Search Results - "Gupta, Anoopum S"

At-home wearables and machine learning sensitively capture disease progression in amyotrophic lateral sclerosis by Gupta, Anoopum S., Patel, Siddharth, Premasiri, Alan, Vieira, Fernando

“…Amyotrophic lateral sclerosis causes degeneration of motor neurons, resulting in progressive muscle weakness and impairment in motor function. Promising drug…”
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Assessing Cerebellar Disorders with Wearable Inertial Sensor Data Using Time-Frequency and Autoregressive Hidden Markov Model Approaches by Knudson, Karin C, Gupta, Anoopum S

“…Wearable sensor data is relatively easily collected and provides direct measurements of movement that can be used to develop useful behavioral biomarkers…”
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Segmentation of spatial experience by hippocampal theta sequences by Gupta, Anoopum S, van der Meer, Matthijs A A, Touretzky, David S, Redish, A David

“…This paper reports that hippocampal theta sequences and their corresponding spatial paths stretch forward or backward as a function of an animal's behavior and…”
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Multiscale Fluctuation-Based Dispersion Entropy and Its Applications to Neurological Diseases by Azami, Hamed, Arnold, Steven E., Sanei, Saeid, Chang, Zhuoqing, Sapiro, Guillermo, Escudero, Javier, Gupta, Anoopum S.

“…Fluctuation-based dispersion entropy (FDispEn) is a new approach to estimate the dynamical variability of the fluctuations of signals. It is based on Shannon…”
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Objective Assessment of Upper-Extremity Motor Functions in Spinocerebellar Ataxia Using Wearable Sensors by Mohammadi-Ghazi, Reza, Nguyen, Hung, Mishra, Ram Kinker, Enriquez, Ana, Najafi, Bijan, Stephen, Christopher D, Gupta, Anoopum S, Schmahmann, Jeremy D, Vaziri, Ashkan

“…The study presents a novel approach to objectively assessing the upper-extremity motor symptoms in spinocerebellar ataxia (SCA) using data collected via a…”
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Automatic Classification and Severity Estimation of Ataxia From Finger Tapping Videos by Nunes, Adonay S, Kozhemiako, Nataliia, Stephen, Christopher D, Schmahmann, Jeremy D, Khan, Sheraz, Gupta, Anoopum S

“…Digital assessments enable objective measurements of ataxia severity and provide informative features that expand upon the information obtained during a…”
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Detection of Oculomotor Dysmetria From Mobile Phone Video of the Horizontal Saccades Task Using Signal Processing and Machine Learning Approaches by Azami, Hamed, Chang, Zhuoqing, Arnold, Steven E., Sapiro, Guillermo, Gupta, Anoopum S.

“…Eye movement assessments have the potential to help in diagnosis and tracking of neurological disorders. Cerebellar ataxias cause profound and characteristic…”
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Sensitive Quantification of Cerebellar Speech Abnormalities Using Deep Learning Models by Vattis, Kyriakos, Oubre, Brandon, Luddy, Anna C., Ouillon, Jessey S., Eklund, Nicole M., Stephen, Christopher D., Schmahmann, Jeremy D., Nunes, Adonay S., Gupta, Anoopum S.

“…Objective, sensitive, and meaningful disease assessments are critical to support clinical trials and clinical care. Speech changes are one of the earliest and…”
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Digital Phenotyping in Clinical Neurology by Gupta, Anoopum S

“…Internet-connected devices, including personal computers, smartphones, smartwatches, and voice assistants, have evolved into powerful multisensor technologies…”
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A pilot protocol to assess the feasibility of a virtual multiple crossover, randomized controlled trial design using methylphenidate in mild cognitive impairment by DesRuisseaux, Libby A, Williams, Victoria J, McManus, Alison J, Gupta, Anoopum S, Carlyle, Becky C, Azami, Hamed, Gerber, Jessica A, Bolling, Anna M, Cook, Carolyn L, Betensky, Rebecca A, Arnold, Steven E

“…The conventional clinical trial design in Alzheimer's disease (AD) and AD-related disorders (ADRDs) is the parallel-group randomized controlled trial. However,…”
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Estimation of ataxia severity in children with ataxia-telangiectasia using ankle-worn sensors by Lee, Juhyeon, Oubre, Brandon, Daneault, Jean-Francois, Lee, Sunghoon Ivan, Gupta, Anoopum S.

