Search Results - "Gushchina, Liubov' V."

Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases by Gushchina, Liubov V., Kwiatkowski, Thomas A., Bhattacharya, Sayak, Weisleder, Noah L.

“…The tripartite motif (TRIM) gene family is a highly conserved group of E3 ubiquitin ligase proteins that can establish substrate specificity for the…”
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Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction by Zhao, Shuting, Xu, Zhaobin, Wang, Hai, Reese, Benjamin E., Gushchina, Liubov V., Jiang, Meng, Agarwal, Pranay, Xu, Jiangsheng, Zhang, Mingjun, Shen, Rulong, Liu, Zhenguo, Weisleder, Noah, He, Xiaoming

“…It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy…”
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Systemic delivery of an AAV9 exon-skipping vector significantly improves or prevents features of Duchenne muscular dystrophy in the Dup2 mouse by Wein, Nicolas, Vetter, Tatyana A., Vulin, Adeline, Simmons, Tabatha R., Frair, Emma C., Bradley, Adrienne J., Gushchina, Liubov V., Almeida, Camila F., Huang, Nianyuan, Lesman, Daniel, Rajakumar, Dhanarajan, Weiss, Robert B., Flanigan, Kevin M.

“…Duchenne muscular dystrophy (DMD) is typically caused by mutations that disrupt the DMD reading frame, but nonsense mutations in the 5′ part of the gene induce…”
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Systemic PPMO-mediated dystrophin expression in the Dup2 mouse model of Duchenne muscular dystrophy by Gushchina, Liubov V., Vetter, Tatyana A., Frair, Emma C., Bradley, Adrienne J., Grounds, Kelly M., Lay, Jacob W., Huang, Nianyuan, Suhaiba, Aisha, Schnell, Frederick J., Hanson, Gunnar, Simmons, Tabatha R., Wein, Nicolas, Flanigan, Kevin M.

“…Duchenne muscular dystrophy (DMD) is a devastating muscle-wasting disease that arises due to the loss of dystrophin expression, leading to progressive loss of…”
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Persistence of exon 2 skipping and dystrophin expression at 18 months after U7snRNA-mediated therapy in the Dup2 mouse model by Gushchina, Liubov V., Bradley, Adrienne J., Vetter, Tatyana A., Lay, Jacob W., Rohan, Natalie L., Frair, Emma C., Wein, Nicolas, Flanigan, Kevin M.

“…Duchenne muscular dystrophy (DMD) is a progressive X-linked disease caused by mutations in the DMD gene that prevent the expression of a functional dystrophin…”
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Absence of Significant Off-Target Splicing Variation with a U7snRNA Vector Targeting DMD Exon 2 Duplications by Wein, Nicolas, Dunn, Diane M, Waldrop, Megan A, Gushchina, Liubov V, Frair, Emma C, Weiss, Robert B, Flanigan, Kevin M

“…Exon skipping therapies for Duchenne muscular dystrophy that restore an open reading frame can be induced by the use of noncoding U7 small nuclear RNA…”
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Lack of Toxicity in Nonhuman Primates Receiving Clinically Relevant Doses of an AAV9.U7snRNA Vector Designed to Induce DMD Exon 2 Skipping by Gushchina, Liubov V, Frair, Emma C, Rohan, Natalie, Bradley, Adrienne J, Simmons, Tabatha R, Chavan, Hemantkumar D, Chou, Hsin-Jung, Eggers, Michelle, Waldrop, Megan A, Wein, Nicolas, Flanigan, Kevin M

“…Therapeutic exon skipping as a treatment for Duchenne muscular dystrophy (DMD) has largely concentrated on the delivery of antisense oligomers to treat…”
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Treatment with Recombinant Human MG53 Protein Increases Membrane Integrity in a Mouse Model of Limb Girdle Muscular Dystrophy 2B by Gushchina, Liubov V., Bhattacharya, Sayak, McElhanon, Kevin E., Choi, Jin Hyuk, Manring, Heather, Beck, Eric X, Alloush, Jenna, Weisleder, Noah

“…Limb girdle muscular dystrophy type 2B (LGMD2B) and other dysferlinopathies are degenerative muscle diseases that result from mutations in the dysferlin gene…”
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miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity by Gaudet, Andrew D., Fonken, Laura K., Gushchina, Liubov V., Aubrecht, Taryn G., Maurya, Santosh K., Periasamy, Muthu, Nelson, Randy J., Popovich, Phillip G.

