Search Results - "Gupta, Nalin"

The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes by Farmer, Diana L., Thom, Elizabeth A., Brock, John W., Burrows, Pamela K., Johnson, Mark P., Howell, Lori J., Farrell, Jody A., Gupta, Nalin, Adzick, N. Scott

“…Previous reports from the Management of Myelomeningocele Study demonstrated that prenatal repair of myelomeningocele reduces hindbrain herniation and the need…”
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A single-cell atlas of the normal and malformed human brain vasculature by Winkler, Ethan A, Kim, Chang N, Ross, Jayden M, Garcia, Joseph H, Gil, Eugene, Oh, Irene, Chen, Lindsay Q, Wu, David, Catapano, Joshua S, Raygor, Kunal, Narsinh, Kazim, Kim, Helen, Weinsheimer, Shantel, Cooke, Daniel L, Walcott, Brian P, Lawton, Michael T, Gupta, Nalin, Zlokovic, Berislav V, Chang, Edward F, Abla, Adib A, Lim, Daniel A, Nowakowski, Tomasz J

“…Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies…”
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Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups by Pajtler, Kristian W., Witt, Hendrik, Sill, Martin, Jones, David T.W., Hovestadt, Volker, Kratochwil, Fabian, Wani, Khalida, Tatevossian, Ruth, Punchihewa, Chandanamali, Johann, Pascal, Reimand, Jüri, Warnatz, Hans-Jörg, Ryzhova, Marina, Mack, Steve, Ramaswamy, Vijay, Capper, David, Schweizer, Leonille, Sieber, Laura, Wittmann, Andrea, Huang, Zhiqin, van Sluis, Peter, Volckmann, Richard, Koster, Jan, Versteeg, Rogier, Fults, Daniel, Toledano, Helen, Avigad, Smadar, Hoffman, Lindsey M., Donson, Andrew M., Foreman, Nicholas, Hewer, Ekkehard, Zitterbart, Karel, Gilbert, Mark, Armstrong, Terri S., Gupta, Nalin, Allen, Jeffrey C., Karajannis, Matthias A., Zagzag, David, Hasselblatt, Martin, Kulozik, Andreas E., Witt, Olaf, Collins, V. Peter, von Hoff, Katja, Rutkowski, Stefan, Pietsch, Torsten, Bader, Gary, Yaspo, Marie-Laure, von Deimling, Andreas, Lichter, Peter, Taylor, Michael D., Gilbertson, Richard, Ellison, David W., Aldape, Kenneth, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan M.

“…Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification…”
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Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma by Hashizume, Rintaro, Andor, Noemi, Ihara, Yuichiro, Lerner, Robin, Gan, Haiyun, Chen, Xiaoyue, Fang, Dong, Huang, Xi, Tom, Maxwell W, Ngo, Vy, Solomon, David, Mueller, Sabine, Paris, Pamela L, Zhang, Zhiguo, Petritsch, Claudia, Gupta, Nalin, Waldman, Todd A, James, C David

“…Hashizume et al . report a new therapeutic strategy for treating pediatric gliomas with mutations in the H3F3A gene by inhibiting histone demethylation…”
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CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury by Morganti, Josh M, Jopson, Timothy D, Liu, Sharon, Riparip, Lara-Kirstie, Guandique, Cristian K, Gupta, Nalin, Ferguson, Adam R, Rosi, Susanna

“…Traumatic brain injury (TBI) is a major risk factor for the development of multiple neurodegenerative diseases. With respect to the increasing prevalence of…”
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The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression by Chan, Kui-Ming, Fang, Dong, Gan, Haiyun, Hashizume, Rintaro, Yu, Chuanhe, Schroeder, Mark, Gupta, Nalin, Mueller, Sabine, James, C David, Jenkins, Robert, Sarkaria, Jann, Zhang, Zhiguo

“…Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of…”
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Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons by Pearson, Toni S., Gupta, Nalin, San Sebastian, Waldy, Imamura-Ching, Jill, Viehoever, Amy, Grijalvo-Perez, Ana, Fay, Alex J., Seth, Neha, Lundy, Shannon M., Seo, Youngho, Pampaloni, Miguel, Hyland, Keith, Smith, Erin, de Oliveira Barbosa, Gardenia, Heathcock, Jill C., Minnema, Amy, Lonser, Russell, Elder, J. Bradley, Leonard, Jeffrey, Larson, Paul, Bankiewicz, Krystof S.

