Search Results - "Gusella, G. L."

Novel integrase-defective lentiviral episomal vectors for gene transfer by Vargas, Jr, J, Gusella, G L, Najfeld, V, Klotman, M E, Cara, A

“…High levels of circular viral extrachromosomal DNA (E-DNA) are normally produced after infection with integration-competent and -incompetent lentiviruses…”
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Interleukin 1 Induction of the c-jun Promoter by Muegge, K., Vila, M., Gusella, G. L., Musso, T., Herrlich, P., Stein, B., Durum, S. K.

“…Interleukin 1 (IL-1) induces pleiotropic effects in many cell types during inflammation and immunity. We have recently shown how the IL-1 signal is transmitted…”
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IL-2 up-regulates but IFN-gamma suppresses IL-8 expression in human monocytes by Gusella, GL, Musso, T, Bosco, MC, Espinoza-Delgado, I, Matsushima, K, Varesio, L

“…IL-2 has pleiotropic properties and is a potent activator of monocytic functions. Since monocytes are an important source of the chemoattractant cytokine IL-8,…”
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Interleukin-2 and human monocyte activation by Espinoza-Delgado, I, Bosco, M C, Musso, T, Gusella, G L, Longo, D L, Varesio, L

“…The recognition of the monocyte/macrophage-activating properties of IL-2 has broadened our image of the biological effects of this lymphokine from those of a T…”
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Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy by Marras, Daniele, Bruggeman, Leslie A, Gao, Feng, Tanji, Nozomu, Mansukhani, Mahesh M, Cara, Andrea, Ross, Michael D, Gusella, G Luca, Benson, Gary, D'Agati, Vivette D, Hahn, Beatrice H, Klotman, Mary E, Klotman, Paul E

“…HIV-associated nephropathy is a clinicopathologic entity that includes proteinuria, focal segmental glomerulosclerosis often of the collapsing variant, and…”
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Development of a novel screen for protease inhibitors by Gillim, L, Gusella, G L, Vargas, Jr, J, Marras, D, Klotman, M E, Cara, A

“…We have developed a novel plasmid-based, quantitative, in vitro screen to test the protease-inhibiting activities of existing and newly discovered agents…”
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Dexamethasone inhibits the induction of monocyte chemotactic-activating factor production by IL-1 or tumor necrosis factor by Mukaida, N, Zachariae, CC, Gusella, GL, Matsushima, K

“…Recently purified and molecularly cloned monocyte chemotactic and activating factor (MCAF) may play a major role in recruiting and activating monocytes in the…”
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Inhibition of HIV-1 replication by combined expression of gag dominant negative mutant and a human ribonuclease in a tightly controlled HIV-1 inducible vector by CARA, A, RYBAK, S. M, NEWTON, D. L, CROWLEY, R, ROTTSCHAFER, S. E, REITZ, M. S, GUSELLA, G. L

“…An HIV-1-based expression vector has been constructed that produces protective genes tightly regulated by HIV-1 Tat and Rev proteins. The vector contains…”
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Transforming Growth Factor β Downregulates Interleukin-1 (IL-1)-Induced IL-6 Production by Human Monocytes by Musso, Tiziana, Espinoza-Delgado, Igor, Pulkki, Kari, Gusella, Gabriele L., Longo, Dan L., Varesio, Luigi

“…We investigated the effects of transforming growth factor β (TGFβ) on the induction by interleukin-1β (IL-1β) of IL-6 in human monocytes. We found that IL-1β…”
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Leukemia inhibitory factor induces interleukin-8 and monocyte chemotactic and activating factor in human monocytes : differential regulation by interferon-γ by MUSSO, T, BADOLATO, R, LONGO, D. L, GUSELLA, G. L, VARESIO, L

