Search Results - "Gurling, Hugh M."

A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder by McQuillin, Andrew, Rizig, Mie, Gurling, Hugh M.D

“…OBJECTIVESLithium is the most widely prescribed and effective mood-stabilizing drug used for the treatment of bipolar affective disorder. To understand how…”
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Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1 by Xu, Wei, Cohen-Woods, Sarah, Chen, Qian, Noor, Abdul, Knight, Jo, Hosang, Georgina, Parikh, Sagar V, De Luca, Vincenzo, Tozzi, Federica, Muglia, Pierandrea, Forte, Julia, McQuillin, Andrew, Hu, Pingzhao, Gurling, Hugh M D, Kennedy, James L, McGuffin, Peter, Farmer, Anne, Strauss, John, Vincent, John B

“…Recently, genome-wide association studies (GWAS) for cases versus controls using single nucleotide polymorphism microarray data have shown promising findings…”
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Genetic association, mutation screening, and functional analysis of a Kozak sequence variant in the metabotropic glutamate receptor 3 gene in bipolar disorder by Kandaswamy, Radhika, McQuillin, Andrew, Sharp, Sally I, Fiorentino, Alessia, Anjorin, Adebayo, Blizard, Robert A, Curtis, David, Gurling, Hugh M D

“…Genetic markers at the gene encoding the metabotropic glutamate receptor 3 (GRM3) showed allelic association with bipolar disorder. To screen the GRM3 gene and…”
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Genetics of attention-deficit hyperactivity disorder (ADHD) by Sharp, Sally I., McQuillin, Andrew, Gurling, Hugh M.D.

“…Attention-deficit hyperactivity disorder (ADHD) is a clinically and genetically heterogeneous syndrome which is comorbid with childhood conduct disorder,…”
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Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome by Sharp, Sally I., McQuillin, Andrew, Marks, Michael, Hunt, Stephen P., Stanford, S. Clare, Lydall, Greg J., Morgan, Marsha Y., Asherson, Philip, Curtis, David, Gurling, Hugh M. D.

“…Single nucleotide polymorphisms (SNPs) in the tachykinin receptor 1 gene (TACR1) are nominally associated with bipolar affective disorder (BPAD) in a…”
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Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder by Pereira, Ana C. Parente, McQuillin, Andrew, Puri, Vinay, Anjorin, Adebayo, Bass, Nicholas, Kandaswamy, Radhika, Lawrence, Jacob, Curtis, David, Sklar, Pamela, Purcell, Shaun M., Gurling, Hugh M.D.

“…Insulin‐like growth factor 1 (IGF1) has been shown to have an important role in brain development and function. Studies of IGF1 administration in rodents have…”
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Three-dimensional textural analysis of brain images reveals distributed grey-matter abnormalities in schizophrenia by Ganeshan, Balaji, Miles, Kenneth A., Young, Rupert C. D., Chatwin, Christopher R., Gurling, Hugh M. D., Critchley, Hugo D.

“…Objectives Three-dimensional (3-D) selective- and relative-scale texture analysis (TA) was applied to structural magnetic resonance (MR) brain images to…”
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Molecular and genomic studies of IMMP2L and mutation screening in autism and Tourette syndrome by Petek, Erwin, Schwarzbraun, Thomas, Noor, Abdul, Patel, Megha, Nakabayashi, Kazuhiko, Choufani, Sanaa, Windpassinger, Christian, Stamenkovic, Mara, Robertson, Mary M, Aschauer, Harald N, Gurling, Hugh M. D, Kroisel, Peter M, Wagner, Klaus, Scherer, Stephen W, Vincent, John B

“…We recently reported the disruption of the inner mitochondrial membrane peptidase 2-like (IMMP2L) gene by a chromosomal breakpoint in a patient with Gilles de…”
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Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population by Way, Michael, McQuillin, Andrew, Saini, Jit, Ruparelia, Kush, Lydall, Gregory J., Guerrini, Irene, Ball, David, Smith, Iain, Quadri, Giorgia, Thomson, Allan D., Kasiakogia-Worlley, Katherine, Cherian, Raquin, Gunwardena, Priyanthi, Rao, Harish, Kottalgi, Girija, Patel, Shamir, Hillman, Audrey, Douglas, Ewen, Qureshi, Sherhzad Y., Reynolds, Gerry, Jauhar, Sameer, O'Kane, Aideen, Dedman, Alex, Sharp, Sally, Kandaswamy, Radhika, Dar, Karim, Curtis, David, Morgan, Marsha Y., Gurling, Hugh M. D.

“…Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol…”
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Genetic variant analysis of the putative regulatory regions of the LRRC7 gene in bipolar disorder by Fiorentino, Alessia, Sharp, Sally I, Kandaswamy, Radhika, Gurling, Hugh M D, Bass, Nicholas J, McQuillin, Andrew

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Support of association between BRD1 and both schizophrenia and bipolar affective disorder by Nyegaard, Mette, Severinsen, Jacob E., Als, Thomas D., Hedemand, Anne, Straarup, Steen, Nordentoft, Merete, McQuillin, Andrew, Bass, Nicholas, Lawrence, Jacob, Thirumalai, Srinivasa, Pereira, Ana C.P., Kandaswamy, Radhika, Lydall, Gregory J., Sklar, Pamela, Scolnick, Edward, Purcell, Shaun, Curtis, David, Gurling, Hugh M.D., Mortensen, Preben B., Mors, Ole, Børglum, Anders D.

