Search Results - "Gurská, Soňa"

Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX by Grüner, Bohumír, Brynda, Jiří, Das, Viswanath, Šícha, Václav, Štěpánková, Jana, Nekvinda, Jan, Holub, Josef, Pospíšilová, Klára, Fábry, Milan, Pachl, Petr, Král, Vlastimil, Kugler, Michael, Mašek, Vlastimil, Medvedíková, Martina, Matějková, Stanislava, Nová, Alice, Lišková, Barbora, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Řezáčová, Pavlína

“…Carbonic anhydrase IX (CAIX) is a transmembrane enzyme that regulates pH in hypoxic tumors and promotes tumor cell survival. Its expression is associated with…”
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Synthesis of Polycyclic Hetero-Fused 7‑Deazapurine Heterocycles and Nucleosides through C–H Dibenzothiophenation and Negishi Coupling by Yang, Chao, Slavětínská, Lenka Poštová, Fleuti, Marianne, Klepetářová, Blanka, Tichý, Michal, Gurská, Soňa, Pavliš, Petr, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

“…A new approach for synthesizing polycyclic heterofused 7-deazapurine heterocycles and the corresponding nucleosides was developed based on C–H…”
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Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7‑Deazapurine Ribonucleosides by Tichý, Michal, Smoleń, Sabina, Tloušt’ová, Eva, Pohl, Radek, Oždian, Tomáš, Hejtmánková, Klára, Lišková, Barbora, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

“…Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno­[2′,3′:4,5]­pyrrolo­[2,3-d]­pyrimidines and…”
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Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity by Vrzalová, Aneta, Pečinková, Petra, Illés, Peter, Gurská, Soňa, Džubák, Petr, Szotkowski, Martin, Hajdúch, Marián, Mani, Sridhar, Dvořák, Zdeněk

“…Aryl hydrocarbon receptor (AHR) plays pivotal roles in intestinal physiology and pathophysiology. Intestinal AHR is activated by numerous dietary, endogenous,…”
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Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid by Borková, Lucie, Frydrych, Ivo, Jakubcová, Nikola, Adámek, Richard, Lišková, Barbora, Gurská, Soňa, Medvedíková, Martina, Hajdúch, Marián, Urban, Milan

“…In this work, 35 new derivatives of betulonic, dihydrobetulonic and ursonic acid were prepared including 30 aminothiazoles and all of them were tested for…”
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AminoBODIPY Conjugates for Targeted Drug Delivery Systems and Real-Time Monitoring of Drug Release by Porubský, Martin, Gurská, Soňa, Stanková, Jarmila, Hajdúch, Marián, Džubák, Petr, Hlaváč, Jan

“…In this work, we report two concepts of drug delivery based on small-molecule drug conjugates with the ability of specific targeting and drug release…”
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Synthesis and Biological Profiling of Pyrazolo-Fused 7‑Deazapurine Nucleosides by Fleuti, Marianne, Bártová, Kateřina, Slavětínská, Lenka Poštová, Tloušt’ová, Eva, Tichý, Michal, Gurská, Soňa, Pavliš, Petr, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

“…A series of 8-substituted 1-methyl-1,4-dihydropyrazolo­[3′,4′:4,5]­pyrrolo­[2,3-d]­pyrimidine (methylpyrazolo-fused 7-deazapurine) ribonucleosides have been…”
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Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7‑Deazapurine Ribonucleosides by Tokarenko, Anna, Lišková, Barbora, Smoleń, Sabina, Táborská, Natálie, Tichý, Michal, Gurská, Soňa, Perlíková, Pavla, Frydrych, Ivo, Tloušt’ová, Eva, Znojek, Pawel, Mertlíková-Kaiserová, Helena, Poštová Slavětínská, Lenka, Pohl, Radek, Klepetářová, Blanka, Khalid, Noor-Ul-Ain, Wenren, Yiqian, Laposa, Rebecca R, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

“…Three series of isomeric pyrrolo- and furo-fused 7-deazapurine ribonucleosides were synthesized and screened for cytostatic and antiviral activity. The…”
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Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation by Řehulka, Jiří, Jurášek, Michal, Dráber, Pavel, Ivanová, Aleksandra, Gurská, Soňa, Ječmeňová, Kateřina, Mokshyna, Olena, Hajdúch, Marián, Polishchuk, Pavel, Drašar, Pavel B, Džubák, Petr

“…Estradiol dimers (EDs) possess significant anticancer activity by targeting tubulin dynamics. In this study, we synthesised 12 EDs variants via…”
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Synthesis and Biological Evaluation of Oxindole Sulfonamide Derivatives as Bruton's Tyrosine Kinase Inhibitors by Koraboina, Chandra Prakash, Maddipati, Venkatanarayana Chowdary, Annadurai, Narendran, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Das, Viswanath, Gundla, Rambabu

“…Bruton's tyrosine kinase (BTK) is a promising molecular target for several human B‐cell‐related autoimmune disorders, inflammation, and haematological…”
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Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells – Synthesis, potency, and mitochondrial mechanism of action by Kazakova, Anna, Frydrych, Ivo, Jakubcová, Nikola, Pokorný, Jan, Lišková, Barbora, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Urban, Milan

