Monitoring bone morphogenetic protein-2 and -7, soluble receptor activator of nuclear factor-κB ligand and osteoprotegerin levels in the peri-implant sulcular fluid during the osseointegration of hydrophilic-modified sandblasted acid-etched and sandblasted acid-etched surface dental implants

Background and Objective The implant surface plays a major role in the biological response to titanium dental implants. The aim of this study was to investigate levels of soluble receptor activator of nuclear factor‐κB ligand (sRANKL), osteoprotegerin (OPG), bone morphogenetic protein‐2 (BMP‐2) and...

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Published in:	Journal of periodontal research Vol. 50; no. 1; pp. 62 - 73
Main Authors:	Dolanmaz, D., Saglam, M., Inan, O., Dundar, N., Alniacık, G., Gursoy Trak, B., Kocak, E., Hakki, S. S.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-02-2015
Subjects:	Acid Etching, Dental - methods Adult Bone Morphogenetic Protein 2 - analysis Bone Morphogenetic Protein 7 - analysis bone morphogenetic proteins Dental Etching - methods dental implant Dental Implants Dental Plaque Index Dental Prosthesis Design Dentistry Female Follow-Up Studies Gingival Crevicular Fluid - chemistry Humans Hydrophobic and Hydrophilic Interactions Male Middle Aged Osseointegration - physiology osteoprotegerin Osteoprotegerin - analysis Periodontal Index Periodontal Pocket - classification RANK Ligand - analysis receptor activator of nuclear factor-kappa B Surface Properties receptor activator of nuclear factor-kappa B osteoprotegerin dental implant bone morphogenetic proteins
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Summary:	Background and Objective The implant surface plays a major role in the biological response to titanium dental implants. The aim of this study was to investigate levels of soluble receptor activator of nuclear factor‐κB ligand (sRANKL), osteoprotegerin (OPG), bone morphogenetic protein‐2 (BMP‐2) and ‐7 (BMP‐7) in the peri‐implant crevicular fluid (PICF) of different implants during the osseointegration period. Material and Methods Forty‐seven patients (22 females and 25 males, mean age 47.34 ± 10.11) were included in this study. Forty‐seven implants from two implant systems (group A1 (sandblasted acid‐etched [SLA]‐16), group A2 (hydrophilic‐modified SLA [SLActive]‐16), and group B (sandblasted acid‐etched [SLA]‐15) were placed using standard surgical protocols. PICF samples, plaque index, gingival index and probing depth measurements were obtained at 1 and 3 mo after surgery. PICF levels of sRANKL, OPG, BMP‐2/‐7 were analyzed by ELISA. Results No complications were observed during the healing period. No significant differences were observed in the PICF levels of sRANKL, OPG, BMP‐2 and BMP‐7 for all groups at any time point (p > 0.05). A significant decrease was observed in BMP‐2 levels in group A1 (p < 0.05). A significant increase in BMP‐7 levels was observed only for group A2 (p < 0.05). There was a strong negative correlation between OPG and gingival index and a negative correlation between BMP‐7 and plaque index (p < 0.05). Conclusion Considering the correlations between clinical and biochemical parameters, the levels of these cytokines in PICF during early healing of implants reflects the degree of peri‐implant inflammation, rather than differences in the implant surfaces.
Bibliography:	istex:0832F8C565F2AC9A27BBE7D7D2611575B55B554C Research Project Coordination of Selçuk University - No. 08401093 ark:/67375/WNG-JCXPB6JJ-B ArticleID:JRE12182 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-3484 1600-0765
DOI:	10.1111/jre.12182