“…Obesity is a growing epidemic in developed countries. Obese individuals are susceptible to comorbidities, including cardiovascular disease and metabolic…”
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Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking by Bhattacharya, Sayak, McElhanon, Kevin E., Gushchina, Liubov V., Weisleder, Noah

“…Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling…”
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Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner by Gushchina, Liubov V., Yasmeen, Rumana, Ziouzenkova, Ouliana

“…•A 5-fold increase in vitamin A in a high-fat diet (HFA vs. HF diet) does not influence obesity in mice.•HFA vs. HF diet increased concentrations of…”
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Adipocyte reporter assays: Application for identification of anti‐inflammatory and antioxidant properties of mangosteen xanthones by Shen, Qiwen, Chitchumroonchokchai, Chureeporn, Thomas, Jaisa L, Gushchina, Liubov V, DiSilvestro, David, Failla, Mark L, Ziouzenkova, Ouliana

“…SCOPE: Three fluorescence biosensors were developed based on a 3T3‐L1 preadipocyte line that stably expressed Nfkb‐RE/GFP, Fabp4‐P/CFP, and Nrf2‐P/YFP…”
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High-Resolution Crystal Structure of Spectrin SH3 Domain Fused with a Proline-Rich Peptide by Gushchina, Liubov V., Gabdulkhakov, Azat G., Nikonov, Stanislav V., Filimonov, Vladimir V.

“…A new chimeric protein, named WT-CIIA, was designed by connecting the proline-rich decapeptide PPPVPPYSAG to the C-terminus of the alpha-spectrin SH3 domain…”
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Solution structure and dynamics of the chimeric SH3 domains, SHH- and SHA-“Bergeracs” by Kutyshenko, Victor P., Prokhorov, Dmitry A., Timchenko, Мaria А., Kudrevatykh, Yuri A., Gushchina, Liubov' V., Khristoforov, Vladimir S., Filimonov, Vladimir V., Uversky, Vladimir N.

“…Two chimeric proteins, SHН and SHA of the “SH3-Bergerac” family (where the β-turn N47D48 in spectrin SH3 domain was substituted for KITVNGKTYE or KATANGKTYE…”
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Structural and thermodynamic studies of Bergerac-SH3 chimeras by Gushchina, Liubov' V., Gabdulkhakov, Azat G., Nikonov, Stanislav V., Mateo, Pedro L., Filimonov, Vladimir V.

“…Bergerac-type chimeras of spectrin SH3 were designed by extending a β-hairpin by eight amino acids so that the extension protruded from the domain body like a…”
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Contribution of Oligomeric Forms of Tripartite Motif E3 Ubiquitin Ligase Proteins to Plasma Membrane Repair in Striated Muscle by Gushchina, Liubov V., Alloush, Jenna, Choi, Jin Hyuk, Bhattacharya, Sayak, Beck, Eric, Weisleder, Noah

“…Abstract only Defects in the intrinsic plasma membrane repair function underlie the progression of many human diseases associated with membrane repair…”
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MG29/SYPL2 Contributes to Dysregulation of Lipid Composition and Store Operated Ca2+ Entry in Aging Skeletal Muscle by Vallejo, Julian A., Gushchina, Liubov V., Kotha, Sainath, Brotto, Leticia, Parinandi, Narasimham, Weisleder, Noah, Brotto, Marco

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Abstract 218: The Role of Novel Tripartite Motif Proteins in Sarcolemmal Membrane Repair by Gushchina, Liubov V, Alloush, Jenna, Bhattacharya, Sayak, Xu, Zhaobin, Beck, Eric X, Weisleder, Noah L

“…Abstract only Tripartite motif (TRIM) proteins are a superfamily of coiled-coil-containing RING E3 ligases that function in many cellular processes,…”
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Adipocyte reporter assays: Application for identification of anti-inflammatory and antioxidant properties of mangostin xanthones by Shen, Qiwen, Chitchumroonchokchai, Chureeporn, Thomas, Jaisa L., Gushchina, Liubov V., DiSilvestro, David, Failla, Mark L., Ziouzenkova, Ouliana

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