“…A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and…”
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The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis by Sharp, Sally I, Hu, Ying, Weymer, Jon F, Rizig, Mie, McQuillin, Andrew, Hunt, Stephen P, Gurling, Hugh M.D

“…OBJECTIVESClathrin-mediated endocytosis (CME) is an intracellular trafficking mechanism for packaging cargo, including G protein-coupled receptors (GPCRs),…”
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A Genetic Association Study of Chromosome 11q22-24 in Two Different Samples Implicates the FXYD6 Gene, Encoding Phosphohippolin, in Susceptibility to Schizophrenia by Choudhury, Khalid, McQuillin, Andrew, Puri, Vinay, Pimm, Jonathan, Datta, Susmita, Thirumalai, Srinivasa, Krasucki, Robert, Lawrence, Jacob, Bass, Nicholas J., Quested, Digby, Crombie, Caroline, Fraser, Gillian, Walker, Nicholas, Nadeem, Haitham, Johnson, Sophie, Curtis, David, St. Clair, David, Gurling, Hugh M.D.

“…Previous linkage analyses of families with multiple cases of schizophrenia by us and others have confirmed the involvement of the chromosome 11q22-24 region in…”
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Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition by Anstee, Quentin M., Knapp, Susanne, Maguire, Edward P., Hosie, Alastair M., Thomas, Philip, Mortensen, Martin, Bhome, Rohan, Martinez, Alonso, Walker, Sophie E., Dixon, Claire I., Ruparelia, Kush, Montagnese, Sara, Kuo, Yu-Ting, Herlihy, Amy, Bell, Jimmy D., Robinson, Iain, Guerrini, Irene, McQuillin, Andrew, Fisher, Elizabeth M.C., Ungless, Mark A., Gurling, Hugh M.D., Morgan, Marsha Y., Brown, Steve D.M., Stephens, David N., Belelli, Delia, Lambert, Jeremy J., Smart, Trevor G., Thomas, Howard C.

“…Alcohol dependence is a common, complex and debilitating disorder with genetic and environmental influences. Here we show that alcohol consumption increases…”
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Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder by Rajkumar, Anto P, Christensen, Jane H, Mattheisen, Manuel, Jacobsen, Iben, Bache, Iben, Pallesen, Jonatan, Grove, Jakob, Qvist, Per, McQuillin, Andrew, Gurling, Hugh M, Tümer, Zeynep, Mors, Ole, Børglum, Anders D

“…Objectives Breakpoints of chromosomal abnormalities facilitate identification of novel candidate genes for psychiatric disorders. Genome‐wide significant…”
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A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia by Rizig, Mie A, McQuillin, Andrew, Ng, Aylwin, Robinson, Michelle, Harrison, Andrew, Zvelebil, Marketa, Hunt, Steve P, Gurling, Hugh M

“…Clozapine has markedly superior clinical properties compared to other antipsychotic drugs but the side effects of agranulocytosis, weight gain and diabetes…”
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Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes by Curtis, David, Vine, Anna E, McQuillin, Andrew, Bass, Nicholas James, Pereira, Ana, Kandaswamy, Radhika, Lawrence, Jacob, Anjorin, Adebayo, Choudhury, Khalid, Datta, Susmita R, Puri, Vinay, Krasucki, Robert, Pimm, Jonathan, Thirumalai, Srinivasa, Quested, Digby, Gurling, Hugh M D

“…There are theoretical reasons why comparing marker allele frequencies between cases of different diseases, rather than with controls, may offer benefits. The…”
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A nonconservative amino acid change in the UPF3B gene in a patient with schizophrenia by Szyszka, Paulina, Sharp, Sally I, Dedman, Alexandra, Gurling, Hugh M D, McQuillin, Andrew

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Molecular Genetics of Alcohol-Related Brain Damage by Guerrini, Irene, Thomson, Allan D., Gurling, Hugh M.

“…Aims: In the scientific literature it has been repeatedly hypothesized that there is a heritable susceptibility to thiamine deficiency comparable to other…”
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Mosaic copy number variation in schizophrenia by Ruderfer, Douglas M, Chambert, Kim, Moran, Jennifer, Talkowski, Michael, Chen, Elizabeth S, Gigek, Carolina, Gusella, James F, Blackwood, Douglas H, Corvin, Aiden, Gurling, Hugh M, Hultman, Christina M, Kirov, George, Magnusson, Patrick, O'Donovan, Michael C, Owen, Michael J, Pato, Carlos, St Clair, David, Sullivan, Patrick F, Purcell, Shaun M, Sklar, Pamela, Ernst, Carl

“…Recent reports suggest that somatic structural changes occur in the human genome, but how these genomic alterations might contribute to disease is unknown…”
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