Search Results - "Gurley, KE"

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer by Westcott, Peter M. K., Halliwill, Kyle D., To, Minh D., Rashid, Mamunur, Rust, Alistair G., Keane, Thomas M., Delrosario, Reyno, Jen, Kuang-Yu, Gurley, Kay E., Kemp, Christopher J., Fredlund, Erik, Quigley, David A., Adams, David J., Balmain, Allan

“…Whole-exome sequencing is used to compare the mutational landscape of adenomas from three mouse models of non-small-cell lung cancer, induced either by…”
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Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer by Xu, Chang, Nikolova, Olga, Basom, Ryan S, Mitchell, Ryan M, Shaw, Reid, Moser, Russell D, Park, Heuijoon, Gurley, Kay E, Kao, Michael C, Green, Carlos L, Schaub, Franz X, Diaz, Robert L, Swan, Hallie A, Jang, In S, Guinney, Justin, Gadi, Vijayakrishna K, Margolin, Adam A, Grandori, Carla, Kemp, Christopher J, Méndez, Eduardo

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with high mortality and a lack of targeted therapies. To identify and…”
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Distinct roles for p53, p27 , and p21 during tumor development

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Deficiency in the gap junction protein Connexin32 alters p27 tumor suppression and MAPK activation in a tissue-specific manner

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Pathway-specific tumor suppression: Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice by Philipp-Staheli, Jeannette, Kim, Kyung-Hoon, Payne, Shannon R, Gurley, Kay E, Liggitt, Denny, Longton, Gary, Kemp, Christopher J

“…Expression of the cyclin-dependent kinase inhibitor p27 Kip1 (p27) is frequently reduced in human colorectal cancer, and this correlates with poor patient…”
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Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of K-ras driven lung cancer by Kelly-Spratt, KS, Philipp-Staheli, J, Gurley, KE, Hoon-Kim, K, Knoblaugh, S, Kemp, CJ

“…Reduced expression of the CDK inhibitor p27 Kip1 (p27) in human lung cancer correlates with tumour aggressiveness and poor prognosis. However, the regulation…”
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p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent by KEMP, Christopher J, SHAOLI SUN, GURLEY, Kay E

“…The p53 protein rapidly accumulates in cells in response to DNA damage, which can trigger apoptosis. This pathway is hypothesized to be important for tumor…”
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Synthetic lethality between mutation in Atm and DNA-PK sub(cs) during murine embryogenesis by Gurley, KE, Kemp, C J

“…The gene product mutated in ataxia telangiectasia, ATM, is a ubiquitously expressed 370 kDa protein kinase that is a key mediator of the cellular response to…”
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Proteome and transcriptome profiles of a Her2/Neu-driven mouse model of breast cancer by Schoenherr, Regine M., Kelly-Spratt, Karen S., Lin, ChenWei, Whiteaker, Jeffrey R., Liu, Tao, Holzman, Ted, Coleman, Ilsa, Feng, Li-Chia, Lorentzen, Travis D., Krasnoselsky, Alexei L., Wang, Pei, Liu, Yan, Gurley, Kay E., Amon, Lynn M., Schepmoes, Athena A., Moore, Ronald J., Camp II, David G., Chodosh, Lewis A., Smith, Richard D., Nelson, Peter S., McIntosh, Martin W., Kemp, Christopher J., Paulovich, Amanda G.

“…Purpose: We generated extensive transcriptional and proteomic profiles from a Her2‐driven mouse model of breast cancer that closely recapitulates human breast…”
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Deficiency in the gap junction protein Connexin32 alters p27 super(Kip1) tumor suppression and MAPK activation in a tissue-specific manner by King, T J, Gurley, KE, Prunty, J, Shin, J-L, Kemp, C J, Lampe, P D

“…Connexin32 knockout mice (Cx32-KO) exhibit increased chemical- and radiation-induced liver and lung tumor formation with many lung tumors demonstrating…”
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Distinct roles for p53, p27 super(Kip1), and p21 super(Cip1) during tumor development by Philipp-Staheli, J, Kim, K-H, Liggitt, D, Gurley, KE, Longton, G, Kemp, C J

“…Mutations in p53 and reduced expression of the Cdk inhibitor p27 super(Kip1) are frequently observed in a wide variety of human cancers, but it is not known…”
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p53 induction, cell cycle checkpoints, and apoptosis in DNAPK- deficient scid mice by Gurley, Kay E., Kemp, Christopher J.

“…The p53 tumor suppressor protein is rapidly induced following treatment of cells with agents which cause DNA double strand breaks (dsbs) leading to cell cycle…”
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Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody by Nicolls, M R, Aversa, G G, Pearce, N W, Spinelli, A, Berger, M F, Gurley, K E, Hall, B M

“…Monoclonal antibodies to CD3 have been shown to activate T cells in vivo and in vitro but have also been shown to render T cells anergic in vitro. In this…”
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DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice by GURLEY, K. E, KHOA VO, KEMP, C. J

“…The tumor-suppressing phenotype of p53 is thought to be due to its accumulation in response to DNA damage and resultant cell cycle arrest or apoptosis…”
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Pathway-specific tumor suppression: Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Min/+ mutant mice by Philipp-Staheli, J, Kim, K-H, Payne, SR, Gurley, KE, Liggitt, D, Longton, G, Kemp, C J

“…Expression of the cyclin-dependent kinase inhibitor p27 super(Kip1) (p27) is frequently reduced in human colorectal cancer, and this correlates with poor…”
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Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis by Kemp, Christopher J., Vo, Khoa, Gurley, Kay E.

“…Scid/scid mice have a mutation in the gene encoding the catalytic subunit of DNA-dependent protein kinase (DNAPKcs) and are defective in end joining of DNA…”
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Tumor suppression by p27 super(Kip1) and p super(Cip1) during chemically induced skin carcinogenesis by Philipp, J, Vo, K, Gurley, KE, Seidel, K, Kemp, C J

“…p27 super(Kip1) and p21 super(Cip1) are cyclin dependent kinase inhibitors which can arrest cell proliferation and p27 is a tumor suppressor gene. To address…”
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The murine gene p27 super(Kip1) is haplo-insufficient for tumour suppression by Fero, M L, Randel, E, Gurley, KE, Roberts, J M, Kemp, C J

“…p27 super(Kip) is a candidate human tumour-suppressor protein, because it is able to inhibit cyclin-dependent kinases and block cell proliferation. Abnormally…”
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Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells by Hall, B M, Jelbart, M E, Gurley, K E, Dorsch, S E

“…DA rats grafted with major histocompatibility complex-incompatible PVG heart grafts and treated with cyclosporine (CY) for 10 d do not reject their grafts, and…”
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Cellular basis of allograft rejection in vivo. V. Examination of the mechanisms responsible for the differing efficacy of monoclonal antibody to CD4+ T cell subsets in low- and high-responder rat strains by Ilano, AL, McConnell, MV, Gurley, KE, Spinelli, A, Pearce, NW, Hall, BM

“…MRC OX35, an anti-CD4 mAb, was used to treat high responder Wistar Furth (W/F) (RT1u) and low responder DA (RT1a) rats which had been grafted with directly…”
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