Search Results - "Gusella, G. Luca"

Epithelial proliferation and cell cycle dysregulation in kidney injury and disease by Lee, Kyung, Gusella, G Luca, He, John Cijiang

“…Various cellular insults and injury to renal epithelial cells stimulate repair mechanisms to adapt and restore the organ homeostasis. Renal tubular epithelial…”
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The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane by Revenkova, Ekaterina, Liu, Qing, Gusella, G Luca, Iomini, Carlo

“…Cilia-mediated signal transduction involves precise targeting and localization of selected molecules along the ciliary membrane. However, the molecular…”
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Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1 by Lee, Kyung, Boctor, Sylvia, Barisoni, Laura M C, Gusella, G Luca

“…Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney disease (ADPKD), a disorder characterized by the formation of multiple…”
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LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments by Ge, Xuhua, Zhang, Tao, Yu, Xiaoxia, Muwonge, Alecia N, Anandakrishnan, Nanditha, Wong, Nicholas J, Haydak, Jonathan C, Reid, Jordan M, Fu, Jia, Wong, Jenny S, Bhattacharya, Smiti, Cuttitta, Christina M, Zhong, Fang, Gordon, Ronald E, Salem, Fadi, Janssen, William, Hone, James C, Zhang, Aihua, Li, Hong, He, John C, Gusella, G Luca, Campbell, Kirk N, Azeloglu, Evren U

“…Maintenance of the intricate interdigitating morphology of podocytes is crucial for glomerular filtration. One of the key aspects of specialized podocyte…”
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Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons by Rozenfeld, Raphael, Bushlin, Ittai, Gomes, Ivone, Tzavaras, Nikos, Gupta, Achla, Neves, Susana, Battini, Lorenzo, Gusella, G Luca, Lachmann, Alexander, Ma'ayan, Avi, Blitzer, Robert D, Devi, Lakshmi A

“…A fundamental question in G protein coupled receptor biology is how a single ligand acting at a specific receptor is able to induce a range of signaling that…”
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Autophagy Limits Endotoxemic Acute Kidney Injury and Alters Renal Tubular Epithelial Cell Cytokine Expression by Leventhal, Jeremy S, Ni, Jie, Osmond, Morgan, Lee, Kyung, Gusella, G Luca, Salem, Fadi, Ross, Michael J

“…Sepsis related acute kidney injury (AKI) is a common in-hospital complication with a dismal prognosis. Our incomplete understanding of disease pathogenesis has…”
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Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium by Blitzer, Andrea L, Panagis, Lampros, Gusella, G. Luca, Danias, John, Mlodzik, Marek, Iomini, Carlo

“…Primary cilia are required for several signaling pathways, but their function in cellular morphogenesis is poorly understood. Here we show that emergence of an…”
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Loss of polycystin-1 causes centrosome amplification and genomic instability by Battini, Lorenzo, Macip, Salvador, Fedorova, Elena, Dikman, Steven, Somlo, Stefan, Montagna, Cristina, Gusella, G. Luca

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic disease predominantly caused by alteration or dysregulation of the PKD1…”
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Cilium, centrosome and cell cycle regulation in polycystic kidney disease by Lee, Kyung, Battini, Lorenzo, Gusella, G. Luca

“…Polycystic kidney disease is the defining condition of a group of common life-threatening genetic disorders characterized by the bilateral formation and…”
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Prothymosin-α Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways by Gusella, G Luca, Teixeira, Avelino, Aberg, Judith, Uversky, Vladimir N, Mosoian, Arevik

“…Prothymosin α (ProTα) (isoform 2: iso2) is a widely distributed, small acidic protein with intracellular and extracellular-associated functions. Recently, we…”
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Prothymosin-α inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction by Mosoian, Arevik, Teixeira, Avelino, Burns, Colin S, Sander, Leif E, Gusella, G. Luca, He, Cijiang, Blander, J. Magarian, Klotman, Paul, Klotman, Mary E

