Search Results - "Guse, Kilian"

Proteoglycan 4 expression protects against the development of osteoarthritis by Ruan, Merry Z C, Erez, Ayelet, Guse, Kilian, Dawson, Brian, Bertin, Terry, Chen, Yuqing, Jiang, Ming-Ming, Yustein, Jason, Gannon, Francis, Lee, Brendan H L

“…Osteoarthritis (OA) is a common degenerative condition that afflicts more than 70% of the population between 55 and 77 years of age. Although its prevalence is…”
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Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients by CERULLO, Vincenzo, PESONEN, Sari, RAJECKI, Maria, KANGASNIEMI, Lotta, GUSE, Kilian, HELMINEN, Andreas, AHTIAINEN, Laura, RISTIMÄKI, Ari, RÄISÄNEN-SOKOLOWSKI, Anne, HAAVISTO, Elina, OKSANEN, Minna, KARLI, Eerika, DIACONU, Lulia, KARIOJA-KALLIO, Aila, HOLM, Sirkka-Liisa, KOURI, Mauri, JOENSUU, Timo, KANERVA, Anna, HEMMINKI, Akseli, ESCUTENAIRE, Sophie, ARSTILA, Petteri T, UGOLINI, Matteo, NOKISALMI, Petri, RAKI, Mari, LAASONEN, Leena, SÄRKIOJA, Merja

“…Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific…”
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Interleukins, growth factors, and transcription factors are key targets for gene therapy in osteoarthritis: A scoping review by Uebelhoer, Melanie, Lambert, Cécile, Grisart, Juliane, Guse, Kilian, Plutizki, Stanislav, Henrotin, Yves

“…Osteoarthritis (OA) is the most common degenerative joint disease, characterized by a progressive loss of cartilage associated with synovitis and subchondral…”
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Antiangiogenic Arming of an Oncolytic Vaccinia Virus Enhances Antitumor Efficacy in Renal Cell Cancer Models by Guse, Kilian, Sloniecka, Marta, Diaconu, Iulia, Ottolino-Perry, Kathryn, Tang, Nan, Ng, Calvin, Le Boeuf, Fabrice, Bell, John C, McCart, J Andrea, Ristimäki, Ari, Pesonen, Sari, Cerullo, Vincenzo, Hemminki, Akseli

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells by Parviainen, Suvi, Autio, Karoliina, Vähä-Koskela, Markus, Guse, Kilian, Pesonen, Sari, Rosol, Thomas J, Zhao, Fang, Hemminki, Akseli

“…Vaccinia virus is a large, enveloped virus of the poxvirus family. It has broad tropism and typically virus replication culminates in accumulation and lytic…”
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Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity by Hirvinen, Mari, Capasso, Cristian, Guse, Kilian, Garofalo, Mariangela, Vitale, Andrea, Ahonen, Marko, Kuryk, Lukasz, Vähä-Koskela, Markus, Hemminki, Akseli, Fortino, Vittorio, Greco, Dario, Cerullo, Vincenzo

“…In oncolytic virotherapy, the ability of the virus to activate the immune system is a key attribute with regard to long-term antitumor effects. Vaccinia…”
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Triple-Targeted Oncolytic Adenoviruses Featuring the Cox2 Promoter, E1A Transcomplementation, and Serotype Chimerism for Enhanced Selectivity for Ovarian Cancer Cells by Bauerschmitz, Gerd J, Guse, Kilian, Kanerva, Anna, Menzel, Artur, Herrmann, Isabell, Desmond, Renee A, Yamamoto, Masato, Nettelbeck, Dirk M, Hakkarainen, Tanja, Dall, Peter, Curiel, David T, Hemminki, Akseli

“…Conditionally replicating adenoviruses (CRAd's) feature selective replication in and killing of tumor cells. Initial clinical studies with relatively…”
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Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses by Guse, Kilian, Ranki, Tuuli, Ala-Opas, Martti, Bono, Petri, Särkioja, Merja, Rajecki, Maria, Kanerva, Anna, Hakkarainen, Tanja, Hemminki, Akseli

“…Renal cancer is a common and deadly disease that lacks curative treatments when metastatic. Here, we have used oncolytic adenoviruses, a promising…”
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Safety and biodistribution of a double-deleted oncolytic vaccinia virus encoding CD40 ligand in laboratory Beagles by Autio, Karoliina, Knuuttila, Anna, Kipar, Anja, Pesonen, Sari, Guse, Kilian, Parviainen, Suvi, Rajamäki, Minna, Laitinen-Vapaavuori, Outi, Vähä-Koskela, Markus, Kanerva, Anna, Hemminki, Akseli

“…We evaluated adverse events, biodistribution and shedding of oncolytic vaccinia virus encoding CD40 ligand in two Beagles, in preparation for a phase 1 trial…”
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Oncolytic vaccinia virus for the treatment of cancer by Guse, Kilian, Cerullo, Vincenzo, Hemminki, Akseli

“…Gene therapy offers promising approaches for the development of anticancer agents with new modes of action. Among gene therapy vectors, vaccinia virus has…”
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Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer by Liikanen, Ilkka, Tähtinen, Siri, Guse, Kilian, Gutmann, Theresia, Savola, Paula, Oksanen, Minna, Kanerva, Anna, Hemminki, Akseli

