Search Results - "Gupta, Sunetra"
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1
Mastering malaria: What helps and what hurts
Published in Proceedings of the National Academy of Sciences - PNAS (10-03-2015)Get full text
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Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions
Published in PLoS medicine (01-07-2013)“…The global burden of sickle cell anaemia (SCA) is set to rise as a consequence of improved survival in high-prevalence low- and middle-income countries and…”
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High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi
Published in Nature communications (06-05-2020)“…There are concerns that pneumococcal conjugate vaccines (PCVs) in sub-Saharan Africa sub-optimally interrupt Streptococcus pneumoniae vaccine-serotype (VT)…”
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Modelling the transmission dynamics of H9N2 avian influenza viruses in a live bird market
Published in Nature communications (01-05-2024)“…H9N2 avian influenza viruses (AIVs) are a major concern for the poultry sector and human health in countries where this subtype is endemic. By fitting a model…”
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The roles of competition and mutation in shaping antigenic and genetic diversity in influenza
Published in PLoS pathogens (01-01-2013)“…Influenza A (H3N2) offers a well-studied, yet not fully understood, disease in terms of the interactions between pathogen population dynamics, epidemiology and…”
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Global migration and the changing distribution of sickle haemoglobin: a quantitative study of temporal trends between 1960 and 2000
Published in The Lancet global health (01-02-2014)“…Summary Background Changes in the geographical distribution of genetic disorders are often thought to happen slowly, especially when compared with infectious…”
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Shifting patterns of dengue three years after Zika virus emergence in Brazil
Published in Nature communications (20-01-2024)“…In 2015, the Zika virus (ZIKV) emerged in Brazil, leading to widespread outbreaks in Latin America. Following this, many countries in these regions reported a…”
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Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis
Published in PLoS medicine (01-04-2020)“…International Sustainable Development Goals (SDGs) for elimination of hepatitis B virus (HBV) infection set ambitious targets for 2030. In African populations,…”
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EPINEST, an agent-based model to simulate epidemic dynamics in large-scale poultry production and distribution networks
Published in PLoS computational biology (01-02-2024)“…The rapid intensification of poultry production raises important concerns about the associated risks of zoonotic infections. Here, we introduce EPINEST…”
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The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi
Published in Nature communications (17-11-2023)“…Streptococcus pneumoniae causes substantial mortality among children under 5-years-old worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective…”
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Immunological serotype interactions and their effect on the epidemiological pattern of dengue
Published in Proceedings of the Royal Society. B, Biological sciences (22-07-2009)“…Long-term epidemiological data reveal multi-annual fluctuations in the incidence of dengue fever and dengue haemorrhagic fever, as well as complex cyclical…”
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Quantifying the contribution of Plasmodium falciparum malaria to febrile illness amongst African children
Published in eLife (16-10-2017)“…Suspected malaria cases in Africa increasingly receive a rapid diagnostic test (RDT) before antimalarials are prescribed. While this ensures efficient use of…”
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Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of COVID-19
Published in BMC medicine (12-01-2021)“…Cross-reactivity to SARS-CoV-2 from exposure to endemic human coronaviruses (eHCoV) is gaining increasing attention as a possible driver of both protection…”
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A naturally protective epitope of limited variability as an influenza vaccine target
Published in Nature communications (21-09-2018)“…Current antigenic targets for influenza vaccine development are either highly immunogenic epitopes of high variability or conserved epitopes of low…”
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Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae
Published in PLoS pathogens (01-07-2015)“…The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate…”
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Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern
Published in PLoS pathogens (01-03-2011)“…Many pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the human malaria…”
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Larger mammalian body size leads to lower retroviral activity
Published in PLoS pathogens (01-07-2014)“…Retroviruses have been infecting mammals for at least 100 million years, leaving descendants in host genomes known as endogenous retroviruses (ERVs). The…”
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Pathogen selection drives nonoverlapping associations between HLA loci
Published in Proceedings of the National Academy of Sciences - PNAS (26-11-2013)“…Pathogen-mediated selection is commonly invoked as an explanation for the exceptional polymorphism of the HLA gene cluster, but its role in generating and…”
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Real-time seroprevalence and exposure levels of emerging pathogens in infection-naive host populations
Published in Scientific reports (12-03-2021)“…For endemic pathogens, seroprevalence mimics overall exposure and is minimally influenced by the time that recent infections take to seroconvert. Simulating…”
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Malaria hospitalisation in East Africa: age, phenotype and transmission intensity
Published in BMC medicine (27-01-2022)“…Understanding the age patterns of disease is necessary to target interventions to maximise cost-effective impact. New malaria chemoprevention and vaccine…”
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