Search Results - "Gupte, Melanie J."
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Pore size directs bone marrow stromal cell fate and tissue regeneration in nanofibrous macroporous scaffolds by mediating vascularization
Published in Acta biomaterialia (01-12-2018)“…[Display omitted] In the U.S., 30% of adults suffer joint pain, most commonly in the knee, which severely limits mobility and is often attributed to injury of…”
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Nanofibrous Spongy Microspheres Enhance Odontogenic Differentiation of Human Dental Pulp Stem Cells
Published in Advanced healthcare materials (01-09-2015)“…Dentin regeneration is challenging due to its complicated anatomical structure and the shortage of odontoblasts. In this study, a novel injectable cell…”
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3
Effects of hypoxias and scaffold architecture on rabbit mesenchymal stem cell differentiation towards a nucleus pulposus-like phenotype
Published in Biomaterials (01-11-2011)“…Abstract Nucleus pulposus grafts are needed for patients requiring replacement of their degenerated intervertebral discs. Bone marrow-derived mesenchymal stem…”
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4
Development of Channeled Nanofibrous Scaffolds for Oriented Tissue Engineering
Published in Macromolecular bioscience (01-06-2012)“…A tissue‐engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are…”
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Injectable Peptide Decorated Functional Nanofibrous Hollow Microspheres to Direct Stem Cell Differentiation and Tissue Regeneration
Published in Advanced functional materials (21-01-2015)“…Injectable microspheres are attractive stem cell carriers for minimally invasive procedures. For tissue regeneration, the microspheres need to present the…”
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Three-Dimensional Electrodeposition of Calcium Phosphates on Porous Nanofibrous Scaffolds and Their Controlled Release of Calcium for Bone Regeneration
Published in ACS applied materials & interfaces (22-07-2020)“…To mimic the bone matrix of mineralized collagen and to impart microporous structure to facilitate cell migration and bone regeneration, we developed a…”
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Gene therapy for nucleus pulposus regeneration by heme oxygenase-1 plasmid DNA carried by mixed polyplex micelles with thermo-responsive heterogeneous coronas
Published in Biomaterials (01-06-2015)“…Abstract Safe and high-efficiency gene therapy for nucleus pulposus (NP) regeneration was urgently desired to treat disc degeneration-associated diseases. In…”
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Biomaterials and stem cells for tissue engineering
Published in Expert opinion on biological therapy (01-04-2013)“…Organ failure and tissue loss are challenging health issues due to widespread injury, the lack of organs for transplantation and limitations of conventional…”
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Hypoxia promotes nucleus pulposus phenotype in 3D scaffolds in vitro and in vivo: laboratory investigation
Published in Journal of neurosurgery. Spine (01-08-2014)“…The role of oxygen in disc metabolism remains a matter of debate. Whether the effect of hypoxic priming on the nucleus pulposus phenotype can be maintained in…”
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10
Regenerating nucleus pulposus of the intervertebral disc using biodegradable nanofibrous polymer scaffolds
Published in Tissue engineering. Part A (01-11-2012)“…Low back pain is a leading health problem in the United States, which is most often resulted from nucleus pulposus (NP) degeneration. To date, the replacement…”
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Stem Cells: Injectable Peptide Decorated Functional Nanofibrous Hollow Microspheres to Direct Stem Cell Differentiation and Tissue Regeneration (Adv. Funct. Mater. 3/2015)
Published in Advanced functional materials (01-01-2015)“…P. X. Ma and colleagues report the novel functional nanofibrous hollow microspheres (FNF‐HMS) for tissue regeneration on page 350. Peptide decorated FNF‐HMS…”
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12
Effects of Hypoxia and Scaffold Architecture on Rabbit Mesenchymal Stem Cell Differentiation towards a Nucleus Pulposus-like Phenotype
Published in Biomaterials (11-08-2011)“…Nucleus pulposus grafts are needed for patients requiring replacement of their degenerated intervertebral discs. Bone marrow-derived mesenchymal stem cells…”
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Journal Article -
13
Macromol. Biosci. 6/2012
Published in Macromolecular bioscience (01-06-2012)Get full text
Journal Article -
14
Scaffold Pore Size and Calcium Phosphate Coating Control Chondrogenesis and Endochondral Ossification
Published 01-01-2015“…In the United States, 30% of adults suffer joint pain, most commonly in the knee. Knee pain can severely limit mobility and can often be contributed to injury…”
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Dissertation