Search Results - "Gupta, Smiti V."

A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription by Liu, Mengying, Saha, Nirmalya, Gajan, Ambikai, Saadat, Nadia, Gupta, Smiti V., Pile, Lori A.

“…The SIN3 histone-modifying complex regulates the expression of multiple methionine catabolic genes, including SAM synthetase (Sam-S), as well as SAM levels. To…”
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Potential Role of Garcinol as an Anticancer Agent by Saadat, Nadia, Gupta, Smiti Vaid

“…Garcinol, a polyisoprenylated benzophenone, is extracted from the rind of the fruit of Garcinia indica, a plant found extensively in tropical regions. Although…”
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Metabolomics connects aberrant bioenergetic, transmethylation, and gut microbiota in sarcoidosis by Geamanu, Andreea, Gupta, Smiti V., Bauerfeld, Christian, Samavati, Lobelia

“…Sarcoidosis is a systemic granulomatous disease of unknown etiology. Granulomatous inflammation in sarcoidosis may affect multiple organs, including the lungs,…”
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Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells by Ji, Xiangming, Wang, Zhiwei, Geamanu, Andreea, Goja, Arvind, Sarkar, Fazlul H, Gupta, Smiti V.

“…MicroRNAs (miRNAs) are small noncoding RNAs that play critical roles in regulating various cellular functions by transcriptional silencing. miRNAs can function…”
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Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation by Ji, Xiangming, Wang, Zhiwei, Geamanu, Andreea, Sarkar, Fazlul H, Gupta, Smiti V

“…Lung cancer is the leading cause of death among all cancers. Non‐small cell lung cancer accounts for 80% of lung cancer with a 5‐year survival rate of 16%…”
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Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures by Parasramka, Mansi A., Ali, Shadan, Banerjee, Sanjeev, Deryavoush, Tara, Sarkar, Fazlul H, Gupta, SmitiV

“…Background Alterations in microRNA (miRNA/miR) genes are of biological importance in the pathophysiology of cancers, including pancreatic cancer (PaCa)…”
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Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function by Raja, Vaishnavi, Salsaa, Michael, Joshi, Amit S., Li, Yiran, van Roermund, Carlo W.T., Saadat, Nadia, Lazcano, Pablo, Schmidtke, Michael, Hüttemann, Maik, Gupta, Smiti V., Wanders, Ronald J.A., Greenberg, Miriam L.

“…Previous studies have shown that the cardiolipin (CL)-deficient yeast mutant, crd1Δ, has decreased levels of acetyl-CoA and decreased activities of the TCA…”
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Oil palm phenolics (OPP) inhibit pancreatic cancer cell proliferation via suppression of NF-κB pathway by Ji, Xiangming, Usman, Anee, Razalli, Nurul H, Sambanthamurthi, Ravigadevi, Gupta, Smiti V

“…Oil palm phenolics (OPP) or Palm Juice (PJ), a water soluble extract from the palm fruit (Elaies guineensis) has been documented to have anti-carcinogenic…”
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Garcinol Inhibits Cell Proliferation and Promotes Apoptosis in Pancreatic Adenocarcinoma Cells by Parasramka, Mansi A, Gupta, Smiti V

“…Garcinol, or polyisoprenylated benzophenone, isolated from the rind of fruiting bodies of Garcinia indica, has been used in traditional medicine for its…”
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Corrigendum to “Cardiolipin-deficient cells depend on anaplerotic pathways to ameliorate defective TCA cycle function” [Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1864/5(2019) 654-661] by Raja, Vaishnavi, Salsaa, Michael, Joshi, Amit S., Li, Yiran, van Roermund, Carlo W.T., Saadat, Nadia, Lazcano, Pablo, Schmidtke, Michael, Hüttemann, Maik, Gupta, Smiti V., Wanders, Ronald J.A., Greenberg, Miriam L.

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Delta-tocotrienol Augments Cisplatin-induced Suppression of Non-small Cell Lung Cancer Cells via Inhibition of the Notch-1 Pathway by XIANGMING JI, ZHIWEI WANG, SARKAR, Fazlul H, GUPTA, Smiti V

“…Non-small cell lung cancer (NSCLC), accounting for 80% of lung cancers, is the leading cause of all cancer deaths. Previously, we demonstrated that…”
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Tocotrienol-rich mixture inhibits cell proliferation and induces apoptosis via down-regulation of the Notch-1/NF-κB pathways in NSCLC cells by Rajasinghe, Lichchavi D, Gupta, Smiti V

“…Lung cancer is one of the leading causes of cancer deaths. Non-small cell lung cancer (NSCLC), with a 5-year survival rate of 5% at stage IIIB, accounts for…”
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ProAlgaZyme subfraction improves the lipoprotein profile of hypercholesterolemic hamsters, while inhibiting production of betaine, carnitine, and choline metabolites by Geamanu, Andreea, Goja, Arvind, Saadat, Nadia, Khosla, Pramod, Gupta, Smiti V

“…BACKGROUND: Previously, we reported that ProAlgaZyme (PAZ) and its biologically active fraction improved plasma lipids in hypercholesterolemic hamsters, by…”
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Differences in metabolomic profiles of male db/db and s/s, leptin receptor mutant mice by Saadat, Nadia, IglayReger, Heidi B, Myers, Jr, Martin G, Bodary, Peter, Gupta, Smiti V

“…Leptin, a protein hormone secreted by adipose tissue, plays an important role in regulating energy metabolism and the immune response. Despite similar extremes…”
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Quantification of 20-hydroxyeicosatetraenoic acid by colorimetric competitive enzyme linked immunosorbent assay by Grates, Harry E, McGowen, Richard M, Gupta, Smiti V, Falck, John R, Brown, Thomas R, Callewaert, Denis M, Sasaki, Diane M

“…Analysis of 20-hydroxyeicosatetraenoic acid (20-HETE), a potent vasoconstrictor produced by the cytochrome P450 pathway, presently requires high-performance…”
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Modulation of the Sin3/HDAC Complex by Dietary Bioactive Agent Delta-Tocotrienol in a Human Lung Cancer Cell Model by Hutchings, Melanie, Gupta, Smiti V

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ProAlgaZyme and its subfractions increase plasma HDL cholesterol via upregulation of ApoA1, ABCA1, and SRB1, and inhibition of CETP in hypercholesterolemic hamsters by Geamanu, Andreea, Saadat, Nadia, Goja, Arvind, Wadehra, Monika, Ji, Xiangming, Gupta, Smiti V

“…Background: Plasma HDL cholesterol levels are inversely related to cardiovascular disease, which is the leading cause of death worldwide. This study…”
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Delta Tocotrienal Inhibit mTOR Pathway by Modulating Glutamine Uptake and Transporters in Non‐Small Cell Lung Cancer by Rajasinghe, Lichchavi Dhananjaya, Gupta, Smiti V.

“…Abstract only Lung cancer, with the majority of cases being non‐small cell lung cancer (NSCLC), is one of the leading causes of death among cancers. NSCLC has…”
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Pork fat and chicken fat similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid by Gupta, S V, Khosla, P

“…The effects on plasma lipoprotein metabolism of replacing pork fat (PF) with chicken fat (CF) (formulated as part of currently recommended prudent diets) was…”
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Effect of an algal infusion (AI) on plasma metabolomic profile in hypercholesterolemic hamsters by Geamanu, Andreea, Saadat, Nadia, Goja, Arvind, Gupta, Smiti V

“…Abstract only Cardiovascular disease (CVD) is the leading cause of death worldwide. Major risk factors for CVD, including elevated LDL and low HDL were…”
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