Search Results - "Guo, Zongyou"

Site-specific genome editing for correction of induced pluripotent stem cells derived from dominant dystrophic epidermolysis bullosa by Shinkuma, Satoru, Guo, Zongyou, Christiano, Angela M.

“…Genome editing with engineered site-specific endonucleases involves nonhomologous end-joining, leading to reading frame disruption. The approach is applicable…”
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Tissue engineering of human hair follicles using a biomimetic developmental approach by Abaci, Hasan Erbil, Coffman, Abigail, Doucet, Yanne, Chen, James, Jacków, Joanna, Wang, Etienne, Guo, Zongyou, Shin, Jung U., Jahoda, Colin A., Christiano, Angela M.

“…Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug…”
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Pumpless microfluidic platform for drug testing on human skin equivalents by Abaci, Hasan Erbil, Gledhill, Karl, Guo, Zongyou, Christiano, Angela M, Shuler, Michael L

“…Advances in bio-mimetic in vitro human skin models increase the efficiency of drug screening studies. In this study, we designed and developed a microfluidic…”
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CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells by Jacków, Joanna, Guo, Zongyou, Hansen, Corey, Abaci, Hasan E., Doucet, Yanne S., Shin, Jung U, Hayashi, Ryota, DeLorenzo, Dominick, Kabata, Yudai, Shinkuma, Satoru, Salas-Alanis, Julio C., Christiano, Angela M.

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disorder caused by mutations in the COL7A1 gene encoding type VII collagen (C7)…”
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A multi-organ chip with matured tissue niches linked by vascular flow by Ronaldson-Bouchard, Kacey, Teles, Diogo, Yeager, Keith, Tavakol, Daniel Naveed, Zhao, Yimu, Chramiec, Alan, Tagore, Somnath, Summers, Max, Stylianos, Sophia, Tamargo, Manuel, Lee, Busub Marcus, Halligan, Susan P., Abaci, Erbil Hasan, Guo, Zongyou, Jacków, Joanna, Pappalardo, Alberto, Shih, Jerry, Soni, Rajesh K., Sonar, Shivam, German, Carrie, Christiano, Angela M., Califano, Andrea, Hirschi, Karen K., Chen, Christopher S., Przekwas, Andrzej, Vunjak-Novakovic, Gordana

“…Engineered tissues can be used to model human pathophysiology and test the efficacy and safety of drugs. Yet, to model whole-body physiology and systemic…”
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Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs) by Itoh, Munenari, Umegaki-Arao, Noriko, Guo, Zongyou, Liu, Liang, Higgins, Claire A, Christiano, Angela M

“…Recent generation of patient-specific induced pluripotent stem cells (PS-iPSCs) provides significant advantages for cell- and gene-based therapy. Establishment…”
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Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells by Gledhill, Karl, Guo, Zongyou, Umegaki-Arao, Noriko, Higgins, Claire A, Itoh, Munenari, Christiano, Angela M

“…The current utility of 3D skin equivalents is limited by the fact that existing models fail to recapitulate the cellular complexity of human skin. They often…”
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Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing by Shin, Jung U, Abaci, Hasan E., Herron, Lauren, Guo, Zongyou, Sallee, Brigitte, Pappalardo, Alberto, Jackow, Joanna, Wang, Eddy Hsi Chun, Doucet, Yanne, Christiano, Angela M.

“…Drug screening studies for inflammatory skin diseases are currently performed using model systems that only partially recapitulate human diseased skin. Here,…”
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Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa by Umegaki-Arao, Noriko, Pasmooij, Anna M G, Itoh, Munenari, Cerise, Jane E, Guo, Zongyou, Levy, Brynn, Gostyński, Antoni, Rothman, Lisa R, Jonkman, Marcel F, Christiano, Angela M

“…Revertant mosaicism is a naturally occurring phenomenon involving spontaneous correction of a pathogenic gene mutation in a somatic cell. It has been observed…”
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A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa by Neumayer, Gernot, Torkelson, Jessica L., Li, Shengdi, McCarthy, Kelly, Zhen, Hanson H., Vangipuram, Madhuri, Mader, Marius M., Gebeyehu, Gulilat, Jaouni, Taysir M., Jacków-Malinowska, Joanna, Rami, Avina, Hansen, Corey, Guo, Zongyou, Gaddam, Sadhana, Tate, Keri M., Pappalardo, Alberto, Li, Lingjie, Chow, Grace M., Roy, Kevin R., Nguyen, Thuylinh Michelle, Tanabe, Koji, McGrath, Patrick S., Cramer, Amber, Bruckner, Anna, Bilousova, Ganna, Roop, Dennis, Tang, Jean Y., Christiano, Angela, Steinmetz, Lars M., Wernig, Marius, Oro, Anthony E.

