Search Results - "Gursky, Jan"

Oxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia by Kapralova, Katarina, Jahoda, Ondrej, Koralkova, Pavla, Gursky, Jan, Lanikova, Lucie, Pospisilova, Dagmar, Divoky, Vladimir, Horvathova, Monika

“…Molecular pathophysiology of Diamond-Blackfan anemia (DBA) involves disrupted erythroid-lineage proliferation, differentiation and apoptosis; with the…”
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Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells by Skolekova, Svetlana, Matuskova, Miroslava, Bohac, Martin, Toro, Lenka, Durinikova, Erika, Tyciakova, Silvia, Demkova, Lucia, Gursky, Jan, Kucerova, Lucia

“…Cells of the tumor microenvironment are recognized as important determinants of the tumor biology. The adjacent non-malignant cells can regulate drug responses…”
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A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment by Chroma, Katarina, Skrott, Zdenek, Gursky, Jan, Bacovsky, Jaroslav, Moudry, Pavel, Buchtova, Tereza, Mistrik, Martin, Bartek, Jiri

“…Despite several approved therapeutic modalities, multiple myeloma (MM) remains an incurable blood malignancy and only a small fraction of patients achieves…”
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Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Dzubak, Petr, Gurský, Ján, Táborská, Natálie, Das, Viswanath, Agrawal, Khushboo, Hajduch, Marian

“…The advanced-stage colon cancer spreads from primary tumor site to distant organs where the colon-unassociated stromal population provides a favorable niche…”
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Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics by Beresova, Lucie, Vesela, Eva, Chamrad, Ivo, Voller, Jiri, Yamada, Masayuki, Furst, Tomas, Lenobel, Rene, Chroma, Katarina, Gursky, Jan, Krizova, Katerina, Mistrik, Martin, Bartek, Jiri

“…Replication stress (RS) fuels genomic instability and cancer development and may contribute to aging, raising the need to identify factors involved in cellular…”
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Newly identified CHO ERCC3/XPB mutations and phenotype characterization by Rybanská, Ivana, Gurský, Ján, Fašková, Miriam, Salazar, Edmund P., Kimlíčková-Polakovičová, Erika, Kleibl, Karol, Thompson, Larry H., Piršel, Miroslav

“…Nucleotide excision repair (NER) is a complex multistage process involving many interacting gene products to repair a wide range of DNA lesions. Genetic…”
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Expression of Jak2 R1063H Leads to Altered Epor/Tpor Signaling, Changes in HSC Fitness and Represents Increased Risk of Thrombosis by Kropackova, Veronika, Gursky, Jan, Balounova, Jana, Korinek, Vladimir, Divoky, Vladimir, Lanikova, Lucie

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Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase by Skrott, Zdenek, Majera, Dusana, Gursky, Jan, Buchtova, Tereza, Hajduch, Marian, Mistrik, Martin, Bartek, Jiri

“…Aldehyde dehydrogenase (ALDH) is a proposed biomarker and possible target to eradicate cancer stem cells. ALDH inhibition as a treatment approach is supported…”
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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 by Skrott, Zdenek, Mistrik, Martin, Andersen, Klaus Kaae, Friis, Søren, Majera, Dusana, Gursky, Jan, Ozdian, Tomas, Bartkova, Jirina, Turi, Zsofia, Moudry, Pavel, Kraus, Marianne, Michalova, Martina, Vaclavkova, Jana, Dzubak, Petr, Vrobel, Ivo, Pouckova, Pavla, Sedlacek, Jindrich, Miklovicova, Andrea, Kutt, Anne, Li, Jing, Mattova, Jana, Driessen, Christoph, Dou, Q. Ping, Olsen, Jørgen, Hajduch, Marian, Cvek, Boris, Deshaies, Raymond J., Bartek, Jiri

“…Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need…”
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CDKN1A Gene Expression in Two Multiple Myeloma Cell Lines With Different P53 Functionality by DROZDKOVA, DENISA HRCKOVA, GURSKY, JAN, MINARIK, JIRI, ÜBERALL, IVO, KOLAR, ZDENEK, TRTKOVA, KATERINA SMESNY