“…Induction of type I interferons (IFN) is a central feature of innate immune responses to microbial pathogens and is mediated via Toll-like receptor…”
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Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease by ROSS, Michael J, WOSNITZER, Matthew S, KLOTMAN, Mary E, KLOTMAN, Paul E, ROSS, Michael D, GRANELLI, Benedetta, LUCA GUSELLA, G, HUSAIN, Mohammad, KAUFMAN, Lewis, VASIEVICH, Matthew, D'AGATI, Vivette D, WILSON, Patricia D

“…Dysregulated apoptosis of renal tubular epithelial cells (RTEC) is an important component of the pathogenesis of several renal diseases, including…”
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cGAS Activation Accelerates the Progression of Autosomal Dominant Polycystic Kidney Disease by Yoo, Miran, Haydak, Jonathan C, Azeloglu, Evren U, Lee, Kyung, Gusella, G Luca

“…The renal immune infiltrate observed in autosomal polycystic kidney disease contributes to the evolution of the disease. Elucidating the cellular mechanisms…”
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HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes by HUSAIN, Mohammad, GUSELLA, G. Luca, KLOTMAN, Mary E, GELMAN, Irwin H, ROSS, Michael D, SCHWARTZ, Elissa J, CARA, Andrea, KLOTMAN, Paul E

“…HIV-associated nephropathy (HIVAN) is now the third leading cause of end-stage renal disease in the African American population. HIV-1 infects renal tubular…”
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SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation by Cai, Hong, Chen, Ya, Feng, Ye, Asadi, Morad, Kaufman, Lewis, Lee, Kyung, Kehrer, Thomas, Miorin, Lisa, Garcia-Sastre, Adolfo, Gusella, G. Luca, Gu, Leyi, Ni, Zhaohui, Mou, Shan, He, John Cijiang, Zhou, Weibin

“…Acute kidney injury occurs frequently in COVID-19 patients infected by the coronavirus SARS-CoV-2, and infection of kidney cells by this virus has been…”
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Tubular deficiency of ABCA1 augments cholesterol- and Na + -dependent effects on systemic blood pressure in male mice by Carneiro de Oliveira, Karin, Wei, Yuan, Repetti, Robert L, Meth, Jennifer, Majumder, Nomrota, Sapkota, Ananda, Gusella, G Luca, Rohatgi, Rajeev

“…Dyslipidemia, with changes in plasma membrane (PM) composition, is associated with hypertension, while rising PM cholesterol induces Na channel activity. We…”
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Characterization of human metapneumovirus infection of myeloid dendritic cells by Tan, Maria C, Battini, Lorenzo, Tuyama, Ana C, Macip, Salvador, Melendi, Guillermina A, Horga, Maria-Arantxa, Luca Gusella, G

“…Abstract Recent in vivo studies suggest that hMPV is a poor inducer of inflammatory cytokines and that clinical symptoms may not be related to immune-mediated…”
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Integrin-β 1 is required for the renal cystogenesis caused by ciliary defects by Yoo, Miran, Barisoni, Laura M C, Lee, Kyung, Gusella, G Luca

“…Defects in the function of primary cilia are commonly associated with the development of renal cysts. On the other hand, the intact cilium appears to…”
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Computational study of biomechanical drivers of renal cystogenesis by Ateshian, Gerard A., Spack, Katherine A., Hone, James C., Azeloglu, Evren U., Gusella, G. Luca

“…Renal cystogenesis is the pathological hallmark of autosomal dominant polycystic kidney disease, caused by PKD1 and PKD2 mutations. The formation of renal…”
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Reduced decay-accelerating factor expression promotes complement-mediated cystogenesis in murine ADPKD by Bin, Sofia, Yoo, Miran, Molinari, Paolo, Gentile, Micaela, Budge, Kelly, Cantarelli, Chiara, Khan, Yaseen, La Manna, Gaetano, Baldwin, William M, Dvorina, Nina, Cravedi, Paolo, Gusella, G Luca

“…Patients with autosomal dominant polycystic kidney disease (ADPKD), a genetic disease due to mutations of the PKD1 or PKD2 gene, show signs of complement…”
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