Search Results - "Guscott, Martin"

Differential contribution of GABAA receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands by Fradley, Rosa L., Guscott, Martin R., Bull, Sharlene, Hallett, David J., Goodacre, Simon C., Wafford, Keith A., Garrett, ELizabeth M., Newman, Richard J., O'Meara, Gillian F., Whiting, Paul J., Rosahl, Thomas W., Dawson, Gerard R., Reynolds, David S., Atack, John R.

“…Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABAA receptors containing either an α1, α2, α3 or…”
Get full text

Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands by Fradley, Rosa L, Guscott, Martin R, Bull, Sharlene, Hallett, David J, Goodacre, Simon C, Wafford, Keith A, Garrett, Elizabeth M, Newman, Richard J, O'Meara, Gillian F, Whiting, Paul J, Rosahl, Thomas W, Dawson, Gerard R, Reynolds, David S, Atack, John R

“…Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABA(A) receptors containing either an alpha1,…”
Get full text

The effect of (±)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze by Guscott, Martin R., Clarke, Hannah F., Murray, Fraser, Grimwood, Sarah, Bristow, Linda J., Hutson, Peter H.

“…It is well established that the NMDA receptor antagonists block hippocampal long-term potentiation and impair acquisition in the Morris watermaze task,…”
Get full text

Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1 by Blackaby, Wesley P, Lewis, Richard T, Thomson, Joanne L, Jennings, Andrew S. R, Goodacre, Simon C, Street, Leslie J, MacLeod, Angus M, Pike, Andrew, Wood, Suzanne, Thomas, Steve, Brown, Terry A, Smith, Alison, Pillai, Gopalan, Almond, Sarah, Guscott, Martin R, Burns, H. Donald, Eng, Waisi, Ryan, Christine, Cook, Jacquelynn, Hamill, Terence G

“…Amalgamation of the structure−activity relationship of two series of GlyT1 inhibitors developed at Merck led to the discovery of a clinical candidate, compound…”
Get full text

A Systematic Review of High-Dose Methotrexate for Adults with Primary Central Nervous System Lymphoma by Villanueva, Gabriela, Guscott, Martin, Schaiquevich, Paula, Sampor, Claudia, Combs, Ryan, Tentoni, Nicolás, Hwang, Miriam, Lowe, Jennifer, Howard, Scott

“…Primary central nervous system lymphoma (PCNSL) is a highly aggressive non-Hodgkin lymphoma that is confined within the CNS. Due to its ability to cross the…”
Get full text

Research and Care Networks in Acute Leukemia As a Model for Global Healthcare Collaboration by Guscott, Martin R, Cooper, Stacy L, Bagai, Poonam, Bleyer, Archie, Buddington, Randal K, Douer, Dan, Chong, Tina B, Combs, Ryan R, Hylton, Jennifer L, Ines-Villanueva, Gabriela, Lowe, Jennifer A, Pandey, Rishabh, Patel, Aman N, Howard, Scott C

“…Introduction: Clinicians in academia face four major career challenges: 1.Gaining clinical advice from colleagues experienced in a particular disease or…”
Get full text

Insights from a pharmacometric analysis of HDMTX in adults with cancer: Clinically relevant covariates for application in precision dosing by Ibarra, Manuel, Combs, Ryan, Taylor, Zachary L., Ramsey, Laura B., Mikkelsen, Torben, Buddington, Randal K., Heldrup, Jesper, Barreto, Jason N., Guscott, Martin, Lowe, Jennifer, Hurmiz, Charles, Marada, Suresh, Howard, Scott C., Schaiquevich, Paula

“…Aims High‐dose methotrexate (HDMTX) is an essential part of the treatment of several adult and paediatric malignancies. Despite meticulous supportive care…”
Get full text

The role of GABAAβ2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole by Groves, James O., Guscott, Martin R., Hallett, David J., Rosahl, Thomas W., Pike, Andrew, Davies, Amy, Wafford, Keith A., Reynolds, David S.

“…The majority of inhibitory neurotransmission in the brain is mediated by the γ‐aminobutyric acid (GABA) type A (GABAA) receptor. The anticonvulsant loreclezole…”
Get full text

The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole by Groves, James O, Guscott, Martin R, Hallett, David J, Rosahl, Thomas W, Pike, Andrew, Davies, Amy, Wafford, Keith A, Reynolds, David S

“…The majority of inhibitory neurotransmission in the brain is mediated by the gamma-aminobutyric acid (GABA) type A (GABA(A)) receptor. The anticonvulsant…”
Get full text

The role of GABA A β2 subunit‐containing receptors in mediating the anticonvulsant and sedative effects of loreclezole by Groves, James O., Guscott, Martin R., Hallett, David J., Rosahl, Thomas W., Pike, Andrew, Davies, Amy, Wafford, Keith A., Reynolds, David S.

“…The majority of inhibitory neurotransmission in the brain is mediated by the γ‐aminobutyric acid (GABA) type A (GABA A ) receptor. The anticonvulsant…”
Get full text

The role of GABA sub(A) beta 2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole by Groves, James O, Guscott, Martin R, Hallett, David J, Rosahl, Thomas W, Pike, Andrew, Davies, Amy, Wafford, Keith A, Reynolds, David S

“…The majority of inhibitory neurotransmission in the brain is mediated by the gamma -aminobutyric acid (GABA) type A (GABA sub(A)) receptor. The anticonvulsant…”
Get full text

Differential contribution of GABA sub(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands by Fradley, Rosa L, Guscott, Martin R, Bull, Sharlene, Hallett, David J, Goodacre, Simon C, Wafford, Keith A, Garrett, ELizabeth M, Newman, Richard J, O'Meara, Gillian F, Whiting, Paul J, Rosahl, Thomas W, Dawson, Gerard R, Reynolds, David S, Atack, John R

“…Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABA sub(A) receptors containing either an a1, a2,…”
Get full text