Search Results - "Guss, J"

Using controlled disorder to probe the interplay between charge order and superconductivity in NbSe2 by Cho, Kyuil, Kończykowski, M., Teknowijoyo, S., Tanatar, M. A., Guss, J., Gartin, P. B., Wilde, J. M., Kreyssig, A., McQueeney, R. J., Goldman, A. I., Mishra, V., Hirschfeld, P. J., Prozorov, R.

“…The interplay between superconductivity and charge-density wave (CDW) in 2 H -NbSe 2 is not fully understood despite decades of study. Artificially introduced…”
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Cyclic peptides can engage a single binding pocket through highly divergent modes by Patel, Karishma, Walport, Louise J., Walshe, James L., Solomon, Paul D., Low, Jason K. K., Tran, Daniel H., Mouradian, Kevork S., Silva, Ana P. G., Wilkinson-White, Lorna, Norman, Alexander, Franck, Charlotte, Matthews, Jacqueline M., Guss, J. Mitchell, Payne, Richard J., Passioura, Toby, Suga, Hiroaki, Mackay, Joel P.

“…Cyclic peptide library screening technologies show immense promise for identifying drug leads and chemical probes for challenging targets. However, the…”
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2017 publication guidelines for structural modelling of small‐angle scattering data from biomolecules in solution: an update by Trewhella, Jill, Duff, Anthony P., Durand, Dominique, Gabel, Frank, Guss, J. Mitchell, Hendrickson, Wayne A., Hura, Greg L., Jacques, David A., Kirby, Nigel M., Kwan, Ann H., Pérez, Javier, Pollack, Lois, Ryan, Timothy M., Sali, Andrej, Schneidman-Duhovny, Dina, Schwede, Torsten, Svergun, Dmitri I., Sugiyama, Masaaki, Tainer, John A., Vachette, Patrice, Westbrook, John, Whitten, Andrew E.

“…In 2012, preliminary guidelines were published addressing sample quality, data acquisition and reduction, presentation of scattering data and validation, and…”
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A heme‐binding protein produced by Haemophilus haemolyticus inhibits non‐typeable Haemophilus influenzae by Latham, Roger D., Torrado, Mario, Atto, Brianna, Walshe, James L., Wilson, Richard, Guss, J. Mitchell, Mackay, Joel P., Tristram, Stephen, Gell, David A.

“…Commensal bacteria serve as an important line of defense against colonisation by opportunisitic pathogens, but the underlying molecular mechanisms remain…”
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A round‐robin approach provides a detailed assessment of biomolecular small‐angle scattering data reproducibility and yields consensus curves for benchmarking by Trewhella, Jill, Vachette, Patrice, Bierma, Jan, Blanchet, Clement, Brookes, Emre, Chakravarthy, Srinivas, Chatzimagas, Leonie, Cleveland, Thomas E., Cowieson, Nathan, Crossett, Ben, Duff, Anthony P., Franke, Daniel, Gabel, Frank, Gillilan, Richard E., Graewert, Melissa, Grishaev, Alexander, Guss, J. Mitchell, Hammel, Michal, Hopkins, Jesse, Huang, Qingqui, Hub, Jochen S., Hura, Greg L., Irving, Thomas C., Jeffries, Cy Michael, Jeong, Cheol, Kirby, Nigel, Krueger, Susan, Martel, Anne, Matsui, Tsutomu, Li, Na, Pérez, Javier, Porcar, Lionel, Prangé, Thierry, Rajkovic, Ivan, Rocco, Mattia, Rosenberg, Daniel J., Ryan, Timothy M., Seifert, Soenke, Sekiguchi, Hiroshi, Svergun, Dmitri, Teixeira, Susana, Thureau, Aurelien, Weiss, Thomas M., Whitten, Andrew E., Wood, Kathleen, Zuo, Xiaobing

“…Through an expansive international effort that involved data collection on 12 small‐angle X‐ray scattering (SAXS) and four small‐angle neutron scattering…”
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Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development by Guss, Ellen J, Akbergenova, Yulia, Cunningham, Karen L, Littleton, J Troy

“…Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and…”
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The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis by Guss, J.D., Ziemian, S.N., Luna, M., Sandoval, T.N., Holyoak, D.T., Guisado, G.G., Roubert, S., Callahan, R.L., Brito, I.L., van der Meulen, M.C.H., Goldring, S.R., Hernandez, C.J.

“…Metabolic syndrome is characterized by obesity, hyperglycemia, hypertension, insulin resistance, and dyslipidemia. Metabolic syndrome is associated with…”
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GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA by Wilkinson‐White, Lorna, Lester, Krystal L., Ripin, Nina, Jacques, David A., Mitchell Guss, J., Matthews, Jacqueline M.

