Search Results - "Gurney, AL"

Regulation of Thrombopoietin Levels by c-mpl–Mediated Binding to Platelets by Fielder, Paul J., Gurney, Austin L., Stefanich, Eric, Marian, Melinda, Moore, Mark W., Carver-Moore, Karen, Sauvage, Frederic J. de

“…The involvement of platelets and the c-mpl receptor in the regulation of thrombopoietin (TPO) plasma concentrations and tissue mRNA levels was investigated in…”
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IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes by Boniface, Katia, Bernard, Francois-Xavier, Garcia, Martine, Gurney, Austin L, Lecron, Jean-Claude, Morel, Franck

“…IL-22 belongs to a family of cytokines structurally related to IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast to IL-10, IL-22 has proinflammatory…”
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Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17 by Aggarwal, Sudeepta, Ghilardi, Nico, Xie, Ming-Hong, de Sauvage, Frederic J., Gurney, Austin L.

“…Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells. Despite increasing evidence that high levels of IL-17 are associated…”
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IL-17: prototype member of an emerging cytokine family by Aggarwal, Sudeepta, Gurney, Austin L.

“…IL‐17 is a potent proinflammatory cytokine produced by activated memory T cells. The large‐scale sequencing of the human and other vertebrate genomes has…”
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IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues by Gurney, Austin L

“…IL-22, also termed IL-TIF, is a member of the IL-10 family of cytokines. Its principal source appears to be memory CD4 T cells with a Th1 polarized phenotype…”
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novel form of resistance in rice to the angiosperm parasite Striga hermonthica by Gurney, A.L, Slate, J, Press, M.C, Scholes, J.D

“…• The root hemiparasitic weed Striga hermonthica is a serious constraint to grain production of economically important cereals in sub-Saharan Africa. Breeding…”
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Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice by Ghilardi, Nico, Kljavin, Noelyn, Chen, Qi, Lucas, Sophie, Gurney, Austin L, de Sauvage, Frederic J

“…The heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a cytokine receptor-like subunit, p40, which is shared with IL-12…”
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IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding by Hymowitz, Sarah G., Filvaroff, Ellen H., Yin, JianPing, Lee, James, Cai, Liping, Risser, Philip, Maruoka, Miko, Mao, Weiguang, Foster, Jessica, Kelley, Robert F., Pan, Guohua, Gurney, Austin L., de Vos, Abraham M., Starovasnik, Melissa A.

“…The proinflammatory cytokine interleukin 17 (IL‐17) is the founding member of a family of secreted proteins that elicit potent cellular responses. We report a…”
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Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R by Xie, Ming-Hong, Aggarwal, Sudeepta, Ho, Wei-Hsien, Foster, Jessica, Zhang, Zemin, Stinson, Jeremy, Wood, William I., Goddard, Audrey D., Gurney, Austin L.

“…We report the identification of a novel human cytokine, distantly related to interleukin (IL)-10, which we term IL-22. IL-22 is produced by activated T cells…”
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The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment by Clark, Hilary F, Gurney, Austin L, Abaya, Evangeline, Baker, Kevin, Baldwin, Daryl, Brush, Jennifer, Chen, Jian, Chow, Bernard, Chui, Clarissa, Crowley, Craig, Currell, Bridget, Deuel, Bethanne, Dowd, Patrick, Eaton, Dan, Foster, Jessica, Grimaldi, Christopher, Gu, Qimin, Hass, Philip E, Heldens, Sherry, Huang, Arthur, Kim, Hok Seon, Klimowski, Laura, Jin, Yisheng, Johnson, Stephanie, Lee, James, Lewis, Lhney, Liao, Dongzhou, Mark, Melanie, Robbie, Edward, Sanchez, Celina, Schoenfeld, Jill, Seshagiri, Somasekar, Simmons, Laura, Singh, Jennifer, Smith, Victoria, Stinson, Jeremy, Vagts, Alicia, Vandlen, Richard, Watanabe, Colin, Wieand, David, Woods, Kathryn, Xie, Ming-Hong, Yansura, Daniel, Yi, Sothy, Yu, Guoying, Yuan, Jean, Zhang, Min, Zhang, Zemin, Goddard, Audrey, Wood, William I, Godowski, Paul, Gray, Alane

“…A large-scale effort, termed the Secreted Protein Discovery Initiative (SPDI), was undertaken to identify novel secreted and transmembrane proteins. In the…”
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Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling by Godowski, Paul J, Yang, Ruey-Bing, Mark, Melanie R, Gray, Alane, Huang, Arthur, Xie, Ming Hong, Zhang, Min, Goddard, Audrey, Wood, William I, Gurney, Austin L

“…Vertebrates and invertebrates initiate a series of defence mechanisms following infection by Gram-negative bacteria by sensing the presence of…”
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Genomic Structure, Chromosomal Localization, and Conserved Alternative Splice Forms of Thrombopoietin by Gurney, Austin L., Kuang, Wun-Jing, Xie, Ming-Hong, Malloy, Beth E., Eaton, Dan L., de Sauvage, Frederic J.

