Search Results - "Gupta, Rajat"

Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9 by Gupta, Rajat M, Musunuru, Kiran

“…The past decade has been one of rapid innovation in genome-editing technology. The opportunity now exists for investigators to manipulate virtually any gene in…”
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Causal Gene Confusion: The Complicated EDN1/PHACTR1 Locus for Coronary Artery Disease by Gupta, Rajat M.

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Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations by Kalluri, Aditya S, Vellarikkal, Shamsudheen K, Edelman, Elazer R, Nguyen, Lan, Subramanian, Ayshwarya, Ellinor, Patrick T, Regev, Aviv, Kathiresan, Sekar, Gupta, Rajat M

“…BACKGROUND:The cells that form the arterial wall contribute to multiple vascular diseases. The extent of cellular heterogeneity within these populations has…”
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Linking regulation of nitric oxide to endothelin-1: The Yin and Yang of vascular tone in the atherosclerotic plaque by Gupta, Rajat M., Libby, Peter, Barton, Matthias

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The Aging Aorta: Are We Only as Old as Our Endothelium? by Gupta, Rajat M., Plutzky, Jorge

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The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies by Pepin, Mark E, Gupta, Rajat M

“…Endothelial cells (ECs) mediate several biological functions that are relevant to atherosclerosis and coronary artery disease (CAD), regulating an array of…”
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DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity by Gupta, Rajat, Somyajit, Kumar, Narita, Takeo, Maskey, Elina, Stanlie, Andre, Kremer, Magdalena, Typas, Dimitris, Lammers, Michael, Mailand, Niels, Nussenzweig, Andre, Lukas, Jiri, Choudhary, Chunaram

“…Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining…”
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Transesterification of soybean oil at room temperature using biowaste as catalyst; an experimental investigation on the effect of co-solvent on biodiesel yield by Laskar, Ikbal Bahar, Deshmukhya, Tuhin, Bhanja, Piyali, Paul, Bappi, Gupta, Rajat, Chatterjee, Sushovan

“…We report herein, Soybean oil was shaped to biodiesel using CaO as heterogeneous catalyst and acetone as cosolvent by employing transesterification reaction at…”
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Hippo Pathway Looms Large for the Function of the JCAD (Junctional Protein Associated With Coronary Artery Disease) on Endothelial Cells by Gupta, Rajat M

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Prevalence and determinants of hypertension among adult population in Nepal: Data from Nepal Demographic and Health Survey 2016 by Hasan, Mehedi, Sutradhar, Ipsita, Akter, Tahmina, Das Gupta, Rajat, Joshi, Hemraj, Haider, Mohammad Rifat, Sarker, Malabika

“…Like other developing countries, Nepal is currently going through epidemiological transition along with rising burden of Non-communicable Diseases. However,…”
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The March of Monocytes in Atherosclerosis: One Cell at a Time by Gupta, Rajat M., Lee-Kim, Vivian S., Libby, Peter

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Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association by Musunuru, Kiran, Sheikh, Farah, Gupta, Rajat M, Houser, Steven R, Maher, Kevin O, Milan, David J, Terzic, Andre, Wu, Joseph C

“…Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human physiology and disease at the cellular level. They also have the…”
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Prevalence of chronic kidney disease in South Asia: a systematic review by Hasan, Mehedi, Sutradhar, Ipsita, Gupta, Rajat Das, Sarker, Malabika

“…Chronic kidney disease (CKD) is becoming a major public health problem around the world. But the prevalence has not been reported in South Asian region as a…”
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A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models by Ding, Qiurong, Lee, Youn-Kyoung, Schaefer, Esperance A.K., Peters, Derek T., Veres, Adrian, Kim, Kevin, Kuperwasser, Nicolas, Motola, Daniel L., Meissner, Torsten B., Hendriks, William T., Trevisan, Marta, Gupta, Rajat M., Moisan, Annie, Banks, Eric, Friesen, Max, Schinzel, Robert T., Xia, Fang, Tang, Alexander, Xia, Yulei, Figueroa, Emmanuel, Wann, Amy, Ahfeldt, Tim, Daheron, Laurence, Zhang, Feng, Rubin, Lee L., Peng, Lee F., Chung, Raymond T., Musunuru, Kiran, Cowan, Chad A.

“…Transcription activator-like effector nucleases (TALENs) are a new class of engineered nucleases that are easier to design to cleave at desired sites in a…”
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Prevalence and associated factors of underweight, overweight and obesity among women of reproductive age group in the Maldives: Evidence from a nationally representative study by Hashan, Mohammad Rashidul, Rabbi, Md Fazla, Haider, Shams Shabab, Das Gupta, Rajat

“…Global epidemiological transition across various countries have documented the coexistence of undernutrition and overnutrition. South Asian countries are…”
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The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy by Garg, Manoj, Shanmugam, Muthu K., Bhardwaj, Vipul, Goel, Akul, Gupta, Rajat, Sharma, Arundhiti, Baligar, Prakash, Kumar, Alan Prem, Goh, Boon Cher, Wang, Lingzhi, Sethi, Gautam

“…Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription factors, responsible for regulating cellular proliferation,…”
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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases by Weeks, Elle M., Ulirsch, Jacob C., Cheng, Nathan Y., Trippe, Brian L., Fine, Rebecca S., Miao, Jenkai, Patwardhan, Tejal A., Kanai, Masahiro, Nasser, Joseph, Fulco, Charles P., Tashman, Katherine C., Aguet, Francois, Li, Taibo, Ordovas-Montanes, Jose, Smillie, Christopher S., Biton, Moshe, Shalek, Alex K., Ananthakrishnan, Ashwin N., Xavier, Ramnik J., Regev, Aviv, Gupta, Rajat M., Lage, Kasper, Ardlie, Kristin G., Hirschhorn, Joel N., Lander, Eric S., Engreitz, Jesse M., Finucane, Hilary K.

“…Genome-wide association studies (GWASs) are a valuable tool for understanding the biology of complex human traits and diseases, but associated variants rarely…”
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A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression by Gupta, Rajat M., Hadaya, Joseph, Trehan, Aditi, Zekavat, Seyedeh M., Roselli, Carolina, Klarin, Derek, Emdin, Connor A., Hilvering, Catharina R.E., Bianchi, Valerio, Mueller, Christian, Khera, Amit V., Ryan, Russell J.H., Engreitz, Jesse M., Issner, Robbyn, Shoresh, Noam, Epstein, Charles B., de Laat, Wouter, Brown, Jonathan D., Schnabel, Renate B., Bernstein, Bradley E., Kathiresan, Sekar

“…Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine…”
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HiDDEN: a machine learning method for detection of disease-relevant populations in case-control single-cell transcriptomics data by Goeva, Aleksandrina, Dolan, Michael-John, Luu, Judy, Garcia, Eric, Boiarsky, Rebecca, Gupta, Rajat M., Macosko, Evan

“…In case-control single-cell RNA-seq studies, sample-level labels are transferred onto individual cells, labeling all case cells as affected, when in reality…”
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Assessing the Magnitude and Likely Causes of Summertime Overheating in Modern Flats in UK by Gupta, Rajat, Gregg, Matt

“…There has been increasing recognition that climate change may lead to risk of summertime overheating in UK dwellings with potentially adverse consequences for…”
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