Search Results - "Gurley, K E"

p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent by KEMP, Christopher J, SHAOLI SUN, GURLEY, Kay E

“…The p53 protein rapidly accumulates in cells in response to DNA damage, which can trigger apoptosis. This pathway is hypothesized to be important for tumor…”
Get full text

ARF inhibits the growth and malignant progression of non-small-cell lung carcinoma by Busch, S E, Moser, R D, Gurley, K E, Kelly-Spratt, K S, Liggitt, H D, Kemp, C J

“…Non-small-cell lung carcinoma (NSCLC) is among the deadliest of human cancers. The CDKN2A locus, which houses the INK4a and ARF tumor suppressor genes, is…”
Get full text

p53 induction, cell cycle checkpoints, and apoptosis in DNAPK- deficient scid mice by Gurley, Kay E., Kemp, Christopher J.

“…The p53 tumor suppressor protein is rapidly induced following treatment of cells with agents which cause DNA double strand breaks (dsbs) leading to cell cycle…”
Get full text

Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody by Nicolls, M R, Aversa, G G, Pearce, N W, Spinelli, A, Berger, M F, Gurley, K E, Hall, B M

“…Monoclonal antibodies to CD3 have been shown to activate T cells in vivo and in vitro but have also been shown to render T cells anergic in vitro. In this…”
Get more information

DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice by GURLEY, K. E, KHOA VO, KEMP, C. J

“…The tumor-suppressing phenotype of p53 is thought to be due to its accumulation in response to DNA damage and resultant cell cycle arrest or apoptosis…”
Get full text

Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis by Kemp, Christopher J., Vo, Khoa, Gurley, Kay E.

“…Scid/scid mice have a mutation in the gene encoding the catalytic subunit of DNA-dependent protein kinase (DNAPKcs) and are defective in end joining of DNA…”
Get full text

Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer by Kelly-Spratt, K S, Philipp-Staheli, J, Gurley, K E, Hoon-Kim, K, Knoblaugh, S, Kemp, C J

“…Reduced expression of the CDK inhibitor p27 Kip1 (p27) in human lung cancer correlates with tumor aggressiveness and poor prognosis. However, the regulation of…”
Get full text

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III: Further characterization of the CD4+ suppressor cell and its mechanisms of action by HALL, B. M, PEARCE, N. W, GURLEY, K. E, DORSCH, S. E

“…The cellular basis of the specific unresponsiveness that develops in DA rats treated with cyclosporine (CSA) for 10 d after grafting a PVG heart was examined…”
Get full text

Cellular basis of allograft rejection in vivo. V. Examination of the mechanisms responsible for the differing efficacy of monoclonal antibody to CD4+ T cell subsets in low- and high-responder rat strains by Ilano, AL, McConnell, MV, Gurley, KE, Spinelli, A, Pearce, NW, Hall, BM

“…MRC OX35, an anti-CD4 mAb, was used to treat high responder Wistar Furth (W/F) (RT1u) and low responder DA (RT1a) rats which had been grafted with directly…”
Get full text

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. VI. In vitro alloreactivity of T cell subsets from rats with long-surviving allografts by Pearce, N W, Berger, M F, Gurley, K E, Spinelli, A, Hall, B M

“…DA rats treated with a short course of cyclosporine develop specific unresponsiveness to RT1-incompatible PVG donor heart allografts. CD4+ cells, not CD8+…”
Get more information

Induction of tolerance to heart allografts in rats using posttransplant total lymphoid irradiation and anti-T cell antibodies by Woodley, S L, Gurley, K E, Hoffmann, S L, Nicolls, M R, Hagberg, R, Clayberger, C, Holm, B, Wang, X, Hall, B M, Strober, S

“…This study examined whether posttransplant anti-T cell monoclonal or polyclonal antibody therapy could provide a window of treatment to allow posttransplant…”
Get more information

Mechanisms maintaining antibody-induced enhancement of allografts. II. Mediation of specific suppression by short lived CD4+ T cells by Pearce, NW, Spinelli, A, Gurley, KE, Dorsch, SE, Hall, BM

“…In DA rats grafted with PVG hearts, the injection of 1 ml of Wistar-Furth x DA)F1 anti-PVG serum on the day of grafting prevents rejection and induces a state…”
Get full text

Immune mechanisms in organ allograft rejection. I. Delayed-type hypersensitivity and lymphocytotoxicity in heart graft rejection by Lowry, R P, Gurley, K E, Forbes, R D

“…Sublethally irradiated (780 rads) rats receiving fully allogeneic heart transplants were reconstituted with sensitized lymphocytes fractionated into helper and…”
Get more information

The possible role of cytotoxic T cells in the mediation of first-set allograft rejection by Hall, B M, Gurley, K E, Dorsch, S E

Get more information

Immune mechanisms in organ allograft rejection. II. T helper cells, delayed-type hypersensitivity, and rejection of renal allografts by Gurley, K E, Lowry, R P, Forbes, R D

“…The cellular requirements for renal allograft rejection have been assessed by adoptive transfer studies in a rat model. Sublethally irradiated (780 rads) LEW…”
Get more information

Inhibition of PI-3K restores nuclear p27 expression in a mouse model of Kras-driven lung cancer

Get full text

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. II. Sequential changes in alloreactivity of T cell subsets by Hall, B M, Gurley, K E, Pearce, N W, Dorsch, S E

“…A 10-day course of cyclosporine treatment inhibits the capacity of DA rats to reject PVG heart grafts and leads to the development of specific unresponsiveness…”
Get more information

The murine gene p27Kip1 is haplo-insufficient for tumour suppression by FERO, M. L, RANDEL, E, GURLEY, K. E, ROBERTS, J. M, KEMP, C. J

“…p27Kip is a candidate human tumour-suppressor protein, because it is able to inhibit cyclin-dependent kinases and block cell proliferation. Abnormally low…”
Get full text

Tempo of induction of W3/25+ suppressor cells in cyclosporine-treated rat cardiac allograft recipients by Hall, B M, Gurley, K E, Dorsch, S E

Get more information

"The factor of immunization" in allograft rejection: carried by cytotoxic T cells, not helper-inducer T cells by Gurley, K E, Hall, B M, Dorsch, S E

Get more information