“…A series of triterpenoid pyrones was synthesized and subsequently modified to introduce phthalimide or phthalate moieties into the triterpenoid skeleton. These…”
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Synthesis and Biological Profiling of Benzofuro‐Fused 7‐Deazapurine Nucleosides by Yang, Chao, Tichý, Michal, Poštová Slavětínská, Lenka, Vaiedelich, Enzo, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

“…A series of benzofuro‐fused 7‐deazapurine (6H‐furo[2,3‐e]pyrimido[4,5‐b]indole) 2’‐deoxyribo‐ and ribonucleosides was designed and synthesized. The synthesis…”
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Synthesis, Photophysical Properties, and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides by Yang, Chao, Pohl, Radek, Tichý, Michal, Gurská, Soňa, Pavliš, Petr, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

“…Two isomeric series of benzothieno-fused 7-deazapurine (benzo[4',5']thieno[3',2':4,5]- and benzo[4',5']thieno[2',3':4,5]pyrrolo[2,3- ]pyrimidine)…”
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Synthesis and Biological Profiling of Quinolino-Fused 7‑Deazapurine Nucleosides by Fleuti, Marianne, Sanchez-Quirante, Tania, Poštová Slavětínská, Lenka, Tloušt'ová, Eva, Tichý, Michal, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Hocek, Michal

“…A series of quinolino-fused 7-deazapurine (pyrimido­[5′,4′:4,5]­pyrrolo­[3,2-f]­quinoline) ribonucleosides were designed and synthesized. The synthesis of the…”
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Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes by Borková, Lucie, Frydrych, Ivo, Vránová, Barbora, Jakubcová, Nikola, Lišková, Barbora, Gurská, Soňa, Džubák, Petr, Pavliš, Petr, Hajdúch, Marián, Urban, Milan

“…In this work, a large set of betulinic acid derivatives modified with various aromatic substituents at the position C-3 were prepared via Suzuki-Myiaura…”
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Estradiol dimer inhibits tubulin polymerization and microtubule dynamics by Jurášek, Michal, Černohorská, Markéta, Řehulka, Jiří, Spiwok, Vojtěch, Sulimenko, Tetyana, Dráberová, Eduarda, Darmostuk, Maria, Gurská, Soňa, Frydrych, Ivo, Buriánová, Renata, Ruml, Tomáš, Hajdúch, Marián, Bartůněk, Petr, Dráber, Pavel, Džubák, Petr, Drašar, Pavel B., Sedlák, David

“…[Display omitted] •Estradiol dimer inhibits tubulin assembly in vitro.•Estradiol dimer reversibly disrupts microtubule structures in U2OS cells.•Estradiol…”
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Novel 5‑Substituted Oxindole Derivatives as Bruton’s Tyrosine Kinase Inhibitors: Design, Synthesis, Docking, Molecular Dynamics Simulation, and Biological Evaluation by Velavalapalli, Vani Madhuri, Maddipati, Venkatanarayana Chowdary, Gurská, Soňa, Annadurai, Narendran, Lišková, Barbora, Katari, Naresh Kumar, Džubák, Petr, Hajdúch, Marián, Das, Viswanath, Gundla, Rambabu

“…Bruton’s tyrosine kinase (BTK) is a non-RTK cytoplasmic kinase predominantly expressed by hemopoietic lineages, particularly B-cells. A new oxindole-based…”
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C‐5 Aryl Substituted Azaspirooxindolinones Derivatives: Synthesis and Biological Evaluation as Potential Inhibitors of Tec Family Kinases by Mudasani, Gopal, Paidikondala, Kalyani, Gurská, Soňa, Maddirala, Shambabu Joseph, Džubák, Petr, Das, Viswanath, Gundla, Rambabu

“…The interleukin‐2‐inducible kinase (ITK) and Bruton tyrosine kinase (BTK) are two crucial Tec family kinase members with important roles in the development of…”
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Substituted dienes prepared from betulinic acid – Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters by Pokorný, Jan, Olejníková, Denisa, Frydrych, Ivo, Lišková, Barbora, Gurská, Soňa, Benická, Sandra, Šarek, Jan, Kotulová, Jana, Hajdúch, Marián, Džubák, Petr, Urban, Milan

“…A set of new substituted dienes were synthesized from betulinic acid by its oxidation to 30-oxobetulinic acid followed by the Wittig reaction. Cytotoxicity of…”
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Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2 H )-one Derivatives by Blanco, Zuleima, Fernandez-Moreira, Esteban, Mijares, Michael R, Celis, Carmen, Martínez, Gricelis, De Sanctis, Juan B, Gurská, Soňa, Džubák, Petr, Hajdůch, Marián, Mijoba, Ali, García, Yael, Serrano, Xenón, Herrera, Nahum, Correa-Abril, Jhonny, Parra, Yonathan, Ángel, Jorge, Ramírez, Hegira, Charris, Jaime E

“…The coexistence of leishmaniasis, Chagas disease, and neoplasia in endemic areas has been extensively documented. The use of common drugs in the treatment of…”
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