“…Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in…”
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Prenatal Repair of Myelomeningocele and School-age Functional Outcomes by Houtrow, Amy J, Thom, Elizabeth A, Fletcher, Jack M, Burrows, Pamela K, Adzick, N Scott, Thomas, Nina H, Brock, 3rd, John W, Cooper, Timothy, Lee, Hanmin, Bilaniuk, Larissa, Glenn, Orit A, Pruthi, Sumit, MacPherson, Cora, Farmer, Diana L, Johnson, Mark P, Howell, Lori J, Gupta, Nalin, Walker, William O

“…The Management of Myelomeningocele Study (MOMS), a randomized trial of prenatal versus postnatal repair for myelomeningocele, found that prenatal surgery…”
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Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy by Panditharatna, Eshini, Kilburn, Lindsay B, Aboian, Mariam S, Kambhampati, Madhuri, Gordish-Dressman, Heather, Magge, Suresh N, Gupta, Nalin, Myseros, John S, Hwang, Eugene I, Kline, Cassie, Crawford, John R, Warren, Katherine E, Cha, Soonmee, Liang, Winnie S, Berens, Michael E, Packer, Roger J, Resnick, Adam C, Prados, Michael, Mueller, Sabine, Nazarian, Javad

“…Pediatric diffuse midline glioma (DMG) are highly malignant tumors with poor clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M…”
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A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele by Adzick, N. Scott, Thom, Elizabeth A, Spong, Catherine Y, Brock, John W, Burrows, Pamela K, Johnson, Mark P, Howell, Lori J, Farrell, Jody A, Dabrowiak, Mary E, Sutton, Leslie N, Gupta, Nalin, Tulipan, Noel B, D'Alton, Mary E, Farmer, Diana L

“…In this trial comparing prenatal repair of myelomeningocele with standard postnatal repair, the prenatal-surgery group had better outcomes and better mental…”
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Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma by Fontebasso, Adam M, Papillon-Cavanagh, Simon, Schwartzentruber, Jeremy, Nikbakht, Hamid, Gerges, Noha, Fiset, Pierre-Olivier, Bechet, Denise, Faury, Damien, De Jay, Nicolas, Ramkissoon, Lori A, Corcoran, Aoife, Jones, David T W, Sturm, Dominik, Johann, Pascal, Tomita, Tadanori, Goldman, Stewart, Nagib, Mahmoud, Bendel, Anne, Goumnerova, Liliana, Bowers, Daniel C, Leonard, Jeffrey R, Rubin, Joshua B, Alden, Tord, Browd, Samuel, Geyer, J Russell, Leary, Sarah, Jallo, George, Cohen, Kenneth, Gupta, Nalin, Prados, Michael D, Carret, Anne-Sophie, Ellezam, Benjamin, Crevier, Louis, Klekner, Almos, Bognar, Laszlo, Hauser, Peter, Garami, Miklos, Myseros, John, Dong, Zhifeng, Siegel, Peter M, Malkin, Hayley, Ligon, Azra H, Albrecht, Steffen, Pfister, Stefan M, Ligon, Keith L, Majewski, Jacek, Jabado, Nada, Kieran, Mark W

