Search Results - "Gupta, Mukesh"

Enhanced stem cell retention and antioxidative protection with injectable, ROS-degradable PEG hydrogels by Martin, John R., Patil, Prarthana, Yu, Fang, Gupta, Mukesh K., Duvall, Craig L.

“…Poly(ethylene glycol) (PEG) hydrogels crosslinked with enzyme-cleavable peptides are promising biodegradable vehicles for therapeutic cell delivery. However,…”
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Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo by Nelson, Christopher E, Kintzing, James R, Hanna, Ann, Shannon, Joshua M, Gupta, Mukesh K, Duvall, Craig L

“…A family of pH-responsive diblock polymers composed of poly[(ethylene glycol)-b-[(2-(dimethylamino)ethyl methacrylate)-co-(butyl methacrylate)],…”
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Cell Protective, ABC Triblock Polymer-Based Thermoresponsive Hydrogels with ROS-Triggered Degradation and Drug Release by Gupta, Mukesh K, Martin, John R, Werfel, Thomas A, Shen, Tianwei, Page, Jonathan M, Duvall, Craig L

“…A combination of anionic and RAFT polymerization was used to synthesize an ABC triblock polymer…”
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Hybrid Shear‐Thinning Hydrogel Integrating Hyaluronic Acid with ROS‐Responsive Nanoparticles by Bezold, Mariah G., Hanna, Andrew R., Dollinger, Bryan R., Patil, Prarthana, Yu, Fang, Duvall, Craig L., Gupta, Mukesh K.

“…Nanoparticle (NP) supra‐assembly offers unique opportunities to tune macroscopic hydrogels’ mechanical strength, material degradation, and drug delivery…”
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Tissue engineering approaches for the in vitro production of spermatids to treat male infertility: A review by Bhaskar, Rakesh, Kumar Gupta, Mukesh, Soon Han, Sung

“…[Display omitted] Infertility influences 8–12% of couples globally with male infertility counting for approximately 50% of all infertility cases. Numerous…”
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Current Progress in Reactive Oxygen Species (ROS)-Responsive Materials for Biomedical Applications by Lee, Sue Hyun, Gupta, Mukesh K., Bang, Jae Beum, Bae, Hojae, Sung, Hak-Joon

“…Recently, significant progress has been made in developing “stimuli‐sensitive” biomaterials as a new therapeutic approach to interact with dynamic…”
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A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species by Martin, John R, Gupta, Mukesh K, Page, Jonathan M, Yu, Fang, Davidson, Jeffrey M, Guelcher, Scott A, Duvall, Craig L

“…Abstract Biodegradable tissue engineering scaffolds are commonly fabricated from poly(lactide-co-glycolide) (PLGA) or similar polyesters that degrade by…”
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Poly(PS-b-DMA) micelles for reactive oxygen species triggered drug release by Gupta, Mukesh K., Meyer, Travis A., Nelson, Christopher E., Duvall, Craig L.

“…A new micelle drug carrier that consists of a diblock polymer of propylene sulfide (PS) and N,N-dimethylacrylamide (poly(PS74-b-DMA310)) has been synthesized…”
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Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers by Miteva, Martina, Kirkbride, Kellye C, Kilchrist, Kameron V, Werfel, Thomas A, Li, Hongmei, Nelson, Christopher E, Gupta, Mukesh K, Giorgio, Todd D, Duvall, Craig L

“…Abstract A series of endosomolytic mixed micelles was synthesized from two diblock polymers, poly[ethylene glycol-b-(dimethylaminoethyl…”
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Effect of vitrification and beta-mercaptoethanol on reactive oxygen species activity and in vitro development of oocytes vitrified before or after in vitro fertilization by Gupta, Mukesh Kumar, Ph.D, Uhm, Sang Jun, Ph.D, Lee, Hoon Taek, Ph.D

“…Objective To investigate the effect of vitrification and beta-mercaptoethanol (β-ME) on reactive oxygen species (ROS) activity and in vitro development of…”
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Reactive oxygen species-degradable polythioketal urethane foam dressings to promote porcine skin wound repair by Patil, Prarthana, Russo, Katherine A, McCune, Joshua T, Pollins, Alonda C, Cottam, Matthew A, Dollinger, Bryan R, DeJulius, Carlisle R, Gupta, Mukesh K, D'Arcy, Richard, Colazo, Juan M, Yu, Fang, Bezold, Mariah G, Martin, John R, Cardwell, Nancy L, Davidson, Jeffrey M, Thompson, Callie M, Barbul, Adrian, Hasty, Alyssa H, Guelcher, Scott A, Duvall, Craig L

