Synthesis and Characterization of Calcium Silicate Nanoparticles Stabilized with Amino Acids

This work presents the development of a method for the synthesis of calcium silicate nanoparticles stabilized with essential amino acids. CaSiO nanoparticles were obtained through chemical precipitation. In the first stage, the optimal calcium-containing precursor was determined. The samples were ex...

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Bibliographic Details
Published in:	Micromachines (Basel) Vol. 14; no. 2; p. 245
Main Authors:	Blinova, Anastasiya A, Karamirzoev, Abdurasul A, Guseynova, Asiyat R, Maglakelidze, David G, Ilyaeva, Tatiana A, Gusov, Batradz A, Meliksetyants, Avetis P, Pirumian, Mari M, Taravanov, Maxim A, Pirogov, Maxim A, Vakalov, Dmitriy S, Bernyukevich, Tatiana V, Gvozdenko, Alexey A, Nagdalian, Andrey A, Blinov, Andrey V
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 18-01-2023 MDPI
Subjects:	Amino acids Ammonia Bones calcium silicate Calcium silicates Chemical precipitation Chemical synthesis Chloride Energy value Infrared spectroscopy Leucine Lysine Medical research Methionine Nanoparticles Nitrates Phase composition Phase transitions Phenylalanine Photomicrographs Precursors Quantum chemistry scanning electron microscopy Sodium Transplants & implants Tryptophan Valine Wollastonite Russia Czech Republic Netherlands St Petersburg Russia United States > US scanning electron microscopy calcium silicate nanoparticles amino acids
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Summary:	This work presents the development of a method for the synthesis of calcium silicate nanoparticles stabilized with essential amino acids. CaSiO nanoparticles were obtained through chemical precipitation. In the first stage, the optimal calcium-containing precursor was determined. The samples were examined using scanning electron microscopy. It was found that Ca(CH COO) was the optimal calcium-containing precursor. Then, the phase composition of calcium silicate was studied using X-ray phase analysis. The results showed the presence of high-intensity bands in the diffractogram, which characterized the phase of the nanosized CaSiO -wollastonite. In the next stage, the influence of the type of amino acid on the microstructure of calcium silicate was studied. The amnio acids studied were valine, L-leucine, L-isoleucine, L-methionine, L-threonine, L-lysine, L-phenylalanine, and L-tryptophan. The analysis of the SEM micrographs showed that the addition of amino acids did not significantly affect the morphology of the CaSiO samples. The surface of the CaSiO samples, both without a stabilizer and with amino acids, was represented by irregularly shaped aggregates consisting of nanoparticles with a diameter of 50-400 nm. Further, in order to determine the optimal amino acid to use to stabilize nanoparticles, computerized quantum chemical modeling was carried out. Analysis of the data obtained showed that the most energetically favorable interaction was the CaSiO -L-methionine configuration, where the interaction occurs through the amino group of the amino acid; the energy value of which was -2058.497 kcal/mol. To confirm the simulation results, the samples were examined using IR spectroscopy. An analysis of the results showed that the interaction of calcium silicate with L-methionine occurs via the formation of a bond through the NH group of the amino acid.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2072-666X 2072-666X
DOI:	10.3390/mi14020245