“…We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable platform producing autologous organotypic iPS cell-derived induced skin composite…”
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Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells by Lv, Lei, Zhang, Tianwei, Yi, Qiyi, Huang, Yun, Wang, Zheng, Hou, Heli, Zhang, Huan, Zheng, Wei, Hao, Qiaomei, Guo, Zongyou, Cooke, Howard J., Shi, Qinghua

“…Most ovarian cancers originate from the ovarian surface epithelium and are characterized by aneuploid karyotypes. Aneuploidy, a consequence of chromosome…”
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Engineering human skin model innervated with itch sensory neuron‐like cells differentiated from induced pluripotent stem cells by Guo, Zongyou, Tong, Chi‐Kun, Jacków, Joanna, Doucet, Yanne S., Abaci, Hasan E., Zeng, Wangyong, Hansen, Corey, Hayashi, Ryota, DeLorenzo, Dominick, Rami, Avina, Pappalardo, Alberto, Lumpkin, Ellen A., Christiano, Angela M.

“…Atopic dermatitis (AD), driven by interleukins (IL‐4/IL‐13), is a chronic inflammatory skin disease characterized by intensive pruritus. However, it is unclear…”
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Building a microphysiological skin model from induced pluripotent stem cells by Guo, Zongyou, Higgins, Claire A, Gillette, Brian M, Itoh, Munenari, Umegaki, Noriko, Gledhill, Karl, Sia, Samuel K, Christiano, Angela M

“…The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs…”
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Next generation human skin constructs as advanced tools for drug development by Abaci, HE, Guo, Zongyou, Doucet, Yanne, Jacków, Joanna, Christiano, Angela

“…Many diseases, as well as side effects of drugs, manifest themselves through skin symptoms. Skin is a complex tissue that hosts various specialized cell types…”
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A Keratinocyte Hypermotility/Growth-Arrest Response Involving Laminin 5 and p16INK4A Activated in Wound Healing and Senescence by Natarajan, Easwar, Omobono, John D., II, Guo, Zongyou, Hopkinson, Susan, Lazar, Alexander J.F, Brenn, Thomas, Jones, Jonathan C, Rheinwald, James G

“…Keratinocytes become migratory to heal wounds, during early neoplastic invasion, and when undergoing telomere-unrelated senescence in culture. All three…”
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Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC-Derived Endothelial Cells by Abaci, Hasan E., Guo, Zongyou, Coffman, Abigail, Gillette, Brian, Lee, Wen-han, Sia, Samuel K., Christiano, Angela M.

“…Vascularization of engineered human skin constructs is crucial for recapitulation of systemic drug delivery and for their long‐term survival, functionality,…”
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Targeting the Jak/Signal Transducer and Activator of Transcription 3 Pathway with Ruxolitinib in a Mouse Model of Recessive Dystrophic Epidermolysis Bullosa–Squamous Cell Carcinoma by Jacków, Joanna, Rami, Avina, Hayashi, Ryota, Hansen, Corey, Guo, Zongyou, DeLorenzo, Dominick, Pappalardo, Alberto, Alvarez Cespedes, David, Kim, Arianna L., Perez-Lorenzo, Rolando, Owens, David M., Christiano, Angela M.

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A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status by Rheinwald, James G., Hahn, William C., Ramsey, Matthew R., Wu, Jenny Y., Guo, Zongyou, Tsao, Hensin, De Luca, Michele, Catricalà, Caterina, O'Toole, Kathleen M.

“…AUTHOR'S CORRECTION ( vol. 22 , p. 6930 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Fragile histidine triad gene expression in primary prostate cancer and in an in vitro model by Guo, Zongyou, Johansson, Sonny L., Rhim, Johng S., Vishwanatha, Jamboor K.

“…BACKGROUND The fragile histidine triad (FHIT) is frequently deleted and altered in many human cancers. Replacement of the FHIT gene into cancer cell lines…”
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Challenges and promises in modeling dermatologic disorders with bioengineered skin by Eungdamrong, Narat J, Higgins, Claire, Guo, Zongyou, Lee, Wen-Han, Gillette, Brian, Sia, Samuel, Christiano, Angela M

“…The tremendous cost of drug development is often attributed to the long time interval between identifying lead compounds in preclinical studies to assessing…”
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