“…Nada Jabado and colleagues report identification of gain-of-function mutations in ACVR1 , which encodes activin A receptor type I, in midline pediatric…”
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Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis by Thompson, Eric M, MD, Hielscher, Thomas, MSc, Bouffet, Eric, Prof, Remke, Marc, MD, Luu, Betty, BSc, Gururangan, Sridharan, Prof, McLendon, Roger E, Prof, Bigner, Darell D, Prof, Lipp, Eric S, MD, Perreault, Sebastien, MD, Cho, Yoon-Jae, MD, Grant, Gerald, MD, Kim, Seung-Ki, Prof, Lee, Ji Yeoun, MD, Rao, Amulya A Nageswara, MD, Li, Kay Ka Wai, MD, Ng, Ho-Keung, Prof, Yao, Yu, MD, Kumabe, Toshihiro, MD, Tominaga, Teiji, Prof, Grajkowska, Wieslawa A, Prof, Perek-Polnik, Marta, Prof, Low, David C Y, MBBCh, Seow, Wan Tew, MBBS, Chang, Kenneth T E, MBBCh, Mora, Jaume, Prof, Pollack, Ian F, Prof, Hamilton, Ronald L, MD, Leary, Sarah, MD, Moore, Andrew S, PhD, Ingram, Wendy J, PhD, Hallahan, Andrew R, MBBS, Jouvet, Anne, MD, Fèvre-Montange, Michelle, PhD, Vasiljevic, Alexandre, MD, Faure-Conter, Cecile, MD, Shofuda, Tomoko, PhD, Hashimoto, Naoya, MD, Jabado, Nada, MD, Weil, Alexander G, MD, Gayden, Tenzin, PhD, Wataya, Takafumi, MD, Shalaby, Tarek, MD, Grotzer, Michael, Prof, Zitterbart, Karel, PhD, Sterba, Jaroslav, Prof, Kren, Leos, MD, Hortobágyi, Tibor, Prof, Klekner, Almos, PhD, László, Bognár, Prof, Pócza, Tímea, MSc, Hauser, Peter, MD, Schüller, Ulrich, MD, Jung, Shin, Prof, Jang, Woo-Youl, MD, French, Pim J, Prof, Kros, Johan M, Prof, van Veelen, Marie-Lise C, MD, Massimi, Luca, MD, Leonard, Jeffrey R, Prof, Rubin, Joshua B, MD, Vibhakar, Rajeev, MD, Chambless, Lola B, MD, Cooper, Michael K, MD, Thompson, Reid C, Prof, Carvalho, Alice, MD, Nunes, Sofia, MD, Pimentel, José, MD, Fan, Xing, MD, Lyden, David, Prof, Garzia, Livia, PhD, Shih, David J H, PhD, Kijima, Noriyuki, MD, Schneider, Christian, MD, Adamski, Jennifer, PhD, Northcott, Paul A, PhD, Kool, Marcel, PhD, Jones, David T W, PhD, Chan, Jennifer A, MD, Nikolic, Ana, MD, Garre, Maria Luisa, MD, Van Meir, Erwin G, Prof, Osuka, Satoru, MD, Olson, Jeffrey J, Prof, Jahangiri, Arman, BSc, Castro, Brandyn A, BSc, Gupta, Nalin, MD, Moxon-Emre, Iska, MSc, Mabbott, Donald J, PhD, Lassaletta, Alvaro, MD, Hawkins, Cynthia E, Prof, Tabori, Uri, MD, Drake, James, Prof, Kulkarni, Abhaya, Prof, Dirks, Peter, Prof, Rutka, James T, Prof, Pfister, Stefan M, Prof, Packer, Roger J, Prof, Ramaswamy, Vijay, MD, Taylor, Michael D, Dr Prof

“…Summary Background Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which…”
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CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma by Liu, S John, Malatesta, Martina, Lien, Brian V, Saha, Parna, Thombare, Shivani S, Hong, Sung Jun, Pedraza, Leslie, Koontz, Mark, Seo, Kyounghee, Horlbeck, Max A, He, Daniel, Birk, Harjus S, Jain, Miten, Olsen, Hugh E, Akeson, Mark, Weissman, Jonathan S, Monje, Michelle, Gupta, Nalin, Raleigh, David R, Ullian, Erik M, Lim, Daniel A

“…Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer…”
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Pediatric high-grade glioma: biologically and clinically in need of new thinking by Jones, Chris, Karajannis, Matthias A, Jones, David T W, Kieran, Mark W, Monje, Michelle, Baker, Suzanne J, Becher, Oren J, Cho, Yoon-Jae, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A, Jabado, Nada, Li, Xiao-Nan, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J, Persson, Anders I, Phillips, Joanna J, Simonds, Erin F, Stafford, James M, Tang, Yujie, Pfister, Stefan M, Weiss, William A

