Search Results - "Guoxian Ding"

The mitochondrial function of peripheral blood mononuclear cells in frail older patients by Huang, Tingting, Qin, Li, Zhang, Danmei, Tong, Qiangwei, Zhu, Qianqian, Ding, Guoxian, Liu, Juan

“…Frailty increases the incidence of geriatric syndromes and even the risk of death in old adults. However, the diagnostic criteria for frailty are inconsistent…”
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Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice by Xie, Yu, Ding, Fei, Di, Wenjuan, Lv, Yifan, Xia, Fan, Sheng, Yunlu, Yu, Jing, Ding, Guoxian

“…A high‑fat diet (HFD) or obesity‑promoting diet is closely associated with metabolic diseases and intestinal tumors, particularly in middle‑aged individuals…”
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Differential Responses of White Adipose Tissue and Brown Adipose Tissue to Calorie Restriction During Aging by Sheng, Yunlu, Xia, Fan, Chen, Lei, Lv, Yifan, Lv, Shan, Yu, Jing, Liu, Juan, Ding, Guoxian

“…Abstract Age-related adipose tissue dysfunction is potentially important in the development of insulin resistance and metabolic disorder. Caloric restriction…”
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Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue by Kong, Xiaocen, Yu, Jing, Bi, Jianhua, Qi, Hanmei, Di, Wenjuan, Wu, Lin, Wang, Long, Zha, Juanmin, Lv, Shan, Zhang, Feng, Li, Yan, Hu, Fang, Liu, Feng, Zhou, Hong, Liu, Juan, Ding, Guoxian

“…Long-term glucocorticoid (GC) treatment induces central fat accumulation and metabolic dysfunction. We demonstrate that microRNA-27b (miR-27b) plays a central…”
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2,3’,4,4’,5-Pentachlorobiphenyl induced thyroid dysfunction by increasing mitochondrial oxidative stress by Xu, Wenli, Zhu, Xiaoxia, Wang, Li, Ding, Guoxian, Wang, Xiaodong, Sheng, Yunlu, Lv, Shan, Yu, Jing, Liu, Juan, Duan, Yu

“…Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) and are associated with thyroid diseases. Our previous study reported that…”
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Mechanism of thyroid hormone signaling in skeletal muscle of aging mice by Wang, Li, Sheng, Yunlu, Xu, Wenli, Sun, Minne, Lv, Shan, Yu, Jing, Wang, Xiaodong, Ding, Guoxian, Duan, Yu

“…Background and aim Skeletal muscle (SM) has been shown as a target of thyroid hormones (THs). However, the status of TH signaling in aged SM remains unclear…”
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2,3′,4,4′,5-Pentachlorobiphenyl Induced Thyrocyte Autophagy by Promoting Calcium Influx via Store-Operated Ca2+ Entry by Wang, Li, Xu, Wenli, Zhou, Qi, Xu, Bojin, Sheng, Yunlu, Sun, Minne, Chen, Huanhuan, Wang, Yucheng, Ding, Guoxian, Duan, Yu

“…Abstract PCB118, a 2,3′,4,4′,5-pentachlorobiphenyl, has been shown to destroy thyroidal ultrastructure and induce thyrocyte autophagy. Previously, we reported…”
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MiR-27b-3p Inhibition Enhances Browning of Epididymal Fat in High-Fat Diet Induced Obese Mice by Yu, Jing, Lv, Yifan, Wang, Fengliang, Kong, Xiaocen, Di, Wenjuan, Liu, Juan, Sheng, Yunlu, Lv, Shan, Ding, Guoxian

“…Long-term dysregulation of energy balance is the key component of the obesity epidemic. Given the harm of central obesity and the discovery that beige cells…”
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Molecular mechanisms of 2, 3', 4, 4', 5-pentachlorobiphenyl-induced thyroid dysfunction in FRTL-5 cells by Yang, Hui, Chen, Huanhuan, Guo, Hongwei, Li, Wen, Tang, Jinmei, Xu, Bojin, Sun, Minne, Ding, Guoxian, Jiang, Lin, Cui, Dai, Zheng, Xuqin, Duan, Yu

“…Polychlorinated biphenyls (PCBs) can severely interfere with multiple animals and human systems. To explore the molecular mechanisms underlying 2, 3', 4, 4',…”
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Application of Muscle Thickness and Quality Measured by Ultrasound in Frailty Assessment in China by Lv, Shan, Ling, Ling, Shi, Hui, Chen, Xing, Chen, Shu, Zhu, Siping, Lin, Wei, Lv, Rong, Ding, Guoxian