“…Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds…”
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Thermogelling, ABC Triblock Copolymer Platform for Resorbable Hydrogels with Tunable, Degradation‐Mediated Drug Release by Gupta, Mukesh K., Martin, John R., Dollinger, Bryan R., Hattaway, Madison E., Duvall, Craig L.

“…Clinical application of injectable, thermoresponsive hydrogels is hindered by lack of degradability and controlled drug release. To overcome these challenges,…”
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Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction by Vanderburgh, Joseph, Hill, Jordan L, Gupta, Mukesh K, Kwakwa, Kristin A, Wang, Sean K, Moyer, Kathleen, Bedingfield, Sean K, Merkel, Alyssa R, d’Arcy, Richard, Guelcher, Scott A, Rhoades, Julie A, Duvall, Craig L

“…Breast cancer patients are at high risk for bone metastasis. Metastatic bone disease is a major clinical problem that leads to a reduction in mobility,…”
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Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis by Bedingfield, Sean K, Colazo, Juan M, Di Francesco, Martina, Yu, Fang, Liu, Danielle D, Di Francesco, Valentina, Himmel, Lauren E, Gupta, Mukesh K, Cho, Hongsik, Hasty, Karen A, Decuzzi, Paolo, Duvall, Craig L

“…Post-traumatic osteoarthritis (PTOA) associated with joint injury triggers a degenerative cycle of matrix destruction and inflammatory signaling, leading to…”
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Nanoparticle‐mediated transgene expression of insulin‐like growth factor 1 in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations by Wilson, Rebecca L., Lampe, Kristin, Gupta, Mukesh K., Duvall, Craig L., Jones, Helen N.

“…Fetal growth restriction (FGR) significantly contributes to neonatal and perinatal morbidity and mortality. Currently, there are no effective treatment options…”
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ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease by Poole, Kristin M, Nelson, Christopher E, Joshi, Rucha V, Martin, John R, Gupta, Mukesh K, Haws, Skylar C, Kavanaugh, Taylor E, Skala, Melissa C, Duvall, Craig L

“…Abstract A new microparticle-based delivery system was synthesized from reactive oxygen species (ROS)-responsive poly(propylene sulfide) (PPS) and tested for…”
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Diflunisal‐loaded poly(propylene sulfide) nanoparticles decrease S. aureus‐mediated bone destruction during osteomyelitis by Ford, Caleb A., Spoonmore, Thomas J., Gupta, Mukesh K., Duvall, Craig L., Guelcher, Scott A., Cassat, James E.

“…Osteomyelitis is a debilitating infection of bone that results in substantial morbidity. Staphylococcus aureus is the most commonly isolated pathogen causing…”
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Shear-thinning hydrogel for allograft cell transplantation and externally controlled transgene expression by Bezold, Mariah G., Dollinger, Bryan R., DeJulius, Carlisle R., Keech, Megan C., Hanna, Andrew R., Kittel, Anna R., Yu, Fang, Gupta, Mukesh K., D'Arcy, Richard, Brunger, Jonathan M., Duvall, Craig L.

“…This work establishes the design of a fully synthetic, shear-thinning hydrogel platform that is injectable and can isolate engineered, allogeneic cell…”
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Reactive Oxygen Species Shielding Hydrogel for the Delivery of Adherent and Nonadherent Therapeutic Cell Types by Dollinger, Bryan R, Gupta, Mukesh K, Martin, John R, Duvall, Craig L

“…Cell therapies suffer from poor survival post-transplant due to placement into hostile implant sites characterized by host immune response and innate…”
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Correlation of the changing trends of red cell distribution width and serum lactate as a prognostic factor in sepsis and septic shock by Gupta, Mukesh, Yadav, Ghanshyam, Singh, Yashpal, Bhalekar, Arvind

“…Background and Aims: Various biomarkers are used for predicting outcome from sepsis and septic shock but single value doesn't give clear-cut picture. Changing…”
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