Search Results - "Gurniak, Christine"

The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair by Kuo, Wei-Ting, Zuo, Li, Odenwald, Matthew A., Madha, Shariq, Singh, Gurminder, Gurniak, Christine B., Abraham, Clara, Turner, Jerrold R.

“…Increased permeability is implicated in the pathogenesis of intestinal disease. In vitro and in vivo studies have linked down-regulation of the scaffolding…”
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ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS by Tedeschi, Andrea, Dupraz, Sebastian, Curcio, Michele, Laskowski, Claudia J., Schaffran, Barbara, Flynn, Kevin C., Santos, Telma E., Stern, Sina, Hilton, Brett J., Larson, Molly J.E., Gurniak, Christine B., Witke, Walter, Bradke, Frank

“…Injured axons fail to regenerate in the adult CNS, which contrasts with their vigorous growth during embryonic development. We explored the potential of…”
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Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure by Escuin, Sarah, Vernay, Bertrand, Savery, Dawn, Gurniak, Christine B, Witke, Walter, Greene, Nicholas D E, Copp, Andrew J

“…The cytoskeleton is widely considered essential for neurulation, yet the mouse spinal neural tube can close despite genetic and non-genetic disruption of the…”
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Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission by Rehklau, Katharina, Hoffmann, Lena, Gurniak, Christine B, Ott, Martin, Witke, Walter, Scorrano, Luca, Culmsee, Carsten, Rust, Marco B

“…Mitochondria form highly dynamic networks in which organelles constantly fuse and divide. The relevance of mitochondrial dynamics is evident from its…”
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ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival by Kanellos, Georgios, Zhou, Jing, Patel, Hitesh, Ridgway, Rachel A., Huels, David, Gurniak, Christine B., Sandilands, Emma, Carragher, Neil O., Sansom, Owen J., Witke, Walter, Brunton, Valerie G., Frame, Margaret C.

“…Genetic co-depletion of the actin-severing proteins ADF and CFL1 triggers catastrophic loss of adult homeostasis in multiple tissues. There is impaired…”
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ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis by Wolf, Michael, Zimmermann, Anika-Maria, Görlich, Andreas, Gurniak, Christine B, Sassoè-Pognetto, Marco, Friauf, Eckhard, Witke, Walter, Rust, Marco B

“…Actin is a regulator of synaptic vesicle mobilization and exocytosis, but little is known about the mechanisms that regulate actin at presynaptic terminals…”
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Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics by Rust, Marco B, Gurniak, Christine B, Renner, Marianne, Vara, Hugo, Morando, Laura, Görlich, Andreas, Sassoè-Pognetto, Marco, Banchaabouchi, Mumna Al, Giustetto, Maurizio, Triller, Antoine, Choquet, Daniel, Witke, Walter

“…Neuronal plasticity is an important process for learning, memory and complex behaviour. Rapid remodelling of the actin cytoskeleton in the postsynaptic…”
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N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex by Bellenchi, Gian Carlo, Gurniak, Christine B, Perlas, Emerald, Middei, Silvia, Ammassari-Teule, Martine, Witke, Walter

“…Many neuronal disorders such as lissencephaly, epilepsy, and schizophrenia are caused by the abnormal migration of neurons in the developing brain. The role of…”
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Cell injury triggers actin polymerization to initiate epithelial restitution by Aihara, Eitaro, Medina-Candelaria, Neisha M, Hanyu, Hikaru, Matthis, Andrea L, Engevik, Kristen A, Gurniak, Christine B, Witke, Walter, Turner, Jerrold R, Zhang, Tongli, Montrose, Marshall H

“…The role of the actin cytoskeleton in the sequence of physiological epithelial repair in the intact epithelium has yet to be elucidated. Here, we explore the…”
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Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models by Megaw, Roly, Abu-Arafeh, Hashem, Jungnickel, Melissa, Mellough, Carla, Gurniak, Christine, Witke, Walter, Zhang, Wei, Khanna, Hemant, Mill, Pleasantine, Dhillon, Baljean, Wright, Alan F., Lako, Majlinda, ffrench-Constant, Charles

“…Mutations in the Retinitis Pigmentosa GTPase Regulator ( RPGR ) cause X-linked RP (XLRP), an untreatable, inherited retinal dystrophy that leads to premature…”
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Attention-Deficit/Hyperactivity Disorder–like Phenotype in a Mouse Model with Impaired Actin Dynamics by Zimmermann, Anika-Maria, Jene, Tanja, Wolf, Michael, Görlich, Andreas, Gurniak, Christine B, Sassoè-Pognetto, Marco, Witke, Walter, Friauf, Eckhard, Rust, Marco B

