Search Results - "Gupte, Sachin A."

G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall by Signoretti, Christina, Gupte, Sachin A

“…Recent advances have revealed the importance of epigenetic modifications to gene regulation and transcriptional activity. DNA methylation, a determinant of…”
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G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation by Hashimoto, Ryota, Gupte, Sachin A.

“…Metabolic reprogramming-driven inflammation is emerging as central processes in the pathogenesis of pulmonary hypertension (PH). Although extensive work is…”
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Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming by D'Alessandro, Angelo, El Kasmi, Karim C, Plecitá-Hlavatá, Lydie, Ježek, Petr, Li, Min, Zhang, Hui, Gupte, Sachin A, Stenmark, Kurt R

“…The molecular events that promote the development of pulmonary hypertension (PH) are complex and incompletely understood. The complex interplay between the…”
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Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia by Kitagawa, Atsushi, Jacob, Christina, Jordan, Allan, Waddell, Ian, McMurtry, Ivan F, Gupte, Sachin A

“…Pulmonary hypertension (PH) is a disease of hyperplasia of pulmonary vascular cells. The pentose phosphate pathway (PPP)-a fundamental glucose metabolism…”
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MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension by Joshi, Sachindra Raj, Dhagia, Vidhi, Gairhe, Salina, Edwards, John G, McMurtry, Ivan F, Gupte, Sachin A

“…Heart failure, a major cause of morbidity and mortality in patients with pulmonary arterial hypertension (PAH), is an outcome of complex biochemical processes…”
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Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension by Chettimada, Sukrutha, Gupte, Rakhee, Rawat, Dhwajbahadur, Gebb, Sarah A, McMurtry, Ivan F, Gupte, Sachin A

“…Severe pulmonary hypertension is a debilitating disease with an alarmingly low 5-yr life expectancy. Hypoxia, one of the causes of pulmonary hypertension,…”
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Increased Reactive Oxygen Species, Metabolic Maladaptation, and Autophagy Contribute to Pulmonary Arterial Hypertension–Induced Ventricular Hypertrophy and Diastolic Heart Failure by Rawat, Dhawjbahadur K, Alzoubi, Abdallah, Gupte, Rakhee, Chettimada, Sukrutha, Watanabe, Makino, Kahn, Andrea G, Okada, Takao, McMurtry, Ivan F, Gupte, Sachin A

“…Pulmonary arterial hypertension (PAH) is a debilitating and deadly disease with no known cure. Heart failure is a major comorbidity and a common cause of the…”
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Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation by Joshi, Sachindra Raj, Kitagawa, Atsushi, Jacob, Christina, Hashimoto, Ryota, Dhagia, Vidhi, Ramesh, Amrit, Zheng, Connie, Zhang, Hui, Jordan, Allan, Waddell, Ian, Leopold, Jane, Hu, Cheng-Jun, McMurtry, Ivan F, D'Alessandro, Angelo, Stenmark, Kurt R, Gupte, Sachin A

“…Metabolic reprogramming is considered important in the pathogenesis of the occlusive vasculopathy observed in pulmonary hypertension (PH). However, the…”
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Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell by Kitagawa, Atsushi, Jacob, Christina, Gupte, Sachin A.

“…Although hypoxia induces aberrant gene expression and dedifferentiation of smooth muscle cells (SMCs), mechanisms that alter dedifferentiation gene expression…”
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Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease by Hecker, Peter A, Leopold, Jane A, Gupte, Sachin A, Recchia, Fabio A, Stanley, William C

“…Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the pentose phosphate pathway and produces NADPH to fuel glutathione recycling…”
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CRISPR-Cas9–Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin—Brief Report by Lyu, Qing, Dhagia, Vidhi, Han, Yu, Guo, Bing, Wines-Samuelson, Mary E, Christie, Christine K, Yin, Qiangzong, Slivano, Orazio J, Herring, Paul, Long, Xiaochun, Gupte, Sachin A, Miano, Joseph M

“…OBJECTIVE—Unreliable antibodies often hinder the accurate detection of an endogenous protein, and this is particularly true for the cardiac and smooth muscle…”
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G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease by Signoretti, Christina, Matsumura, Shun, Fatehi, Samuel, D'Silva, Melinee, Mathew, Rajamma, Cendali, Francesca, D'Alessandro, Angelo, Alam, S M Shafiqul, Garcia, Victor, Miano, Joseph M, Gupte, Sachin A

“…G6PD (glucose-6-phosphate-dehydrogenase) is a key enzyme in the glycolytic pathway and has been implicated in the pathogenesis of cancer and pulmonary…”
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Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH by Serpillon, Sabrina, Floyd, Beverly C, Gupte, Rakhee S, George, Shimran, Kozicky, Mark, Neito, Venessa, Recchia, Fabio, Stanley, William, Wolin, Michael S, Gupte, Sachin A

“…Increased oxidative stress is a known cause of cardiac dysfunction in animals and patients with diabetes, but the sources of reactive oxygen species [e.g.,…”
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Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency by Chettimada, Sukrutha, Joshi, Sachindra Raj, Dhagia, Vidhi, Aiezza, 2nd, Alessandro, Lincoln, Thomas M, Gupte, Rakhee, Miano, Joseph M, Gupte, Sachin A

“…Homeostatic control of vascular smooth muscle cell (VSMC) differentiation is critical for contractile activity and regulation of blood flow. Recently, we…”
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Contractile protein expression is upregulated by reactive oxygen species in aorta of Goto-Kakizaki rat by Chettimada, Sukrutha, Ata, Hirotaka, Rawat, Dhwajbahadur K, Gulati, Salil, Kahn, Andrea G, Edwards, John G, Gupte, Sachin A

“…Although it is known that blood vessels undergo remodeling in type 2 diabetes (T2D), the signaling pathways that underlie the structural and functional changes…”
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Poly(ethylene glycol)-cholesterol inhibits L-type Ca2+ channel currents and augments voltage-dependent inactivation in A7r5 cells by Ochi, Rikuo, Chettimada, Sukrutha, Gupte, Sachin A

“…Cholesterol distributes at a high density in the membrane lipid raft and modulates ion channel currents. Poly(ethylene glycol) cholesteryl ether…”
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Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH by Wolin, Michael S, Ahmad, Mansoor, Gupte, Sachin A

“…Vascular smooth muscle (VSM) derived from pulmonary arteries generally contract to hypoxia, whereas VSM from systemic arteries usually relax, indicating the…”
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Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver by Gupte, Rakhee S., Floyd, Beverly C., Kozicky, Mark, George, Shimran, Ungvari, Zoltan I., Neito, Vanessa, Wolin, Michael S., Gupte, Sachin A.

“…Glucose metabolism through the glycolysis and hexosamine pathway has been shown to be altered in type 2 diabetes. However, the fate of glucose through the…”
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Differences in the expression of DNA methyltransferases and demethylases in leukocytes and the severity of pulmonary arterial hypertension between ethnic groups by D’Addario, Catherine A., Lanier, Gregg M., Jacob, Christina, Bauer, Natalie, Hewes, Jenny L., Bhadra, Aritra, Gupte, Sachin A.

“…The loss of ten‐eleven translocation (TET2) methylcytosine dioxygenase expression contributes to the pathobiology of pulmonary arterial hypertension (PAH)…”
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Oxidant and redox signaling in vascular oxygen sensing: implications for systemic and pulmonary hypertension by Gupte, Sachin A, Wolin, Michael S

“…It has been well known for >100 years that systemic blood vessels dilate in response to decreases in oxygen tension (hypoxia; low PO2), and this response…”
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