“…Monoclonal anti-HER2 antibody trastuzumab has significantly improved the survival of patients with HER2-overexpressing tumors. Nevertheless, systemic antibody…”
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Disease‐Modifying Osteoarthritis Treatment With Interleukin‐1 Receptor Antagonist Gene Therapy in Small and Large Animal Models by Nixon, Alan J., Grol, Matthew W., Lang, Hayley M., Ruan, Merry Z. C., Stone, Adrianne, Begum, Laila, Chen, Yuqing, Dawson, Brian, Gannon, Francis, Plutizki, Stanislav, Lee, Brendan H. L., Guse, Kilian

“…Objective Gene therapy holds great promise for the treatment of osteoarthritis (OA) because a single intraarticular injection can lead to long‐term expression…”
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Mitochondrial myopathy induces a starvation-like response by Tyynismaa, Henna, Carroll, Christopher J., Raimundo, Nuno, Ahola-Erkkilä, Sofia, Wenz, Tina, Ruhanen, Heini, Guse, Kilian, Hemminki, Akseli, Peltola-Mjøsund, Katja E., Tulkki, Valtteri, Orešič, Matej, Moraes, Carlos T., Pietiläinen, Kirsi, Hovatta, Iiris, Suomalainen, Anu

“…Mitochondrial respiratory chain (RC) deficiency is among the most common causes of inherited metabolic disease, but its physiological consequences are poorly…”
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Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF by Koski, Anniina, Kangasniemi, Lotta, Escutenaire, Sophie, Pesonen, Sari, Cerullo, Vincenzo, Diaconu, Iulia, Nokisalmi, Petri, Raki, Mari, Rajecki, Maria, Guse, Kilian, Ranki, Tuuli, Oksanen, Minna, Holm, Sirkka-Liisa, Haavisto, Elina, Karioja-Kallio, Aila, Laasonen, Leena, Partanen, Kaarina, Ugolini, Matteo, Helminen, Andreas, Karli, Eerika, Hannuksela, Päivi, Pesonen, Saila, Joensuu, Timo, Kanerva, Anna, Hemminki, Akseli

“…Augmenting antitumor immunity is a promising way to enhance the potency of oncolytic adenoviral therapy. Granulocyte–macrophage colony–stimulating factor…”
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Oncolytic adenovirus and doxorubicin‐based chemotherapy results in synergistic antitumor activity against soft‐tissue sarcoma by Siurala, Mikko, Bramante, Simona, Vassilev, Lotta, Hirvinen, Mari, Parviainen, Suvi, Tähtinen, Siri, Guse, Kilian, Cerullo, Vincenzo, Kanerva, Anna, Kipar, Anja, Vähä‐Koskela, Markus, Hemminki, Akseli

“…Despite originating from several different tissues, soft‐tissue sarcomas (STS) are often grouped together as they share mesenchymal origin and treatment…”
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Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors by Pesonen, Sari, Diaconu, Iulia, Cerullo, Vincenzo, Escutenaire, Sophie, Raki, Mari, Kangasniemi, Lotta, Nokisalmi, Petri, Dotti, Gianpietro, Guse, Kilian, Laasonen, Leena, Partanen, Kaarina, Karli, Eerika, Haavisto, Elina, Oksanen, Minna, Karioja-Kallio, Aila, Hannuksela, Päivi, Holm, Sirkka-Liisa, Kauppinen, Satu, Joensuu, Timo, Kanerva, Anna, Hemminki, Akseli

“…The safety of oncolytic viruses for treatment of cancer has been shown in clinical trials while antitumor efficacy has often remained modest. As expression of…”
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Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors by NOKISALMI, Petri, PESONEN, Sari, GUSE, Kilian, RAJECKI, Maria, KANGASNIEMI, Lotta, HAAVISTO, Elina, KARIOJA-KALLIO, Aila, HANNUKSELA, Päivi, OKSANEN, Minna, KANERVA, Anna, JOENSUU, Timo, AHTIAINEN, Laura, ESCUTENAIRE, Sophie, HEMMINKI, Akseli, SÄRKIOJA, Merja, RAKI, Mari, CERULLO, Vincenzo, LAASONEN, Leena, ALEMANY, Ramon, ROJAS, Juan, CASCALLO, Manel

“…Twenty-one patients with cancer were treated with a single round of oncolytic adenovirus ICOVIR-7. ICOVIR-7 features an RGD-4C modification of the fiber…”
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An oncolytic adenovirus able to express a full-length functional anti-Her2 monoclonal antibody from tumor cells by Savola, Paula, Liikanen, Ilkka, Gutmann, Theresia, Guse, Kilian, Hemminki, Akseli

“…Background and hypothesis: Monoclonal antibodies are useful tools for treatment of cancer and many other diseases. However, overall clinical benefits -…”
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Oncolytic Adenoviruses Kill Breast Cancer Initiating CD44 CD24 Cells

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Nitric-Oxide Supplementation for Treatment of Long-Term Complications in Argininosuccinic Aciduria by Nagamani, Sandesh C.S., Campeau, Philippe M., Shchelochkov, Oleg A., Premkumar, Muralidhar H., Guse, Kilian, Brunetti-Pierri, Nicola, Chen, Yuqing, Sun, Qin, Tang, Yaoping, Palmer, Donna, Reddy, Anilkumar K., Li, Li, Slesnick, Timothy C., Feig, Daniel I., Caudle, Susan, Harrison, David, Salviati, Leonardo, Marini, Juan C., Bryan, Nathan S., Erez, Ayelet, Lee, Brendan

“…Argininosuccinate lyase (ASL) is required for the synthesis and channeling of L-arginine to nitric oxide synthase (NOS) for nitric oxide (NO) production…”
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