“…Background/Aim: Multiple myeloma is a highly heterogeneous disease of clonal plasma cells. Histone deacetylase (HDAC) inhibitors are promising anticancer drugs…”
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Targeting of SFK and G6PD Contributes to Anti-Leukemic Activity of Novel FLT3 Trisubstituted Purine Inhibitors: Effective Therapeutic Approach for AML with FLT3 Mutations by Koralkova, Pavla, Niederlova, Nikola, Hradilova, Iveta, Gursky, Jan, Cudova, Barbora, Urbankova, Helena, Reznickova, Eva, Gucky, Tomas, Myslivcova, Denisa, Belickova, Monika, Krystof, Vladimir, Divoky, Vladimir

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Imaging flow cytometry as a sensitive tool to detect low‐dose‐induced DNA damage by analyzing 53BP1 and γH2AX foci in human lymphocytes by Durdik, Matus, Kosik, Pavol, Gursky, Jan, Vokalova, Lenka, Markova, Eva, Belyaev, Igor

“…Ionizing radiation induced foci (IRIF) are considered the most sensitive indicator for DNA double‐strand break (DSB) detection. Monitoring DSB induction by low…”
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Disulfiram May Contribute to Apoptosis of Myeloma Cells By Reactivating of Cell Cycle Regulating Gene CDKN2A by Drozdkova, Denisa Hrckova, Gursky, Jan, Luzna, Petra, Sevcikova, Sabina, Minarik, Jiri, Trtkova, Katerina Smesny

“…Objective: Multiple myeloma (MM) is an incurable plasma-cell dyscrasia characterized by uncontrolled growth of malignant plasma cells in the bone marrow…”
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JAK2 V617F Progenitors Utilize Adaptations to Cell-Autonomous and Microenvironment-Dependent Inflammatory Stress in Polycythemia Vera, Likely Exhibiting Barrier Against Rapid Transformation to Myelofibrosis by Stetka, Jan, Luzna, Pavla, Lanikova, Lucie, Koralkova, Pavla, Gursky, Jan, Hodny, Zdenek, Bartek, Jiri, Divoky, Vladimir

“…It has been shown that hyperactivated JAK-STAT signaling axis in oncogenic JAK2 V617F mutation-positive polycythemia vera (PV) leads to dysregulation of…”
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Cells and Stripes: A novel quantitative photo-manipulation technique by Mistrik, Martin, Vesela, Eva, Furst, Tomas, Hanzlikova, Hana, Frydrych, Ivo, Gursky, Jan, Majera, Dusana, Bartek, Jiri

“…Laser micro-irradiation is a technology widely used in the DNA damage response, checkpoint signaling, chromatin remodeling and related research fields, to…”
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Epigenetic modulation of AR gene expression in prostate cancer DU145 cells with the combination of sodium butyrate and 5′-Aza-2′-deoxycytidine by Fialova, Barbora, Luzna, Petra, Gursky, Jan, Langova, Katerina, Kolar, Zdenek, Trtkova, Katerina Smesny

“…The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a…”
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Targeting genotoxic and proteotoxic stress‐response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram by Majera, Dusana, Skrott, Zdenek, Bouchal, Jan, Bartkova, Jirina, Simkova, Dana, Gachechiladze, Mariam, Steigerova, Jana, Kurfurstova, Daniela, Gursky, Jan, Korinkova, Gabriela, Cwiertka, Karel, Hodny, Zdenek, Mistrik, Martin, Bartek, Jiri

“…Background Castration‐resistant prostate cancer (PCa) represents a serious health challenge. Based on mechanistically‐supported rationale we explored new…”
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Abstract 3598: Laser micro-irradiations of large amounts of cells for high content applications by Mistrik, Martin, Vesela, Eva, Furst, Tomas, Frydrych, Ivo, Gursky, Jan, Bartek, Jiri

“…Abstract A new methodical approach for the evaluation of photo-manipulated samples is presented and tested in various biological setups. The method is based on…”
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Abstract 4101: Stromal cell-induced alterations in the response of colorectal cancer cell to demethylating agents by Das, Viswanath, Skolekova, Svetlana, Agrawal, Khushboo, Gursky, Jan, Kučerová, Lucia, Hajdúch, Marián

“…Abstract Epigenetic mechanisms such as DNA hypermethylation, that results in gene silencing, is closely associated with resistance to platinum-based…”
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Stimulating effect of normal-dosing of fibrates on cell proliferation: word of warning by Cizkova, Katerina, Steigerova, Jana, Gursky, Jan, Ehrmann, Jiri

“…Fibrates are widely used hypolipidemic drugs, which serve as ligand of peroxisome proliferator-activated receptor α (PPARα). Recently, they have also been…”
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