“…The transcription factor GATA1 helps regulate the expression of thousands of genes involved in blood development, by binding to single or double GATA sites on…”
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The cation-dependent G-proteins: In a class of their own by Ash, Miriam-Rose, Maher, Megan J., Mitchell Guss, J., Jormakka, Mika

“…► Sodium or potassium ions accelerate GTP hydrolysis by the cation-dependent G-proteins. ► Most cation-dependent GTPases select for potassium at their active…”
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The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia by Nehme, Ralda, Pietiläinen, Olli, Artomov, Mykyta, Tegtmeyer, Matthew, Valakh, Vera, Lehtonen, Leevi, Bell, Christina, Singh, Tarjinder, Trehan, Aditi, Sherwood, John, Manning, Danielle, Peirent, Emily, Malik, Rhea, Guss, Ellen J., Hawes, Derek, Beccard, Amanda, Bara, Anne M., Hazelbaker, Dane Z., Zuccaro, Emanuela, Genovese, Giulio, Loboda, Alexander A., Neumann, Anna, Lilliehook, Christina, Kuismin, Outi, Hamalainen, Eija, Kurki, Mitja, Hultman, Christina M., Kähler, Anna K., Paulo, Joao A., Ganna, Andrea, Madison, Jon, Cohen, Bruce, McPhie, Donna, Adolfsson, Rolf, Perlis, Roy, Dolmetsch, Ricardo, Farhi, Samouil, McCarroll, Steven, Hyman, Steven, Neale, Ben, Barrett, Lindy E., Harper, Wade, Palotie, Aarno, Daly, Mark, Eggan, Kevin

“…It is unclear how the 22q11.2 deletion predisposes to psychiatric disease. To study this, we generated induced pluripotent stem cells from deletion carriers…”
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Clinically Linked Mutations in the Central Domains of Cardiac Myosin-Binding Protein C with Distinct Phenotypes Show Differential Structural Effects by Nadvi, Naveed Ahmed, Michie, Katharine A., Kwan, Ann H., Guss, J. Mitchell, Trewhella, Jill

“…The structural effects of three missense mutations clinically linked to hypertrophic cardiomyopathy (HCM) and located in the central domains of cardiac…”
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Mutation in a flexible linker modulates binding affinity for modular complexes by Stokes, Philippa H., Robertson, Neil O., Silva, Ana P. G., Estephan, Tanya, Trewhella, Jill, Guss, J. Mitchell, Matthews, Jacqueline M.

“…Tandem beta zippers are modular complexes formed between repeated linear motifs and tandemly arrayed domains of partner proteins in which β‐strands form upon…”
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Structure of the Hemoglobin-IsdH Complex Reveals the Molecular Basis of Iron Capture by Staphylococcus aureus by Dickson, Claire F., Kumar, Kaavya Krishna, Jacques, David A., Malmirchegini, G. Reza, Spirig, Thomas, Mackay, Joel P., Clubb, Robert T., Guss, J. Mitchell, Gell, David A.

“…Staphylococcus aureus causes life-threatening disease in humans. The S. aureus surface protein iron-regulated surface determinant H (IsdH) binds to mammalian…”
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The science is in the data by Helliwell, John R, McMahon, Brian, Guss, J Mitchell, Kroon-Batenburg, Loes M J

“…Understanding published research results should be through one's own eyes and include the opportunity to work with raw diffraction data to check the various…”
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Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution by Jacques, David A., Guss, J. Mitchell, Svergun, Dmitri I., Trewhella, Jill

“…Small‐angle scattering is becoming a mainstream technique for structural molecular biology. As such, it is important to establish guidelines for publication…”
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Hans Charles Freeman (1929–2008): A scientific journey from dipole moments to protein crystallography by Guss, J. Mitchell

“…Hans Freeman began his scientific career as an undergraduate student focusing on physical organic chemistry. During the studies for his PhD he had the…”
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Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells by Guss, Ellen J., Sathe, Laila, Dai, Alexander, Derebenskiy, Tim, Vega, Ana Rodriguez, Eggan, Kevin, Wells, Michael F.

“…Human pluripotent stem cell-derived neural progenitor cells (NPCs) are an essential tool for the study of brain development and developmental disorders such as…”
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Structure and Inhibition of Human Diamine Oxidase by McGrath, Aaron P, Hilmer, Kimberly M, Collyer, Charles A, Shepard, Eric M, Elmore, Bradley O, Brown, Doreen E, Dooley, David M, Guss, J. Mitchell

“…Humans have three functioning genes that encode copper-containing amine oxidases. The product of the AOC1 gene is a so-called diamine oxidase (hDAO), named for…”
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Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH by Krishna Kumar, Kaavya, Jacques, David A., Pishchany, Gleb, Caradoc-Davies, Tom, Spirig, Thomas, Malmirchegini, G. Reza, Langley, David B., Dickson, Claire F., Mackay, Joel P., Clubb, Robert T., Skaar, Eric P., Guss, J. Mitchell, Gell, David A.

“…Pathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin (Hb) represents the largest reservoir of iron, and pathogens express…”
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The initiation of GTP hydrolysis by the G-domain of FeoB: insights from a transition-state complex structure by Ash, Miriam-Rose, Maher, Megan J, Guss, J Mitchell, Jormakka, Mika

“…The polytopic membrane protein FeoB is a ferrous iron transporter in prokaryotes. The protein contains a potassium-activated GTPase domain that is essential in…”
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