Search Results - "Gusovsky, F."

Dirofilariasis mouse models for heartworm preclinical research by Marriott, A E, Dagley, J L, Hegde, S, Steven, A, Fricks, C, DiCosty, U, Mansour, A, Campbell, E J, Wilson, C M, Gusovsky, F, Ward, S A, Hong, W D, O'Neill, P, Moorhead, A, McCall, S, McCall, J W, Taylor, M J, Turner, J D

“…Dirofilariasis, including heartworm disease, is a major emergent veterinary parasitic infection and a human zoonosis. Currently, experimental infections of…”
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Novel strategies for targeting innate immune responses to influenza by Shirey, K A, Lai, W, Patel, M C, Pletneva, L M, Pang, C, Kurt-Jones, E, Lipsky, M, Roger, T, Calandra, T, Tracey, K J, Al-Abed, Y, Bowie, A G, Fasano, A, Dinarello, C A, Gusovsky, F, Blanco, J C G, Vogel, S N

“…We previously reported that TLR4 −/− mice are refractory to mouse-adapted A/PR/8/34 (PR8) influenza-induced lethality and that therapeutic administration of…”
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A novel antagonist of the prostaglandin E 2 EP 4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models by Chen, Q, Muramoto, K, Masaaki, N, Ding, Y, Yang, H, Mackey, M, Li, W, Inoue, Y, Ackermann, K, Shirota, H, Matsumoto, I, Spyvee, M, Schiller, S, Sumida, T, Gusovsky, F, Lamphier, M

“…Background and purpose:  Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17…”
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Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead by Du, H., Matsushima, T., Spyvee, M., Goto, M., Shirota, H., Gusovsky, F., Chiba, K., Kotake, M., Yoneda, N., Eguchi, Y., DiPietro, L., Harmange, J.-C., Gilbert, S., Li, X.-Y., Davis, H., Jiang, Y., Zhang, Z., Pelletier, R., Wong, N., Sakurai, H., Yang, H., Ito-Igarashi, H., Kimura, A., Kuboi, Y., Mizui, Y., Tanaka, I., Ikemori-Kawada, M., Kawakami, Y., Inoue, A., Kawai, T., Kishi, Y., Wang, Y.

“…With bioactivity-guided phenotype screenings, a potent anti-inflammatory compound f152A1 has been isolated, characterized and identified as the known natural…”
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A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models by Chen, Q, Muramoto, K, Masaaki, N, Ding, Y, Yang, H, Mackey, M, Li, W, Inoue, Y, Ackermann, K, Shirota, H, Matsumoto, I, Spyvee, M, Schiller, S, Sumida, T, Gusovsky, F, Lamphier, M

“…Background and purpose:  Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17…”
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Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma. An alternative mechanism for cholinergic-induced phosphoinositide breakdown by GUSOVSKY, F, LUEDERS, J. E, KOHN, E. C, FELDER, C. C

“…In Chinese hamster ovary cells transfected with m5 muscarinic receptors, carbachol stimulates both calcium influx and calcium release from intracellular…”
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Measurement of second messengers in signal transduction: cAMP and inositol phosphates by Gusovsky, F

“…cAMP acts as an intracellular mediator of hormone action and the importance of accurate quantitative determination of cAMP levels in cells and tissues is…”
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Prostaglandin receptors in NIH 3T3 cells: coupling of one receptor to adenylate cyclase and of a second receptor to phospholipase C by Gusovsky, F

“…In intact NIH 3T3 murine fibroblasts, prostaglandins (PGs) F2 alpha and E2 induce dose-dependent stimulation of inositol monophosphate generation. PGF2 alpha…”
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Frog Secretions and Hunting Magic in the Upper Amazon: Identification of a Peptide that Interacts with an Adenosine Receptor by Daly, John W., Caceres, Janet, Moni, Roger W., Gusovsky, Fabian, Moos, Malcolm, Seamon, Kenneth B., Milton, Katharine, Myers, Charles W.