“…Leukemia inhibitory factor (LIF) is a cytokine released at the site of injuries where there is a recruitment of monocytes and polymorphonuclear cells. We…”
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Regulation by interleukin-2 (IL-2) and interferon γ of IL-2 receptor γ chain gene expression in human monocytes by BOSCO, M. C, ESPINOZA-DELGADO, I, SCHWABE, M, GUSELLA, G. L, LONGO, D. L, SUGAMURA, K, VARESIO, L

“…The interleukin-2 receptor gamma chain (IL-2R gamma) gene codes for a subunit of the IL-2R and is expressed in human lymphoid cells. The present study was…”
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IL-2 induces IL-6 production in human monocytes by Musso, T, Espinoza-Delgado, I, Pulkki, K, Gusella, GL, Longo, DL, Varesio, L

“…IL-2 is a potent activator of effector and secretory activities of human monocytes. Since monocytes are an important source of IL-6, we investigated whether…”
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Regulation of IL-2 receptor subunit genes in human monocytes. Differential effects of IL-2 and IFN-gamma by Espinoza-Delgado, I, Longo, DL, Gusella, GL, Varesio, L

“…We investigated the effects of IFN-gamma and IL-2 on IL-2R alpha and beta mRNA expression in human monocytes. Low basal expression of IL-2R beta mRNA was…”
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A Functional Protein Kinase C Is Required for Induction of 2-5A Synthetase by Recombinant Interferon-αA in Daudi Cells by Faltynek, C R, Princler, G L, Gusella, G L, Varesio, L, Radzioch, D

“…Treatment of Daudi B lymphoblastoid cells with interferon (IFN)-α or -β has been reported (Yap, W. H., Teo, T. S., and Tan, Y. H. (1986) Science 234, 355–358)…”
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LPS-inducible nuclear factor in human monocytes that binds the negative regulatory element of the HIV LTR by Musso, T, Bosco, M C, Longo, D L, Espinoza-Delgado, I, Sica, A, Cox, G W, Gusella, G L, Forni, G, Varesio, L

“…We studied the constitutive and lipopolysaccharide (LPS)-induced expression of nuclear protein binding to the negative regulatory element (NRE) of the human…”
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Selective transformation of host lymphocytes in vivo by retrovirus- producing macrophages by Bosco, MC, Musso, T, Gusella, GL, Giovarelli, M, Forni, M, Soleti, A, Masuelli, L, Modesti, A, Forni, G, Varesio, L

“…Macrophage-mediated retroviral transformation of host cells was studied in vivo utilizing the cloned murine macrophage-line GG2EE, generated by in vitro…”
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IL-2 enhances c-fms expression in human monocytes by Espinoza-Delgado, I, Longo, DL, Gusella, GL, Varesio, L

“…We investigated the effects of IL-2 and IFN-gamma on the expression of the proto-oncogene c-fms mRNA, which encodes for the macrophage CSF receptor. Low…”
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Lipopolysaccharide, but not IFN-gamma, down-regulates c-fms mRNA proto- oncogene expression in murine macrophages by Gusella, GL, Ayroldi, E, Espinoza-Delgado, I, Varesio, L

“…In the present study we analyzed the effects of two macrophage activators, bacterial LPS and IFN-gamma, on the expression of the c-fms proto-oncogene in the…”
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Lentiviral gene transduction of kidney by Gusella, G Luca, Fedorova, Elena, Hanss, Basil, Marras, Daniele, Klotman, Mary E, Klotman, Paul E

“…Gene transfer into kidney holds great potential as a novel therapeutic approach. We have studied the transduction of kidney in vivo after delivery of…”
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IL-6 signals inhibition of cell adhesion in melanoma A375-C6 by Schwabe, M, Deryugina, E I, Bosco, M C, Gusella, G L, Reinisch, W, Kung, H F, Bourdon, M A

“…IL-6 has been found to be a potent inhibitor of melanoma A375-C6 cell adhesion, in addition to its known action in arresting cells at G1/G0 phase of the cell…”
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