N-Acetonylnitropyrazolecarboxylic acids in the selective synthesis of N-acetonyl-3-R-5-nitropyrazolyl-1,2,4-oxadiazoles

Alkylation of isomeric methyl nitropyrazolecarboxylates with bromoacetone followed by acid hydrolysis gave new N -acetonylnitropyrazolecarboxylic acids. A selective synthesis of 3-R-5-( N -acetonylnitropyrazolyl)-1,2,4-oxadiazoles based on the reaction of nitropyrazolecarboxylic acid chlorides with...

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Bibliographic Details
Published in:Russian chemical bulletin Vol. 73; no. 5; pp. 1362 - 1373
Main Authors: Khoranyan, T. E., Gushchina, P. K., Suponitsky, K. Yu, Dalinger, I. L.
Format: Journal Article
Language:English
Published: New York Springer US 01-05-2024
Springer Nature B.V
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Summary:Alkylation of isomeric methyl nitropyrazolecarboxylates with bromoacetone followed by acid hydrolysis gave new N -acetonylnitropyrazolecarboxylic acids. A selective synthesis of 3-R-5-( N -acetonylnitropyrazolyl)-1,2,4-oxadiazoles based on the reaction of nitropyrazolecarboxylic acid chlorides with isomeric amidoximes of nitropyrazoles and aminofurazan was developed. The possibility to introduce the second N -acetonyl group into di(nitropyrazolyl)-1,2,4-oxadiazoles was studied.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-024-4254-2