“…Abstract Background Actin depolymerizing proteins of the actin depolymerizing factor (ADF)/cofilin family are essential for actin dynamics, which is critical…”
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The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration by Gurniak, Christine B., Perlas, Emerald, Witke, Walter

“…Cofilin/ADF proteins are a ubiquitously expressed family of F-actin depolymerizing factors found in eukaryotic cells including plants. In vitro, cofilin/ADF…”
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Ciliary tip actin dynamics regulate photoreceptor outer segment integrity by Megaw, Roly, Moye, Abigail, Zhang, Zhixian, Newton, Fay, McPhie, Fraser, Murphy, Laura C., McKie, Lisa, He, Feng, Jungnickel, Melissa K., von Kriegsheim, Alex, Tennant, Peter A., Brotherton, Chloe, Gurniak, Christine, Gross, Alecia K., Machesky, Laura M., Wensel, Theodore G., Mill, Pleasantine

“…As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter…”
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Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF by Jönsson, Friederike, Gurniak, Christine B, Fleischer, Bernhard, Kirfel, Gregor, Witke, Walter

“…Dynamic changes in the actin cytoskeleton are essential for immune cell function and a number of immune deficiencies have been linked to mutations, which…”
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ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain by Flynn, Kevin C., Hellal, Farida, Neukirchen, Dorothee, Jacob, Sonja, Tahirovic, Sabina, Dupraz, Sebastian, Stern, Sina, Garvalov, Boyan K., Gurniak, Christine, Shaw, Alisa E., Meyn, Liane, Wedlich-Söldner, Roland, Bamburg, James R., Small, J. Victor, Witke, Walter, Bradke, Frank

“…Neurites are the characteristic structural element of neurons that will initiate brain connectivity and elaborate information. Early in development, neurons…”
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N-cofilin can compensate for the loss of ADF in excitatory synapses by Görlich, Andreas, Wolf, Michael, Zimmermann, Anika-Maria, Gurniak, Christine B, Al Banchaabouchi, Mumna, Sassoè-Pognetto, Marco, Witke, Walter, Friauf, Eckhard, Rust, Marco B

“…Actin plays important roles in a number of synaptic processes, including synaptic vesicle organization and exocytosis, mobility of postsynaptic receptors, and…”
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Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance by Gurniak, Christine B., Chevessier, Frédéric, Jokwitz, Melanie, Jönsson, Friederike, Perlas, Emerald, Richter, Hendrik, Matern, Gabi, Boyl, Pietro Pilo, Chaponnier, Christine, Fürst, Dieter, Schröder, Rolf, Witke, Walter

“…Mutations in the human actin depolymerizing factor cofilin2 result in an autosomal dominant form of nemaline myopathy. Here, we report on the targeted ablation…”
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Actin-depolymerizing Factor Cofilin-1 Is Necessary in Maintaining Mature Podocyte Architecture by Garg, Puneet, Verma, Rakesh, Cook, Leslie, Soofi, Abdul, Venkatareddy, Madhusudan, George, Britta, Mizuno, Kensaku, Gurniak, Christine, Witke, Walter, Holzman, Lawrence B.

“…Actin dynamics determines podocyte morphology during development and in response to podocyte injury and might be necessary for maintaining normal podocyte…”
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Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons by Kullmann, Jan A, Neumeyer, Alexander, Gurniak, Christine B, Friauf, Eckhard, Witke, Walter, Rust, Marco B

“…Cerebellar granule neurons (CGNs) exploit Bergmann glia (BG) fibres for radial migration, and cell–cell contacts have a pivotal role in this process…”
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ADF/n-cofilin–dependent actin turnover determines platelet formation and sizing by Bender, Markus, Eckly, Anita, Hartwig, John H., Elvers, Margitta, Pleines, Irina, Gupta, Shuchi, Krohne, Georg, Jeanclos, Elisabeth, Gohla, Antje, Gurniak, Christine, Gachet, Christian, Witke, Walter, Nieswandt, Bernhard

“…The cellular and molecular mechanisms orchestrating the complex process by which bone marrow megakaryocytes form and release platelets remain poorly…”
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