“…Thrombopoietin (TPO), the ligand for c-mpl, is a novel cytokine comprising an amino terminal domain with homology to erythropoietin and a glycosylated carboxyl…”
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IL-17E, a Novel Proinflammatory Ligand for the IL-17 Receptor Homolog IL-17Rh1 by Lee, James, Ho, Wei-Hsien, Maruoka, Miko, Corpuz, Racquel T., Baldwin, Daryl T., Foster, Jessica S., Goddard, Audrey D., Yansura, Daniel G., Vandlen, Richard L., Wood, William I., Gurney, Austin L.

“…We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein…”
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Cloning and Characterization of IL-17B and IL-17C, Two New Members of the IL-17 Cytokine Family by Li, Hanzhong, Chen, Jian, Huang, Arthur, Stinson, Jeremy, Heldens, Sherry, Foster, Jessica, Dowd, Patrick, Gurney, Austin L., Wood, William I.

“…IL-17 is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Whereas expression of…”
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Identification of Synergistic Signals Initiating Inner Ear Development by Ladher, Raj K., Anakwe, Kelly U., Gurney, Austin L., Schoenwolf, Gary C., Francis-West, Philippa H.

“…Tissue manipulation experiments in amphibians more than 50 years ago showed that induction of the inner ear requires two signals: a mesodermal signal followed…”
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Forced Expression of Murine IL-17E Induces Growth Retardation, Jaundice, a Th2-Biased Response, and Multiorgan Inflammation in Mice by Pan, Guohua, French, Dorothy, Mao, Weiguang, Maruoka, Miko, Risser, Philip, Lee, James, Foster, Jessica, Aggarwal, Sudeepta, Nicholes, Katrina, Guillet, Susan, Schow, Peter, Gurney, Austin L

“…IL-17 is a proinflammatory cytokine, and its in vivo expression induces neutrophilia in mice. IL-17E is a recently described member of an emerging family of…”
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WISP Genes are Members of the Connective Tissue Growth Factor Family that are Up-Regulated in Wnt-1-Transformed Cells and Aberrantly Expressed in Human Colon Tumors by Pennica, Diane, Swanson, Todd A., Welsh, James W., Roy, Margaret A., Lawrence, David A., Lee, James, Brush, Jennifer, Taneyhill, Lisa A., Deuel, Bethanne, Lew, Michael, Watanabe, Colin, Cohen, Robert L., Melhem, Mona F., Finley, Gene G., Quirke, Phil, Goddard, Audrey D., Hillan, Kenneth J., Gurney, Austin L., Botstein, David, Levine, Arnold J.

“…Wnt family members are critical to many developmental processes, and components of the Wnt signaling pathway have been linked to tumorigenesis in familial and…”
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Signaling Events Induced by Lipopolysaccharide-Activated Toll-Like Receptor 2 by Yang, Ruey-Bing, Mark, Melanie R, Gurney, Austin L, Godowski, Paul J

“…Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates NF-kappaB. Here, we investigate further the events triggered by…”
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Novel sources of resistance to Striga hermonthica in Tripsacum dactyloides, a wild relative of maize by Gurney, A.L, Grimanelli, D, Kanampiu, F, Hoisington, H, Scholes, J.D, Press, M.C

“…• The parasitic weed Striga hermonthica lowers cereal yield in small-holder farms in Africa. Complete resistance in maize to S. hermonthica infection has not…”
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FGF-19, A NOVEL FIBROBLAST GROWTH FACTOR WITH UNIQUE SPECIFICITY FOR FGFR4 by Xie, Ming-Hong, Holcomb, Ilona, Deuel, Bethanne, Dowd, Patrick, Huang, Arthur, Vagts, Alicia, Foster, Jessica, Liang, Jie, Brush, Jennifer, Gu, Qimin, Hillan, Kenneth, Goddard, Audrey, Gurney, Austin L.

“…We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin…”
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