Search Results - "Gurtner, Alessandra"

Intestinal eosinophils, homeostasis and response to bacterial intrusion by Gurtner, Alessandra, Gonzalez-Perez, Ignacio, Arnold, Isabelle C.

“…Eosinophils are traditionally considered as end-stage effector cells involved in the pathogenesis of Th2 immune-mediated disorders as well as in the protection…”
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Histone deacetylase inhibitors enhance oncolytic herpes simplex virus therapy for malignant meningioma by Kawamura, Yoichiro, Hua, Lingyang, Gurtner, Alessandra, Wong, Ego, Kiyokawa, Juri, Shah, Nadia, Gorham, Joshua, Wakimoto, Hiroko, Rabkin, Samuel D., Martuza, Robert L., Wakimoto, Hiroaki

“…Approximately 20% of meningiomas are not benign (higher grade) and tend to relapse after surgery and radiation therapy. Malignant (anaplastic) meningioma (MM)…”
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Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells by Borrelli, Costanza, Valenta, Tomas, Handler, Kristina, Vélez, Karelia, Gurtner, Alessandra, Moro, Giulia, Lafzi, Atefeh, Roditi, Laura de Vargas, Hausmann, George, Arnold, Isabelle C., Moor, Andreas E., Basler, Konrad

“…The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of crypt-resident intestinal epithelial stem cells (IESCs)…”
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Emerging functions of tissue-resident eosinophils by Gurtner, Alessandra, Crepaz, Daniel, Arnold, Isabelle C

“…Eosinophils are typically considered tissue-damaging effector cells in type 2 immune-related diseases. However, they are also increasingly recognized as…”
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Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils by Borrelli, Costanza, Gurtner, Alessandra, Arnold, Isabelle C., Moor, Andreas E.

“…Eosinophils are a class of granulocytes with pleiotropic functions in homeostasis and various human diseases. Nevertheless, they are absent from conventional…”
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Active eosinophils regulate host defence and immune responses in colitis by Gurtner, Alessandra, Borrelli, Costanza, Gonzalez-Perez, Ignacio, Bach, Karsten, Acar, Ilhan E., Núñez, Nicolás G., Crepaz, Daniel, Handler, Kristina, Vu, Vivian P., Lafzi, Atefeh, Stirm, Kristin, Raju, Deeksha, Gschwend, Julia, Basler, Konrad, Schneider, Christoph, Slack, Emma, Valenta, Tomas, Becher, Burkhard, Krebs, Philippe, Moor, Andreas E., Arnold, Isabelle C.

“…In the past decade, single-cell transcriptomics has helped to uncover new cell types and states and led to the construction of a cellular compendium of health…”
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The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses by Arnold, Isabelle C, Artola-Boran, Mariela, Gurtner, Alessandra, Bertram, Katrin, Bauer, Michael, Frangez, Ziva, Becher, Burkhard, Kopf, Manfred, Yousefi, Shida, Simon, Hans-Uwe, Tzankov, Alexandar, Müller, Anne

“…The depletion of eosinophils represents an efficient strategy to alleviate allergic asthma, but the consequences of prolonged eosinophil deficiency for human…”
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Extracellular RNAs: A New Awareness of Old Perspectives by Sadik, Noah, Cruz, Lilian, Gurtner, Alessandra, Rodosthenous, Rodosthenis S, Dusoswa, Sophie A, Ziegler, Olivia, Van Solinge, Thomas Sebastiaan, Wei, Zhiyun, Salvador-Garicano, Ane Miren, Gyorgy, Bence, Broekman, Marike, Balaj, Leonora

“…Extracellular RNA (exRNA) has recently expanded as a highly important area of study in biomarker discovery and cancer therapeutics. exRNA consists of diverse…”
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TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin− RORγt+ regulatory T-cells during bacterial and allergen challenge by Fallegger, Angela, Priola, Martina, Artola-Borán, Mariela, Núñez, Nicolás Gonzalo, Wild, Sebastian, Gurtner, Alessandra, Becher, Burkhard, Yousefi, Shida, Simon, Hans-Uwe, Arnold, Isabelle C., Müller, Anne

“…Eosinophils are best known for their effector functions in settings of parasitic infection or allergen challenge, but have also increasingly been implicated in…”
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CSIG-33. BETA 1 INTEGRIN INHIBITION IN HIGH-GRADE MENINGIOMA by Nigim, Fares, Gurtner, Alessandra, Brastianos, Priscilla, Cahill, Daniel, Rabkin, Samuel D, Martuza, Robert L, Carbonell, Shawn, Wakimoto, Hiroaki

“…High-grade meningiomas (HGM, World Health Organization classification grade II and III) have high relapse rates and poor clinical outcomes despite surgery and…”
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A Monoclonal Antibody Against β1 Integrin Inhibits Proliferation and Increases Survival in an Orthotopic Model of High-Grade Meningioma by Nigim, Fares, Kiyokawa, Juri, Gurtner, Alessandra, Kawamura, Yoichiro, Hua, Lingyang, Kasper, Ekkehard M., Brastianos, Priscilla K., Cahill, Daniel P., Rabkin, Samuel D., Martuza, Robert L., Carbonell, W. Shawn, Wakimoto, Hiroaki

“…Background High-grade meningiomas (HGMs; World Health Organization [WHO] classification grade II and III) have high relapse rates and poor clinical outcomes…”
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