Search Results - "Guo, Yusong R"

Structure-based membrane dome mechanism for Piezo mechanosensitivity by Guo, Yusong R, MacKinnon, Roderick

“…Mechanosensitive ion channels convert external mechanical stimuli into electrochemical signals for critical processes including touch sensation, balance, and…”
Get full text

Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation by Meyerson, Nicholas R., Zhou, Ligang, Guo, Yusong R., Zhao, Chen, Tao, Yizhi J., Krug, Robert M., Sawyer, Sara L.

“…TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the antiviral interferon response. The NS1 protein from all strains of influenza A virus binds…”
Get full text

Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus by Collier, Aaron M, Lyytinen, Outi L, Guo, Yusong R, Toh, Yukimatsu, Poranen, Minna M, Tao, Yizhi J

“…During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome…”
Get full text

Crystal structure of a nematode-infecting virus by Guo, Yusong R., Hryc, Corey F., Jakana, Joanita, Jiang, Hongbing, Wang, David, Chiu, Wah, Zhong, Weiwei, Tao, Yizhi J.

“…Orsay, the first virus discovered to naturally infect Caenorhabditis elegans or any nematode, has a bipartite, positive-sense RNA genome. Sequence analyses…”
Get full text

Force-induced conformational changes in PIEZO1 by Lin, Yi-Chih, Guo, Yusong R., Miyagi, Atsushi, Levring, Jesper, MacKinnon, Roderick, Scheuring, Simon

“…PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals. Partial molecular structures show that PIEZO1 is a bowl-shaped trimer…”
Get full text

Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications by Li, Sha, Li, Nan, He, Jie, Zhou, Runxin, Lu, Zhimin, Tao, Yizhi Jane, Guo, Yusong R, Wang, Yugang

“…Emerging discoveries about undocumented acyltransferase activities of known histone acetyltransferases (HATs) advance our understandings in the regulation of…”
Get full text

Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells by Fan, Yanlin, Guo, Yusong R, Yuan, Wang, Zhou, Ying, Holt, Matthew V, Wang, Tao, Demeler, Borries, Young, Nicolas L, Zhong, Weiwei, Tao, Yizhi J

“…Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until six years ago…”
Get full text

TMEM16F Expressed in Kupffer Cells Regulates Liver Inflammation and Metabolism to Protect Against Listeria Monocytogenes by Tang, Jianlong, Song, Hua, Li, Shimin, Lam, Sin Man, Ping, Jieming, Yang, Mengyun, Li, Na, Chang, Teding, Yu, Ze, Liu, Weixiang, Lu, Yan, Zhu, Min, Tang, Zhaohui, Liu, Zheng, Guo, Yusong R., Shui, Guanghou, Veillette, André, Zeng, Zhutian, Wu, Ning

“…Infection by bacteria leads to tissue damage and inflammation, which need to be tightly controlled by host mechanisms to avoid deleterious consequences. It is…”
Get full text

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase by Wang, Yugang, Guo, Yusong R., Liu, Ke, Yin, Zheng, Liu, Rui, Xia, Yan, Tan, Lin, Yang, Peiying, Lee, Jong-Ho, Li, Xin-jian, Hawke, David, Zheng, Yanhua, Qian, Xu, Lyu, Jianxin, He, Jie, Xing, Dongming, Tao, Yizhi Jane, Lu, Zhimin

“…The histone acetyl transferase KAT2A (also known as GCN5) can also catalyse histone succinylation, with the α-KGDH complex providing a local source of…”
Get full text

Coordination of RAB-8 and RAB-11 during unconventional protein secretion by Li, Xinxin, Liu, Bowen, Wen, Yue, Wang, Jiabin, Guo, Yusong R, Shi, Anbing, Lin, Long

“…Multiple physiology-pertinent transmembrane proteins reach the cell surface via the Golgi-bypassing unconventional protein secretion (UcPS) pathway. By…”
Get full text

Elastic properties and shape of the Piezo dome underlying its mechanosensory function by Haselwandter, Christoph A., Guo, Yusong R., Fu, Ziao, MacKinnon, Roderick

“…We show in the companion paper that the free membrane shape of lipid bilayer vesicles containing the mechanosensitive ion channel Piezo can be predicted, with…”
Get full text

Quantitative prediction and measurement of Piezo's membrane footprint by Haselwandter, Christoph A., Guo, Yusong R., Fu, Ziao, MacKinnon, Roderick

“…Piezo proteins are mechanosensitive ion channels that can locally curve the membrane into a dome shape [Y. R. Guo, R. MacKinnon, eLife 6, e33660 (2017)]. The…”
Get full text

Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription by Yu, Weixing, Zhou, Runxin, Li, Nan, Lei, Zhi-Chao, Guo, Dingyuan, Peng, Fei, Li, Yan, Bai, Xue, Feng, Shan, Wang, Yu, He, Jie, Yin, Sibi, Zeng, Xiao, He, Leya, Gao, Yuan, Li, Mingchang, Guo, Yusong R., Liu, Ke, Wang, Yugang

“…Tyrosine sulfation is a common posttranslational modification in mammals. To date, it has been thought to be limited to secreted and transmembrane proteins,…”
Get full text

Author Correction: Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription by Yu, Weixing, Zhou, Runxin, Li, Nan, Lei, Zhi-Chao, Guo, Dingyuan, Peng, Fei, Li, Yan, Bai, Xue, Feng, Shan, Wang, Yu, He, Jie, Yin, Sibi, Zeng, Xiao, He, Leya, Gao, Yuan, Li, Mingchang, Guo, Yusong R., Liu, Ke, Wang, Yugang

Get full text

Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation by Wang, Yugang, Guo, Yusong R., Xing, Dongming, Tao, Yizhi Jane, Lu, Zhimin

Get full text

Orsay Virus CP-δ Adopts a Novel β-Bracelet Structural Fold and Incorporates into Virions as a Head Fiber by Guo, Yusong R, Fan, Yanlin, Zhou, Ying, Jin, Miao, Zhang, Jim L, Jiang, Hongbing, Holt, Matthew V, Wang, Tao, Young, Nicolas L, Wang, David, Zhong, Weiwei, Tao, Yizhi J

“…Fiber proteins are commonly found in eukaryotic and prokaryotic viruses, where they play important roles in mediating viral attachment and host cell entry…”
Get full text

Biological functions and therapeutic potential of acylation by histone acetyltransferases by Li, Nan, Hamor, Clark, An, Yahang, Zhu, Licheng, Gong, Yusheng, Toh, Yukimatsu, Guo, Yusong R.

“…Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional…”
Get full text

Structural Response of the Piezo Channel to Force Application at Different Frequencies by Lin, Yi-Chih, Guo, Yusong R., Miyagi, Atsushi, MacKinnon, Roderick, Scheuring, Simon

Get full text

Structural Response of the Piezo Channel Upon Application of Force by Lin, Yi-Chih, Guo, Yusong R., Miyagi, Atsushi, Levring, Jesper, MacKinnon, Roderick, Scheuring, Simon

Get full text

KAT2A coupled with the -KGDH complex acts as a histone H3 succinyltransferase by Wang, Yugang, Guo, Yusong R, Liu, Ke, Yin, Zheng, Liu, Rui, Xia, Yan, Tan, Lin, Yang, Peiying, Lee, Jong-Ho, Li, Xin-jian, Hawke, David, Zheng, Yanhua, Qian, Xu, Lyu, Jianxin, He, Jie, Xing, Dongming, Tao, Yizhi Jane, Lu, Zhimin

Get full text