecker, Holden, Weyand, Cornelia M, Goronzy, Jörg J

“…Aging is associated with an increased susceptibility to infection and a failure to control latent viruses thought to be driven, at least in part, by…”
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Influence of immune aging on vaccine responses by Gustafson, Claire E., Kim, Chulwoo, Weyand, Cornelia M., Goronzy, Jörg J.

“…Impaired vaccine responses in older individuals are associated with alterations in both the quantity and quality of the T-cell compartment with age. As…”
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The influence of three-dimensional structure on naïve T cell homeostasis and aging by Lambert, Simon, Cao, Wenqiang, Zhang, Huimin, Colville, Alex, Liu, Jie-Yu, Weyand, Cornelia M, Goronzy, Jorg J, Gustafson, Claire E

“…A breakdown in cellular homeostasis is thought to drive naïve T cell aging, however the link between naïve T cell homeostasis and aging in humans is poorly…”
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Mechanism of Mitochondrial Transcription Factor A Attenuation of CpG-Induced Antibody Production by Malarkey, Christopher S, Gustafson, Claire E, Saifee, Jessica F, Torres, Raul M, Churchill, Mair E A, Janoff, Edward N

“…Mitochondrial transcription factor A (TFAM) had previously been shown to act as a damage associated molecular pattern with the ability to enhance CpG-A…”
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Remodeled structure and reduced contractile responsiveness of ocular ciliary artery in spontaneously hypertensive rats by Dong, Ya-Ru, Gustafson, Claire E, Wang, Jun, Cui, Ji-Zhe, Yoshitomi, Takeshi

“…To investigate the alterations in both structure and contractile responsiveness of ocular ciliary artery (OCA) in spontaneously hypertensive rat (SHR). In this…”
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Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation by Hu, Bin, Li, Guangjin, Ye, Zhongde, Gustafson, Claire E., Tian, Lu, Weyand, Cornelia M., Goronzy, Jörg J.

“…With reduced thymic activity, the population of naïve T cells in humans is maintained by homeostatic proliferation throughout adult life. In young adults,…”
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Functional pathways regulated by microRNA networks in CD8 T‐cell aging by Gustafson, Claire E., Cavanagh, Mary M., Jin, Jun, Weyand, Cornelia M., Goronzy, Jörg J.

“…One of the most prominent immunological changes during human aging is the alteration in CD8 T‐cell subset distribution, predominated by a loss of naïve CD8 T…”
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Histone deficiency and accelerated replication stress in T cell aging by Kim, Chulwoo, Jin, Jun, Ye, Zhongde, Jadhav, Rohit R, Gustafson, Claire E, Hu, Bin, Cao, Wenqiang, Tian, Lu, Weyand, Cornelia M, Goronzy, Jörg J

“…With increasing age, individuals are more vulnerable to viral infections such as with influenza or the SARS-CoV-2 virus. One age-associated defect in human T…”
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Understanding T cell aging to improve anti-viral immunity by Zhang, Huimin, Weyand, Cornelia M, Goronzy, Jörg J, Gustafson, Claire E

“…T cells are a critical component of the immune system and required for protection against viral and bacterial infections. However, the capacity of these cells…”
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Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment by Thomson, Zachary, He, Ziyuan, Swanson, Elliott, Henderson, Katherine, Phalen, Cole, Zaim, Samir Rachid, Pebworth, Mark-Phillip, Okada, Lauren Y., Heubeck, Alexander T., Roll, Charles R., Hernandez, Veronica, Weiss, Morgan, Genge, Palak C., Reading, Julian, Giles, Josephine R., Manne, Sasikanth, Dougherty, Jeanette, Jasen, C. J., Greenplate, Allison R., Becker, Lynne A., Graybuck, Lucas T., Vasaikar, Suhas V., Szeto, Gregory L., Savage, Adam K., Speake, Cate, Buckner, Jane H., Li, Xiao-jun, Bumol, Thomas F., Wherry, E.John, Torgerson, Troy R., Vella, Laura A., Henrickson, Sarah E., Skene, Peter J., Gustafson, Claire E.

“…Age-associated changes in the T cell compartment are well described. However, limitations of current single-modal or bimodal single-cell assays, including flow…”
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Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment by Thomson, Zachary, He, Ziyuan, Swanson, Elliott, Henderson, Katherine, Phalen, Cole, Zaim, Samir Rachid, Pebworth, Mark-Phillip, Okada, Lauren Y., Heubeck, Alexander T., Roll, Charles R., Hernandez, Veronica, Weiss, Morgan, Genge, Palak C., Reading, Julian, Giles, Josephine R., Manne, Sasikanth, Dougherty, Jeanette, Jasen, C. J., Greenplate, Allison R., Becker, Lynne A., Graybuck, Lucas T., Vasaikar, Suhas V., Szeto, Gregory L., Savage, Adam K., Speake, Cate, Buckner, Jane H., Li, Xiao-jun, Bumol, Thomas F., Wherry, E.John, Torgerson, Troy R., Vella, Laura A., Henrickson, Sarah E., Skene, Peter J., Gustafson, Claire E.

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Immune cell repertoires in breast cancer patients after adjuvant chemotherapy by Gustafson, Claire E, Jadhav, Rohit, Cao, Wenqiang, Qi, Qian, Pegram, Mark, Tian, Lu, Weyand, Cornelia M, Goronzy, Jorg J

“…Adjuvant chemotherapy in breast cancer patients causes immune cell depletion at an age when the regenerative capacity is compromised. Successful regeneration…”
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It's good to have Gremlins in the zone by Gustafson, Claire E, Maltzman, Jonathan S

“…A unique subset of Gremlin1-expressing fibroblastic reticular cells mediate cDC homeostasis and functionality within lymph nodes…”
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Thromboxane Receptor Signaling Is Required for Fibronectin-induced Matrix Metalloproteinase 9 Production by Human and Murine Macrophages and Is Attenuated by the Arhgef1 Molecule by Hartney, John M., Gustafson, Claire E., Bowler, Russell P., Pelanda, Roberta, Torres, Raul M.

“…During an inflammatory response, resident and newly recruited tissue macrophages adhere to extracellular matrix and cell-bound integrin ligands. This…”
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