Search Results - "Gupta, G D"

Structural aspects of triazole derivatives as HSP90 inhibitors for the treatment of cancer: in silico studies by Dhiman, Shubham, Saha, Moumita, Ali, Amena, Ali, Abuzer, Gupta, G. D, Asati, Vivek

“…HSP90, one important class of chaperons has been intensively investigated as a promising and novel class of drug target for cancer therapy from the past few…”
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Recent Updates on Indole Derivatives as Kinase Inhibitors in the Treatment of Cancer by Asati, Vivek, Bhupal, Ritu, Bhattacharya, Sushanta, Kaur, Kamalpreet, Gupta, G D, Pathak, Abhishek, Mahapatra, Debarshi Kar

“…Cancer is becoming a global threat as its treatment accounts for many challenges. Hence, newer inventions prioritize the requirement of developing novel…”
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Meloxicam carbopol-based gels: characterization and evaluation by Sareen, Rashmi, Kumar, Sandeep, Gupta, G D

“…To formulate and evaluate the hydrogels containing meloxicam for topical application and also compare the effect of penetration enhancers on release of drug…”
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Metals associated neurodegeneration in Parkinson’s disease: Insight to physiological, pathological mechanisms and management by Raj, Khadga, Kaur, Pawandeep, Gupta, G.D., Singh, Shamsher

“…•Parkinson’s disease is a multifactorial neurodegenerative disorder caused by various pathological insult led to dopaminergic neurons loss.•Excessive exposure…”
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Pyrazolopyrimidines as anticancer agents: A review on structural and target-based approaches by Asati, Vivek, Anant, Arjun, Patel, Preeti, Kaur, Kamalpreet, Gupta, G.D.

“…Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This scaffold produced numerous biological activities in which anticancer…”
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Adenosine receptor antagonists: Recent advances and therapeutic perspective by Saini, Anjali, Patel, Rajiv, Gaba, Sobhi, Singh, Gurpreet, Gupta, G.D., Monga, Vikramdeep

“…Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues. It regulates various body functions by activating four G-protein…”
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l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease by Raj, Khadga, Gupta, G. D., Singh, Shamsher

“…Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disease, characterized by loss of dopaminergic neurons in substantia nigra,…”
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Formulation and evaluation of extended release asymmetric membrane capsules of atenolol by Guarve, Kumar, Gupta, G D

“…The objective of this study was to demonstrate that the asymmetric membrane capsule can be used to deliver a poorly water soluble drug with a pH dependent…”
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Spermine protects aluminium chloride and iron-induced neurotoxicity in rat model of Alzheimer's disease via attenuation of tau phosphorylation, Amyloid-β (1–42) and NF-κB pathway by Raj, Khadga, Gupta, G. D., Singh, Shamsher

“…Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by a gradual decline in cognitive and memory functions of the aged peoples…”
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Cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and Aβ (1-42) pathway in the hippocampus: An in vivo approach by Aran, Khadga Raj, Gupta, G D, Singh, Shamsher

“…Cladribine is a purine nucleoside found to enhance toxic amyloid protein and cause memory impairment. Patients following chemotherapy treatment commonly suffer…”
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Design, synthesis and antidiabetic study of triazole clubbed indole derivatives as α-glucosidase inhibitors by Ritu, Sharma, Priyanka, Gupta, G.D., Asati, Vivek

“…[Display omitted] •α-Glucosidase is a crucial enzyme in the hydrolysis of carbohydrates.•Design, synthesis, and antidiabetic activity of novel triazole based…”
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A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer by Dubey, Rahul, Sharma, Anushka, Gupta, Shankar, Gupta, G.D., Asati, Vivek

“…[Display omitted] •The present manuscript focuses on various undergoing clinical trials of PI3K inhibitors for breast cancer treatment.•Structure activity…”
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An Investigative Review for Pharmaceutical Analysis of Fenofibrate by Saha, Moumita, Dhiman, Shubham, Gupta, G D, Asati, Vivek

“…Abstract HMG-CoA reductase inhibitors (statins), lipoprotein lipase activators (PPARα agonists) or fibrates are commonly used for controlling increased lipid…”
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Investigation of the anti-cancer potential of epoxyazadiradione in neuroblastoma: experimental assays and molecular analysis by Chandel, Shivani, Bhattacharya, Arka, Gautam, Anupam, Zeng, Wenhuan, Alka, Oliver, Sachsenberg, Timo, Gupta, G. D., Narang, Raj Kumar, Ravichandiran, V., Singh, Rajveer

“…Neuroblastoma, the most common childhood solid tumor, originates from primitive sympathetic nervous system cells. Epoxyazadiradione (EAD) is a limonoid derived…”
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Current understanding on molecular drug targets and emerging treatment strategy for novel coronavirus-19 by Raj, Khadga, Kaur, Karamjeet, Gupta, G. D., Singh, Shamsher

“…SARS-CoV-2 is an enveloped positive-sense RNA virus, contain crown-like spikes on its surface, exceptional of large RNA genome, and a special replication…”
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Identification of potential N-substituted 5-benzylidenethiazolidine-2,4‑dione derivatives as α-amylase inhibitors: Computational cum synthetic studies by Gupta, Shankar, Baweja, Gurkaran Singh, Gupta, GD, Asati, Vivek

“…•3D-QSAR model ford α-amylase inhibitors were developed.•Atom-based, Field-based 3D-QSAR and pharmacophore study were applied with high intercorrelation for…”
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An insight into the medicinal perspective of synthetic analogs of imidazole by Rulhania, Sandeep, Kumar, Shubham, Nehra, Bhupender, Gupta, GD, Monga, Vikramdeep

“…•Imidazole is considered as a privileged scaffold in drug discovery with diverse array of biological properties.•Recent advances in the medicinal chemistry of…”
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Localized topical drug delivery systems for skin cancer: Current approaches and future prospects by Gupta, Nimish, Gupta, G. D., Singh, Dilpreet

“…Topical drug delivery presents a novel substitute to the conventional drug-distribution routes of oral delivery and injection. Apart from the simplicity and…”
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Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats by Aran, Khadga Raj, Gupta, G. D., Singh, Shamsher

“…Objective: To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats. Methods: Rats were administered…”
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A Critical Sojourn of Polymeric Micelles: Technological Concepts, Recent Advances, and Future Prospects by Verma, Princi, Gupta, G D, Markandeywar, Tanmay S, Singh, Dilpreet

“…in vivo…”
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