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Hepatic Encephalopathy is Associated With Slow Speech on Objective Assessment by Bloom, Patricia P., Robin, Jessica, Xu, Mengdan, Arvind, Ashwini, Daidone, Michael, Gupta, Anoopum S., Chung, Raymond T.

“…There are no available low-burden, point-of-care tests to diagnose, grade, and predict hepatic encephalopathy (HE). We evaluated speech as a biomarker of HE in…”
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Hippocampal Replay Is Not a Simple Function of Experience by Gupta, Anoopum S., van der Meer, Matthijs A.A., Touretzky, David S., Redish, A. David

“…Replay of behavioral sequences in the hippocampus during sharp wave ripple complexes (SWRs) provides a potential mechanism for memory consolidation and the…”
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Computer mouse use captures ataxia and parkinsonism, enabling accurate measurement and detection by Gajos, Krzysztof Z., Reinecke, Katharina, Donovan, Mary, Stephen, Christopher D., Hung, Albert Y., Schmahmann, Jeremy D., Gupta, Anoopum S.

“…Background Objective assessments of movement impairment are needed to support clinical trials and facilitate diagnosis. The objective of the current study was…”
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Analysis of Gait Sub-Movements to Estimate Ataxia Severity Using Ankle Inertial Data by Lee, Juhyeon, Oubre, Brandon, Daneault, Jean-Francois, Stephen, Christopher D., Schmahmann, Jeremy D., Gupta, Anoopum S., Lee, Sunghoon Ivan

“…Objective: Assessment of motor severity in cerebellar ataxia is critical for monitoring disease progression and evaluating the effectiveness of therapeutic…”
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Real-life Wrist Movement Patterns Capture Motor Impairment in Individuals with Ataxia-Telangiectasia by Gupta, Anoopum S., Luddy, Anna C., Khan, Nergis C., Reiling, Sara, Thornton, Jennifer Karlin

“…Sensitive motor outcome measures are needed to efficiently evaluate novel therapies for neurodegenerative diseases. Devices that can passively collect movement…”
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Accurate detection of cerebellar smooth pursuit eye movement abnormalities via mobile phone video and machine learning by Chang, Zhuoqing, Chen, Ziyu, Stephen, Christopher D., Schmahmann, Jeremy D., Wu, Hau-Tieng, Sapiro, Guillermo, Gupta, Anoopum S.

“…Eye movements are disrupted in many neurodegenerative diseases and are frequent and early features in conditions affecting the cerebellum. Characterizing eye…”
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Free-Living Motor Activity Monitoring in Ataxia-Telangiectasia by Khan, Nergis C., Pandey, Vineet, Gajos, Krzysztof Z., Gupta, Anoopum S.

“…With disease-modifying approaches under evaluation in ataxia-telangiectasia and other ataxias, there is a need for objective and reliable biomarkers of…”
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Decomposition of Reaching Movements Enables Detection and Measurement of Ataxia by Oubre, Brandon, Daneault, Jean-Francois, Whritenour, Kallie, Khan, Nergis C., Stephen, Christopher D., Schmahmann, Jeremy D., Lee, Sunghoon Ivan, Gupta, Anoopum S.

“…Technologies that enable frequent, objective, and precise measurement of ataxia severity would benefit clinical trials by lowering participation barriers and…”
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Differential speech and language characteristics across neurodegenerative disorders by Robin, Jessica, Xu, Mengdan, DeSouza, Danielle D, Gupta, Anoopum S, Kaufman, Liam D, Simpson, Bill

“…Background Speech and language changes have been reported to occur across a range of neurodegenerative disorders, including Alzheimer’s Disease (AD),…”
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