Topical prebiotics/postbiotics and PRURISCORE validation in atopic dermatitis. International study of 396 patients

Aim: To investigate the efficacy and tolerability of a cream (Rilastil Xerolact PB) containing a mixture of prebiotics and postbiotics, and to validate the PRURISCORE itch scale in the management of atopic dermatitis. Methods: The study is based on 396 subjects of both sexes in three age groups (i.e...

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Published in:	The Journal of dermatological treatment Vol. 34; no. 1; p. 2131703
Main Authors:	Gelmetti, Carlo, Rigoni, Corinna, Cantù, Alessandra Maria, Agolzer, Antonina, Agrusa, Alice, Brena, Michela, Dall'Oglio, Federica, Demichelis, Patrizia, Farina, Sandra, Frasin, Lucretia Adina, Lorenzi, Sandra, Mazzola, Giuseppina, Praticò, Marisa, Robotti, Stefania, Tedeschi, Aurora, Villa, Lucia, Ananiadis, Prodromos, Arkoumani, Eirini, Astashonok, Iulia, Baselga Torres, Eulalia, Borici, Sidita, Cano, Elna, Cela, Rozana, Cengo, Amarda, Corella, Francisca, Cubiro Raventos, Xavier, De Jesus Silva, Miriam America, Demiraj, Ermira, Dhima, Entela, Doci, Xhiljola, Domarad, Anna, Didyk, Marina, Dyli, Albana, Efthimiou, Ourania, Filippi, Georgia, Flores Climente, Víctor-Adrian, Garcia Muret, Maria Pilar, Navarro, Javier Garcia, Gega, Migena, Giakoub, Aristea Noura, Giakoubis, Vasileios, Gica, Amarda, Gjomema, Marjeta, Guri, Blerina, Janushaj, Elmijola, Kanelleas, Antonios, Kanelopoulou, Georgia, Kapaj, Entela, Kapoukranidou, Dorothea, Karadima, Konstantina, Katsavou, Athina, Kotrulja, Lena, Kyriakou, Aikaterini, Larios, Georgios, Lopez, Anna, Lopez, Cristina, Manoli, Sofia Magdalini, Matvienko, Tatiana, Mervic, Liljana, Mileounis, Konstantinos, Muja, Diana, Nadezhda, Milkota, Panagioti, Despoina, Papakonstantis, Markos, Papanikou, Maria, Papathemeli, Despoina, Papigkioti, Kyriaki, Pivak, Violetta, Preza, Driada, Roé, Esther, Rogl Butina, Mirjam, Serra Baldrich, Esther, Sgouros, Dimitrios, Shilova, Aleksandra, Shllaku, Eljona, Sideris, Nikolaos, Sina, Ermal, Sinani, Ardiana, Sourli-Chasioti, Fani, Stankaj, Mirsa, Tasioula, Dimitra, Tsalmadoupis, Athanasios, Tsatsou, Fragkiski, Tsenebi, Eftichia, Tsitlakidou, Anastasia, Vassis, Politimos, Vilarrassa, Eva, Vorobey, Olga, Voutsakis, Nikolaos, Yakovleva, Svetlana, Yakubovskaya, Svetlana, Yerygina, Ekaterina, Zarras, Alexios, Zenelaj, Valbona, Zenko, Olga
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 31-12-2023 Taylor & Francis Group
Subjects:	Adult Atopic dermatitis Child Dermatitis, Atopic - drug therapy Emollients Female Humans Infant Male postbiotics Prebiotics Probiotics - therapeutic use PRURISCORE Pruritus Quality of Life Severity of Illness Index Quality of Life prebiotics postbiotics PRURISCORE Atopic dermatitis
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Summary:	Aim: To investigate the efficacy and tolerability of a cream (Rilastil Xerolact PB) containing a mixture of prebiotics and postbiotics, and to validate the PRURISCORE itch scale in the management of atopic dermatitis. Methods: The study is based on 396 subjects of both sexes in three age groups (i.e., infants, children, adults) suffering from mild/moderate Atopic Dermatitis, recruited from 8 European countries and followed for 3 months. Results: The product demonstrated good efficacy combined with good/very good tolerability in all age groups. In particular, SCORAD, PRURISCORE and IGA scores decreased significantly over the course of the study. The PRURISCORE was preferred to VAS by the vast majority of patients. Conclusion: Even though the role of prebiotics and postbiotics was not formally demonstrated since these substances were part of a complex formulation, it can be reasonably stated that prebiotics and postbiotics have safety and standardization features that probiotics do not have. In addition they are authorized by regulatory authorities, whereas topical probiotics are not.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0954-6634 1471-1753
DOI:	10.1080/09546634.2022.2131703