Search Results - "Gurule, Natalia J."

Upregulation of complement proteins in lung cancer cells mediates tumor progression by Kleczko, Emily K, Poczobutt, Joanna M, Navarro, Andre C, Laskowski, Jennifer, Johnson, Amber M, Korpela, Sean P, Gurule, Natalia J, Heasley, Lynn E, Hopp, Katharina, Weiser-Evans, Mary C M, Gottlin, Elizabeth B, Bushey, Ryan T, Campa, Michael J, Patz, Jr, Edward F, Thurman, Joshua M, Nemenoff, Raphael A

“…, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress…”
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A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer by Gurule, Natalia J., McCoach, Caroline E., Hinz, Trista K., Merrick, Daniel T., Van Bokhoven, Adriaan, Kim, Jihye, Patil, Tejas, Calhoun, Jacob, Nemenoff, Raphael A., Tan, Aik Choon, Doebele, Robert C., Heasley, Lynn E.

“…Tyrosine kinase inhibitors (TKIs) targeting EGFR-mutant lung cancers promote a range of tumor regression responses to yield variable residual disease, a likely…”
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Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity by Kleczko, Emily K., Hinz, Trista K., Nguyen, Teresa T., Gurule, Natalia J., Navarro, Andre, Le, Anh T., Johnson, Amber M., Kwak, Jeff, Polhac, Diana I., Clambey, Eric T., Weiser-Evans, Mary, Merrick, Daniel T., Yang, Michael C., Patil, Tejas, Schenk, Erin L., Heasley, Lynn E., Nemenoff, Raphael A.

“…Lung cancers bearing oncogenic EML4-ALK fusions respond to targeted tyrosine kinase inhibitors (TKIs; e.g., alectinib), with variation in the degree of…”
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Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis by Gurule, Natalia J., Malcolm, Kenneth C., Harris, Chelsea, Knapp, Jennifer R., O’Connor, Brian P., McClendon, Jazalle, Janssen, William J., Lee, Frank Fang Yao, Price, Caitlin, Osaghae-Nosa, Jackson, Wheeler, Emily A., McMahon, Christine M., Pietras, Eric M., Pollyea, Daniel A., Alper, Scott

“…Myelodysplastic neoplasm (MDS) is a hematopoietic stem cell disorder that may evolve into acute myeloid leukemia. Fatal infection is among the most common…”
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Abstract 2635: Differential inhibition of autophagic pathways in melanoma is oncogene-dependent by White, Kirsten A. M., Torres, Salina M., Thompson, Todd A., Hu, Chien-An A., Gurule, Natalia J., Berwick, Marianne

“…One person dies from melanoma every hour worldwide. The American Cancer Society estimates that in 2013 the 5-year survival rate for stage IV melanoma will…”
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Abstract 2041: Inhibition of autophagy in melanoma: using cell lines to model chloroquine sensitivity by White, Kirsten A., Torres, Salina M., Gurule, Natalia J., Berwick, Marianne, Hu, Chien-An A.

“…Metastatic melanoma offers an ongoing clinical challenge. According to the American Cancer Society, the 5-year survival rate in 2012 for stage IV melanoma is…”
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