Search Results - "Gusmao, E. G."

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes by Axelsson, A. S., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I., Fex, M., Johnson, J. D., Wollheim, C. B., Derry, J.M.J., Mecham, B., Spégel, P., Mulder, H., Costa, I.G., Zhang, E., Rosengren, A. H.

“…Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not…”
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Mtss1 is a critical epigenetically regulated tumor suppressor in CML by Schemionek, M, Herrmann, O, Reher, M M, Chatain, N, Schubert, C, Costa, I G, Hänzelmann, S, Gusmao, E G, Kintsler, S, Braunschweig, T, Hamilton, A, Helgason, G V, Copland, M, Schwab, A, Müller-Tidow, C, Li, S, Holyoake, T L, Brümmendorf, T H, Koschmieder, S

“…Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be…”
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The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification by Ullius, Andrea, Lüscher-Firzlaff, Juliane, Costa, Ivan G, Walsemann, Gesa, Forst, Alexandra H, Gusmao, Eduardo G, Kapelle, Karsten, Kleine, Henning, Kremmer, Elisabeth, Vervoorts, Jörg, Lüscher, Bernhard

“…The appropriate expression of the roughly 30,000 human genes requires multiple layers of control. The oncoprotein MYC, a transcriptional regulator, contributes…”
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Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations by Gothe, Henrike Johanna, Bouwman, Britta Annika Maria, Gusmao, Eduardo Gade, Piccinno, Rossana, Petrosino, Giuseppe, Sayols, Sergi, Drechsel, Oliver, Minneker, Vera, Josipovic, Natasa, Mizi, Athanasia, Nielsen, Christian Friberg, Wagner, Eva-Maria, Takeda, Shunichi, Sasanuma, Hiroyuki, Hudson, Damien Francis, Kindler, Thomas, Baranello, Laura, Papantonis, Argyris, Crosetto, Nicola, Roukos, Vassilis

“…How spatial chromosome organization influences genome integrity is still poorly understood. Here, we show that DNA double-strand breaks (DSBs) mediated by…”
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization by Zampetidis, Christos P., Galanos, Panagiotis, Angelopoulou, Andriani, Zhu, Yajie, Polyzou, Aikaterini, Karamitros, Timokratis, Kotsinas, Athanassios, Lagopati, Nefeli, Mourkioti, Ioanna, Mirzazadeh, Reza, Polyzos, Alexandros, Garnerone, Silvano, Mizi, Athanasia, Gusmao, Eduardo G., Sofiadis, Konstantinos, Gál, Zita, Larsen, Dorthe H., Pefani, Dafni-Eleftheria, Demaria, Marco, Tsirigos, Aristotelis, Crosetto, Nicola, Maya-Mendoza, Apolinar, Papaspyropoulos, Angelos, Evangelou, Konstantinos, Bartek, Jiri, Papantonis, Argyris, Gorgoulis, Vassilis G.

“…Oncogene-induced senescence (OIS) is an inherent and important tumor suppressor mechanism. However, if not removed timely via immune surveillance, senescent…”
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A Case-Control Study of Non-parametric Approaches for Detecting SNP-SNP Interactions by de Araujo, F. R. B., Gusmao, E. G., Guimaraes, K. S.

“…The massive volume of SNP data available requires the use of adequate computational strategies to properly handle it. Identify the SNP-SNP and SNP-environment…”
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