Search Results - "Gurung, Sarah P."

The importance of loop length on the stability of i-motif structures by Gurung, Sarah P, Schwarz, Christine, Hall, James P, Cardin, Christine J, Brazier, John A

“…Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to…”
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Structural Studies Reveal Enantiospecific Recognition of a DNA G‐Quadruplex by a Ruthenium Polypyridyl Complex by McQuaid, Kane, Abell, Holly, Gurung, Sarah P., Allan, David R., Winter, Graeme, Sorensen, Thomas, Cardin, David J., Brazier, John A., Cardin, Christine J., Hall, James P.

“…By using X‐ray crystallography, we show that the complexes Λ/Δ‐[Ru(TAP)2(11‐CN‐dppz)]2+ (TAP=1,4,5,8‐tetraazaphenanthrene, dppz=dipyridophenazine) bind DNA…”
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Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy by Hall, James P., Poynton, Fergus E., Keane, Páraic M., Gurung, Sarah P., Brazier, John A., Cardin, David J., Winter, Graeme, Gunnlaugsson, Thorfinnur, Sazanovich, Igor V., Towrie, Michael, Cardin, Christine J., Kelly, John M., Quinn, Susan J.

“…To understand the molecular origins of diseases caused by ultraviolet and visible light, and also to develop photodynamic therapy, it is important to resolve…”
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Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes by Pages, Benjamin J., Gurung, Sarah P., McQuaid, Kane, Hall, James P., Cardin, Christine J., Brazier, John A.

“…A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen) 2 (dppz)] 2+ with i-motif DNA containing thymine loops of various lengths. In the presence of…”
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The influence of loops on the binding of the [Ru(phen) 2 dppz] 2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy by Baptista, Frederico R, Devereux, Stephen J, Gurung, Sarah P, Hall, James P, Sazanovich, Igor V, Towrie, Michael, Cardin, Christine J, Brazier, John A, Kelly, John M, Quinn, Susan J

“…Ultrafast time resolved infrared (TRIR) is used to report on the binding site of the "light-switch" complex [Ru(phen) (dppz)] 1 to i-motif structures in…”
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Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a Ru II Complex due to Structural Change in the Minor Groove by Keane, Páraic M, Hall, James P, Poynton, Fergus E, Poulsen, Bjørn C, Gurung, Sarah P, Clark, Ian P, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J, Cardin, Christine J, Kelly, John M

“…Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference…”
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Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects by Hall, James P., Gurung, Sarah P., Henle, Jessica, Poidl, Patrick, Andersson, Johanna, Lincoln, Per, Winter, Graeme, Sorensen, Thomas, Cardin, David J., Brazier, John A., Cardin, Christine J.

“…X‐ray crystal structures of three Λ‐[Ru(L)2dppz]2+ complexes (dppz=dipyridophenazine; L=1,10‐phenanthroline (phen), 2,2′‐bipyridine (bpy)) bound to…”
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Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy by Keane, Páraic M., Baptista, Frederico R., Gurung, Sarah P., Devereux, Stephen J., Sazanovich, Igor V., Towrie, Michael, Brazier, John A., Cardin, Christine J., Kelly, John M., Quinn, Susan J.

“…UV‐generated excited states of cytosine (C) nucleobases are precursors to mutagenic photoproduct formation. The i‐motif formed from C‐rich sequences is known…”
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Back Cover: Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy (ChemPhysChem 9/2016) by Keane, Páraic M., Baptista, Frederico R., Gurung, Sarah P., Devereux, Stephen J., Sazanovich, Igor V., Towrie, Michael, Brazier, John A., Cardin, Christine J., Kelly, John M., Quinn, Susan J.

“…The Back Cover picture shows that UV excitation of intramolecular i‐motif DNA yields a rich transient infrared spectrum with unusually long excited state…”
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Structural Studies Reveal Enantiospecific Recognition of a DNA G‐Quadruplex by a Ruthenium Polypyridyl Complex by McQuaid, Kane, Abell, Holly, Gurung, Sarah P., Allan, David R., Winter, Graeme, Sorensen, Thomas, Cardin, David J., Brazier, John A., Cardin, Christine J., Hall, James P.

“…By using X‐ray crystallography, we show that the complexes Λ/Δ‐[Ru(TAP)2(11‐CN‐dppz)]2+ (TAP=1,4,5,8‐tetraazaphenanthrene, dppz=dipyridophenazine) bind DNA…”
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DNA I-motifs: beyond the double helix by Gurung, Sarah P., Hall, James P., Brazier, John A., Winter, Graeme, Sorensen, Thomas, Cardin, Christine J.

“…Abstract only…”
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Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a RuII Complex due to Structural Change in the Minor Groove by Keane, Páraic M, Hall, James P, Poynton, Fergus E, Poulsen, Bjørn C, Gurung, Sarah P, Clark, Ian P, Sazanovich, Igor V, Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J, Cardin, Christine J, Kelly, John M

“…Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference…”
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Inosine Can Increase DNA′s Susceptibility to Photo‐oxidation by a Ru II Complex due to Structural Change in the Minor Groove by Keane, Páraic M., Hall, James P., Poynton, Fergus E., Poulsen, Bjørn C., Gurung, Sarah P., Clark, Ian P., Sazanovich, Igor V., Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J., Cardin, Christine J., Kelly, John M.

“…Abstract Key to the development of DNA‐targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding…”
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Inosine Can Increase DNA′s Susceptibility to Photo‐oxidation by a RuII Complex due to Structural Change in the Minor Groove by Keane, Páraic M., Hall, James P., Poynton, Fergus E., Poulsen, Bjørn C., Gurung, Sarah P., Clark, Ian P., Sazanovich, Igor V., Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J., Cardin, Christine J., Kelly, John M.

“…Key to the development of DNA‐targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference…”
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X-ray crystallographic and photophysical studies of DNA i-motifs by Gurung, Sarah P., Hall, James P., Winter, Graeme, Brazier, John A., Hussain, Rohanah, Siligardi, Giuliano, Sorensen, Thomas, Cardin, Christine J.

“…Abstract only…”
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DNA structure and dynamics – a combinational approach by Hall, James P., Gurung, Sarah P., Keane, Paraic M., Poynton, Fergus E., Cardin, David J., Sorensen, Thomas, Winter, Graeme, Gunnlaugsson, Thorfinnur, Sazanovich, Igor V., Towrie, Mike, Kelly, John M., Quinn, Susan J., Brazier, John A., Cardin, Christine J.

“…Abstract only…”
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Combining X-ray crystallography and ultrafast infrared spectroscopy – monitoring photo-induced guanine oxidation by [Ru(TAP) 2 (dppz)] 2 by Hall, James P., Poynton, Fergus E., Keane, Páraic M., Gurung, Sarah P., Brazier, John A., Cardin, David J., Winter, Graeme, Gunnlaugsson, Thorfinnur, Sazanovich, Igor V., Towrie, Michael, Cardin, Christine J., Kelly, John M., Quinn, Susan J.

“…Abstract only…”
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Binding of a G-quadruplex from Streptococcus pneumoniae to [Ru(phen) 2 dppz] 2 by Gurung, Sarah P., Hall, James P., Cardin, Christine J., Brazier, John A.

“…Abstract only…”
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