“…A frog used for "hunting magic" by several groups of Panoan-speaking Indians in the borderline between Brazil and Peru is identified as Phyllomedusa bicolor…”
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Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation by Gusovsky, F, Gutkind, J S

“…Activation of protein kinase C (PKC) in intact cells can induce significant changes, either facilitatory or inhibitory, in cyclic AMP accumulation elicited…”
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Maitotoxin effects are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry by Soergel, D G, Yasumoto, T, Daly, J W, Gusovsky, F

“…The dinoflagellate toxin maitotoxin (MTX) elicited a sustained increase of [Ca2+]i in C6 glioma cells. This response was inhibited by SK&F 96365, a blocker of…”
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Regulation of Phosphatidylinositol Turnover in Brain Synaptoneurosomes: Stimulatory Effects of Agents That Enhance Influx of Sodium Ions by Gusovsky, Fabian, Hollingsworth, Elizabeth B., Daly, John W.

“…Norepinephrine and carbamoylcholine stimulate accumulation of [3H]inositol phosphates from [3H]inositol-labeled guinea pig cerebral cortical synaptoneurosomes…”
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Coupling of the C5a receptor to Gi in U-937 cells and in cells transfected with C5a receptor cDNA by Vanek, M, Hawkins, L D, Gusovsky, F

“…The signaling properties of the receptor for the chemoattractant C5a (C5aR) were investigated in differentiated U-937 cells and in NIH/3T3 cells transfected…”
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Tumor-Suppressor Function of Muscarinic Acetylcholine Receptors is Associated with Activation of Receptor-Operated Calcium Influx by Felder, Christian C., MacArthur, Linda, Ma, Alice L., Gusovsky, Fabian, Kohn, Elise C.

“…Several members of the family of guanine nucleotide-binding protein (G protein)-coupled receptors have recently been shown to induce agonist-dependent foci…”
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Formation of inositol phosphates in synaptoneurosomes of guinea pig brain: stimulatory effects of receptor agonists, sodium channel agents and sodium and calcium ionophores by Gusovsky, F, Daly, J W

“…Carbamylcholine, norepinephrine, histamine and glutamate stimulated the formation of [3H]inositol phosphates in [3H]inositol-labelled synaptoneurosomes…”
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Calcium-dependent effects of maitotoxin on phosphoinositide breakdown and on cyclic AMP accumulation in PC12 and NCB-20 cells by Gusovsky, F, Yasumoto, T, Daly, J W

“…The marine dinoflagellate toxin maitotoxin (MTX) stimulates phosphoinositide breakdown in pheochromocytoma PC12 cells and in neuroblastoma hybrid NCB-20 cells…”
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Stimulation of phosphoinositide breakdown in brain synaptoneurosomes by agents that activate sodium influx: antagonism by tetrodotoxin, saxitoxin, and cadmium by Gusovsky, F, McNeal, E T, Daly, J W

“…Agents that increase intracellular concentrations of Na+ stimulate phosphoinositide breakdown in guinea pig cerebral cortical synaptoneurosomes. When combined,…”
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Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1 by Yang, H, Young, D W, Gusovsky, F, Chow, J C

“…Lipopolysaccharide (LPS) stimulates multiple signaling events, including nuclear factor-kappaB (NF-kappaB) activity and the mitogen-activated protein (MAP)…”
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Adenosine-sensitive phosphoinositide turnover in a newly established renal cell line by Arend, L J, Handler, J S, Rhim, J S, Gusovsky, F, Spielman, W S

“…To aid in characterizing adenosine receptors in renal cells, primary cultures of rabbit cortical collecting tubule (RCCT) cells were infected with an…”
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Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist by Mullarkey, Maureen, Rose, Jeffrey R, Bristol, John, Kawata, Tsutomu, Kimura, Akufumi, Kobayashi, Seiichi, Przetak, Melinda, Chow, Jesse, Gusovsky, Fabian, Christ, William J, Rossignol, Daniel P

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