“…To explore the correlation between Fried Frailty Phenotype (FFP) and the muscle thickness and quality of local muscle, and to provide a reasonable basis for…”
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Distinct Serum and Fecal Metabolite Profiles Linking With Gut Microbiome in Older Adults With Frailty by Guo, Yan, Zhu, Guoqin, Wang, Fengliang, Zhang, Haoyu, Chen, Xin, Mao, Yan, Lv, Yifan, Xia, Fan, Jin, Yi, Ding, Guoxian, Yu, Jing

“…Frailty is a critical aging-related syndrome but the underlying metabolic mechanism remains poorly understood. The aim of this study was to identify novel…”
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Caloric restriction delays age-related muscle atrophy by inhibiting 11β-HSD1 to promote the differentiation of muscle stem cells by Lv, Shan, Shen, Qianjin, Li, Hengzhen, Chen, Qun, Xie, Wenqing, Li, Yusheng, Wang, Xiaodong, Ding, Guoxian

“…Calorie restriction (CR) is an important direction for the delay of sarcopenia in elderly individuals. However, the specific mechanisms of CR against aging are…”
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BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice by Wang, Long, Liu, Juan, Zhang, Aisen, Cheng, Peng, Zhang, Xiao, Lv, Shan, Wu, Lin, Yu, Jing, Di, Wenjuan, Zha, Juanmin, Kong, Xiaocen, Qi, Hanmei, Zhong, Yi, Ding, Guoxian

“…Inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is being pursued as a new therapeutic approach for the treatment of obesity and metabolic…”
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Identification of Sucrose Non-Fermenting―Related Kinase (SNRK) as a Suppressor of Adipocyte Inflammation by YUJIE LI, YAOHUI NIE, HELOU, Ynes, GUOXIAN DING, BIN FENG, GANG XU, SALOMON, Arthur, HAIYAN XU

“…In this study, the role of sucrose non-fermenting-related kinase (SNRK) in white adipocyte biology was investigated. SNRK is abundantly expressed in adipose…”
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Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway by Guo, Hongwei, Yang, Hui, Chen, Huanhuan, Li, Wen, Tang, Jinmei, Cheng, Pei, Xie, Yuchun, Liu, Yun, Ding, Guoxian, Cui, Dai, Zheng, Xuqin, Duan, Yu

“…ABSTRACT Polychlorinated biphenyls (PCBs) are typical persistent organic pollutants that can interfere with multiple organ systems of humans. Previously, we…”
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Association of Mild Cognitive Impairment and Muscle Mass/Strength in Community-Dwelling Older Chinese by Jing Yu, Tingting Bi, Yunlu Sheng, Shu Chen, Aisen Zhang, Hanmei Qi, Guoxian Ding, Rong Lv, Bin Lai

“…Background: This study elucidated the association between mild cognitive impairment (MCI) and muscle mass/strength in community-dwelling older Chinese…”
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The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus, and PTH by Liu, Jingning, Lv, Fangqiao, Sun, Wen, Tao, Chunxiang, Ding, Guoxian, Karaplis, Andrew, Brown, Edward, Goltzman, David, Miao, Dengshun

“…Patients with neonatal severe hyperparathyroidism (NSHPT) are homozygous for the calcium-sensing receptor (CaR) mutation and have very high circulating PTH,…”
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Comparison of Gene Transcription between Subcutaneous and Visceral Adipose Tissue in Chinese Adults by ZHA, Juan Min, DI, Wen Juan, ZHU, Ting, XIE, Yu, Yu, Jing, LIU, Juan, CHEN, Peng, DING, Guoxian

“…Obese individuals with fat stored in visceral adipose tissue (VAT) generally suffer greater adverse metabolic consequences than those with fat stored…”
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11β-hydroxysteroid dehydrogenase type 1 selective inhibitor BVT.2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction by Wu, Lin, Qi, Hanmei, Zhong, Yi, Lv, Shan, Yu, Jing, Liu, Juan, Wang, Long, Bi, Jianhua, Kong, Xiaocen, Di, Wenjuan, Zha, Juanmin, Liu, Feng, Ding, Guoxian

“…Pharmacologic glucocorticoids (GCs) inhibit osteoblast function and induce osteoporosis. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) may play a role in…”
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MEK/ERKs signaling is essential for lithium-induced neurite outgrowth in N2a cells by Wang, Zhuyao, Wang, Juan, Li, Jingjin, Wang, Xiaohui, Yao, Yuzhen, Zhang, Xiaojin, Li, Chuanfu, Cheng, Yunlin, Ding, Guoxian, Liu, Li, Ding, Zhengnian

“…► Lithium promotes neurite outgrowth. ► Lithium activates the MEK/ERKs signaling pathway and the PI3K/Akt signaling pathway. ► Inactivation of MEK/ERK…”
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