“…High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed…”
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Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma by ZHUKOVA, Nataliya, RAMASWAMY, Vijay, VON BUEREN, André O, JONES, David T. W, NORTHCOTT, Paul A, KOOL, Marcel, STURM, Dominik, PUGH, Trevor J, POMEROY, Scott L, CHO, Yoon-Jae, PIETSCH, Torsten, GESSI, Marco, REMKE, Marc, RUTKOWSKI, Stefan, BOGNAR, Laszlo, KLEKNER, Almos, CHO, Byung-Kyu, KIM, Seung-Ki, WANG, Kyu-Chang, EBERHART, Charles G, FEVRE-MONTANGE, Michelle, FOULADI, Maryam, FRENCH, Pim J, PFAFF, Elke, KROS, Max, GRAJKOWSKA, Wieslawa A, GUPTA, Nalin, WEISS, William A, HAUSER, Peter, JABADO, Nada, JOUVET, Anne, SHIN JUNG, KUMABE, Toshihiro, LACH, Boleslaw, SHIH, David J. H, LEONARD, Jeffrey R, RUBIN, Joshua B, LIAU, Linda M, MASSIMI, Luca, POLLACK, Ian F, YOUNG SHIN RA, VAN MEIR, Erwin G, ZITTERBART, Karel, SCHÜLLER, Ulrich, HILL, Rebecca M, MARTIN, Dianna C, LINDSEY, Janet C, SCHWALBE, Ed C, BAILEY, Simon, ELLISON, David W, HAWKINS, Cynthia, MALKIN, David, CLIFFORD, Steven C, KORSHUNOV, Andrey, PFISTER, Stefan, TAYLOR, Michael D, CASTELO-BRANCO, Pedro, BASKIN, Berivan, RAY, Peter N, BOUFFET, Eric

“…Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of…”
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Interdisciplinary care of children with diffuse midline glioma by Coleman, Christina, Chen, Katherine, Lu, Alex, Seashore, Elizabeth, Stoller, Schuyler, Davis, Taron, Braunstein, Steve, Gupta, Nalin, Mueller, Sabine

“…•Diffuse midline glioma is a terminal disease that requires interdisciplinary care.•Biopsy should be offered to patients with diffuse midline glioma.•Clinical…”
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The genetic landscape of anaplastic pleomorphic xanthoastrocytoma by Phillips, Joanna J., Gong, Henry, Chen, Katharine, Joseph, Nancy M., van Ziffle, Jessica, Bastian, Boris C., Grenert, James P., Kline, Cassie N., Mueller, Sabine, Banerjee, Anuradha, Nicolaides, Theodore, Gupta, Nalin, Berger, Mitchel S., Lee, Han S., Pekmezci, Melike, Tihan, Tarik, Bollen, Andrew W., Perry, Arie, Shieh, Joseph T.C., Solomon, David A.

“…Pleomorphic xanthoastrocytoma (PXA) is an astrocytic neoplasm that is typically well circumscribed and can have a relatively favorable prognosis. Tumor…”
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Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration by Morganti, Josh M, Jopson, Timothy D, Liu, Sharon, Gupta, Nalin, Rosi, Susanna

“…Therapeutic irradiation is commonly used to treat primary or metastatic central nervous system tumors. It is believed that activation of neuroinflammatory…”
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Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model by Feng, Xi, Liu, Sharon, Chen, David, Rosi, Susanna, Gupta, Nalin

“…More than half of long-term brain tumor survivors develop irreversible cognitive decline that severely affect their quality of life. However, there is no…”
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Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma by Witt, Hendrik, Mack, Stephen C., Ryzhova, Marina, Bender, Sebastian, Sill, Martin, Isserlin, Ruth, Benner, Axel, Hielscher, Thomas, Milde, Till, Remke, Marc, Jones, David T.W., Northcott, Paul A., Garzia, Livia, Bertrand, Kelsey C., Wittmann, Andrea, Yao, Yuan, Roberts, Stephen S., Massimi, Luca, Van Meter, Tim, Weiss, William A., Gupta, Nalin, Grajkowska, Wiesia, Lach, Boleslaw, Cho, Yoon-Jae, von Deimling, Andreas, Kulozik, Andreas E., Witt, Olaf, Bader, Gary D., Hawkins, Cynthia E., Tabori, Uri, Guha, Abhijit, Rutka, James T., Lichter, Peter, Korshunov, Andrey, Taylor, Michael D., Pfister, Stefan M.

“…Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a…”
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