Search Results - "Gupta, Rohan"

Current and future therapies for advanced pancreatic cancer by Gupta, Rohan, Amanam, Idoroenyi, Chung, Vincent

“…Pancreatic cancer remains a deadly disease with a 5‐year survival rate of only 8%. Even after surgical resection, most patients have recurrence of their…”
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Artificial intelligence to deep learning: machine intelligence approach for drug discovery by Gupta, Rohan, Srivastava, Devesh, Sahu, Mehar, Tiwari, Swati, Ambasta, Rashmi K., Kumar, Pravir

“…Drug designing and development is an important area of research for pharmaceutical companies and chemical scientists. However, low efficacy, off-target…”
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Pharmacological intervention of histone deacetylase enzymes in the neurodegenerative disorders by Gupta, Rohan, Ambasta, Rashmi K., Kumar, Pravir

“…Reversal of aging symptoms and related disorders are the challenging task where epigenetic is a crucial player that includes DNA methylation, histone…”
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In Vivo Assessment of Cell Death and Nigrostriatal Pathway Integrity Following Continuous Expression of C3 Transferase by Gupta, Rohan V., Santiago-Lopez, Angel J., Berglund, Ken, Gross, Robert E., Gutekunst, Claire-Anne N.

“…[Display omitted] •Development of Cre-dependent viral vectors for targeted C3 transferase delivery.•C3 transferase expression does not lead to cell loss in the…”
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Creative destruction: New protein folds from old by Alvarez-Carreño, Claudia, Gupta, Rohan J, Petrov, Anton S, Williams, Loren Dean

“…Mechanisms of emergence and divergence of protein folds pose central questions in biological sciences. Incremental mutation and stepwise adaptation explain…”
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Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions by Jarrahi, Abbas, Braun, Molly, Ahluwalia, Meenakshi, Gupta, Rohan V, Wilson, Michael, Munie, Stephanie, Ahluwalia, Pankaj, Vender, John R, Vale, Fernando L, Dhandapani, Krishnan M, Vaibhav, Kumar

“…Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is crucial for developing new therapies for TBI. Current treatments for TBI…”
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Identification of novel class I and class IIb histone deacetylase inhibitor for Alzheimer's disease therapeutics by Gupta, Rohan, Ambasta, Rashmi K., Kumar, Pravir

“…Histone deacetylase enzymes were prominent chromatin remodeling drug that targets in the pathophysiology of Alzheimer's disease associated with transcriptional…”
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Impact Total Psoas Volume on Short- and Long-Term Outcomes in Patients Undergoing Curative Resection for Pancreatic Adenocarcinoma: a New Tool to Assess Sarcopenia by Amini, Neda, Spolverato, Gaya, Gupta, Rohan, Margonis, Georgios A., Kim, Yuhree, Wagner, Doris, Rezaee, Neda, Weiss, Matthew J., Wolfgang, Christopher L., Makary, Martin M., Kamel, Ihab R., Pawlik, Timothy M.

“…Background While sarcopenia is typically defined using total psoas area (TPA), characterizing sarcopenia using only a single axial cross-sectional image may be…”
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Branched nozzle oblique angle flow for initiated chemical vapor deposition by Welchert, Nicholas A., Swarup, Jay V., Gupta, Rohan S., Gupta, Malancha

“…Monomer precursor flow was introduced at an oblique angle to the substrate at two locations during the initiated chemical vapor deposition (iCVD) process using…”
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CREB1K292 and HINFPK330 as Putative Common Therapeutic Targets in Alzheimer’s and Parkinson’s Disease by Gupta, Rohan, Kumar, Pravir

“…Integration of omics data and deciphering the mechanism of a biological regulatory network could be a promising approach to reveal the molecular mechanism…”
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No Hay Racismo?: application of the levels of racism framework to Latinx perspectives on barriers to health and wellbeing by Plasencia, Gabriela, Kaalund, Kamaria, Gupta, Rohan, Martinez-Bianchi, Viviana, Gonzalez-Guarda, Rosa, Sperling, Jessica, Thoumi, Andrea

“…The purpose of this study is to increase understanding of the forms of systemic racism experienced by Latinx communities in North Carolina during the COVID-19…”
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Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer’s and Parkinson’s Disease by Gupta, Rohan, Kumar, Pravir

