Search Results - "Gussekloo, Jacobijn"
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Effects of a clinical medication review focused on personal goals, quality of life, and health problems in older persons with polypharmacy: A randomised controlled trial (DREAMeR-study)
Published in PLoS medicine (08-05-2019)“…Clinical medication reviews (CMRs) are increasingly performed in older persons with multimorbidity and polypharmacy to reduce drug-related problems (DRPs)…”
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Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism
Published in The New England journal of medicine (29-06-2017)“…A double-blind, randomized, placebo-controlled, parallel-group trial aimed to determine whether levothyroxine provided clinical benefits in older persons with…”
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Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies
Published in The journal of clinical endocrinology and metabolism (01-12-2016)“…Context: Although both overt hyper- and hypothyroidism are known to lead to cognitive impairment, data on the association between subclinical thyroid…”
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Meta-analysis : Subclinical Thyroid Dysfunction and the Risk for Coronary Heart Disease and Mortality
Published in Annals of internal medicine (03-06-2008)“…Data on the association between subclinical thyroid dysfunction and coronary heart disease (CHD) and mortality are conflicting. To summarize prospective…”
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Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation
Published in Circulation (New York, N.Y.) (28-11-2017)“…Atrial fibrillation (AF) is a highly prevalent disorder leading to heart failure, stroke, and death. Enhanced understanding of modifiable risk factors may…”
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Potentially inappropriate medication and attitudes of older adults towards deprescribing
Published in PloS one (26-10-2020)“…Multimorbidity and polypharmacy are current challenges when caring for the older population. Both have led to an increase of potentially inappropriate…”
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Professional identity formation of medical students in relation to older persons’ healthcare: exploring the views of older persons living in the Netherlands – a qualitative study
Published in BMJ open (25-09-2024)“…ObjectivesGiven the growing population of older persons, medical students need to develop an appropriate professional identity to comply with older persons’…”
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What do older adults with multimorbidity and polypharmacy think about deprescribing? The LESS study - a primary care-based survey
Published in BMC geriatrics (31-10-2020)“…Multimorbidity and polypharmacy are very common in older adults in primary care. Ideally, general practitioners (GPs), should regularly review medication lists…”
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Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis
Published in The journal of clinical endocrinology and metabolism (01-06-2015)“…Objective: The objective was to determine the risk of stroke associated with subclinical hypothyroidism. Data Sources and Study Selection: Published…”
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Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies
Published in PloS one (07-01-2022)“…Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death…”
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Subclinical Thyroid Dysfunction and the Risk of Heart Failure in Older Persons at High Cardiovascular Risk
Published in The journal of clinical endocrinology and metabolism (01-03-2012)“…Context: Subclinical thyroid dysfunction is common in older people. However, its clinical importance is uncertain. Objective: Our objective was to determine…”
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Temporal Relationship Between Cognitive and Physical Performance in Middle-Aged to Oldest Old People
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-05-2017)“…Cognitive and physical impairment frequently co-occur in older people. The aim of this study was to assess the temporal order of these age-related changes in…”
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Systolic Blood Pressure and Cognitive Decline in Older Adults With Hypertension
Published in Annals of family medicine (01-03-2019)“…Abstract Purpose Hypertension trials often exclude patients with complex health problems and lack generalizability. We aimed to determine if systolic blood…”
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The effect of a telephone follow-up call for older patients, discharged home from the emergency department on health-related outcomes: a systematic review of controlled studies
Published in International journal of emergency medicine (18-02-2021)“…Background Older patients discharged from the emergency department (ED) are at increased risk for adverse outcomes. Transitional care programs offer close…”
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Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis
Published in The journal of clinical endocrinology and metabolism (01-11-2016)“…Context: The currently applied reference ranges for thyroid function are under debate. Despite evidence that thyroid function within the reference range is…”
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High Blood Pressure and Resilience to Physical and Cognitive Decline in the Oldest Old: The Leiden 85-Plus Study
Published in Journal of the American Geriatrics Society (JAGS) (01-11-2012)“…Objectives To evaluate the association between various blood pressure (BP) measures at age 85 and future decline in physical and cognitive function the oldest…”
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Experiences with and attitudes towards geriatric screening among older emergency department patients: a qualitative study
Published in BMC geriatrics (20-03-2021)“…The patient perspective on the use of screening for high risks of adverse health outcomes in Emergency Department (ED) care is underexposed, although it is an…”
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Clinical determinants of low handgrip strength and its decline in the oldest old: the Leiden 85-plus Study
Published in Aging clinical and experimental research (01-05-2021)“…Background Age-related decline in muscle strength, dynapenia, is linked to serious adverse health outcomes. Evidence on the determinants of muscle strength…”
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Frequencies and reasons for unplanned emergency department return visits by older adults: a cohort study
Published in BMC geriatrics (18-05-2023)“…As unplanned Emergency Department (ED) return visits (URVs) are associated with adverse health outcomes in older adults, many EDs have initiated post-discharge…”
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Effects of discontinuation of levothyroxine treatment in older adults: protocol for a self-controlled trial
Published in BMJ open (25-04-2023)“…BackgroundMany older persons use the thyroid hormone levothyroxine which is often continued for life. Scientifically, there is much uncertainty whether simple…”
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