“…Aim/Hypothesis : Lysine residues are known for the post-translational modifications (PTMs) such as acetylation, ubiquitination, and SUMOylation. In…”
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Modeling the Subclonal Evolution of Cancer Cell Populations by Chowell, Diego, Napier, James, Gupta, Rohan, Anderson, Karen S, Maley, Carlo C, Sayres, Melissa A Wilson

“…Increasing evidence shows that tumor clonal architectures are often the consequence of a complex branching process, yet little is known about the expected…”
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Uneven terrain treadmill walking in younger and older adults by Downey, Ryan J, Richer, Natalie, Gupta, Rohan, Liu, Chang, Pliner, Erika M, Roy, Arkaprava, Hwang, Jungyun, Clark, David J, Hass, Chris J, Manini, Todd M, Seidler, Rachael D, Ferris, Daniel P

“…We developed a method for altering terrain unevenness on a treadmill to study gait kinematics. Terrain consisted of rigid polyurethane disks (12.7 cm diameter,…”
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Quality of life after treatment of neuroendocrine liver metastasis by Spolverato, Gaya, MD, Bagante, Fabio, MD, Wagner, Doris, MD, Buettner, Stefan, MD, Gupta, Rohan, MD, Kim, Yuhree, MD, Maqsood, Hadia, MD, Pawlik, Timothy M., MD, MPH, PhD

“…Abstract Background A large subset of patients with neuroendocrine liver metastasis (NELM) is symptomatic at the time of presentation. In addition to improving…”
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An Investigation on the Audio-Video Data Based Estimation of Emotion Regulation Difficulties and Their Association With Mental Disorders by Gupta, Rohan kumar, Sinha, Rohit

“…It is reported that emotion regulation difficulties (ERD) happen to characterize several mental disorders. This finding is made based on self-report measures…”
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Secure and Fine-Grained Access Control With Optimized Revocation for Outsourced IoT EHRs With Adaptive Load-Sharing in Fog-Assisted Cloud Environment by Fugkeaw, Somchart, Prasad Gupta, Rohan, Worapaluk, Khanadech

“…With the employment of IoT technology and cloud computing in healthcare, outsourcing Electronic Health Records (EHRs) generated by IoT devices becomes the…”
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Roseomonas mucosa-Induced Peritonitis in a Patient Undergoing Continuous Cycler Peritoneal Dialysis: Case Report and Literature Analysis by Roy, Sasmit, Patel, Sumit, Kummamuru, Hardhik, Garcha, Amarinder Singh, Gupta, Rohan, Adapa, Sreedhar

“…Roseomonas species, a rare Gram-negative microorganism, has seldom been reported to cause peritonitis in end-stage renal disease patients on peritoneal…”
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Value of a UK medical degree for international students (VISION): a cross-sectional study by Li, Chun Hei, Ganesananthan, Sashiananthan, Pinchemain, Trevor, Godoi, Amanda, Lim, Shan Ming, Baskaran, Ravanth, Mukhopadhyay, Srinjay, Foo, Eu Fang, Ooi, Setthasorn Zhi Yang, Woo, Timothy, Yeo, Vanessa, Sweetland, Helen, Pillarisetti, Sai Ram, Gupta, Paarth Kishan, Punia, Renee, Cheung, Katie, Jhaveri, Diva, Gnanabalan, Aaron, Leech, Italia-Rosa, Lee, Faith, Wong, Elizabeth, Phoong, Kar Yen, Moyo, Memory, Thakar, Isha, Shah, Viraj, Gupta, Rohan, Rakhecha, Tushar, Gamage, Movin Peramuna, Dalavye, Nishaanth, Mathew, Allen, Sureshkumarnair, Parvathy, Srinivasan, Sripradha, Leveridge, Becky

“…ObjectivesIt is estimated that NHS staff consist of over 200 different nationalities, with a reported 30.7% of doctors holding a nationality other than…”
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Automated HL7v2 LRI informatics framework for streamlining genomics-EHR data integration by Dolin, Robert H., Gupta, Rohan, Newsom, Kimberly, Heale, Bret S.E., Gothi, Shailesh, Starostik, Petr, Chamala, Srikar

“…While VCF formatted files are the lingua franca of next-generation sequencing, most EHRs do not provide native VCF support. As a result, labs often must send…”
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